PMID- 37126671
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231109
IS  - 1092-874X (Electronic)
IS  - 1091-5818 (Print)
IS  - 1091-5818 (Linking)
VI  - 42
IP  - 5
DP  - 2023 Sep-Oct
TI  - Alterations of Systemic and Hepatic Metabolic Function Following Exposure to 
      Trans-nonachlor in Low and High Fat Diet Fed Male Sprague Dawley Rats.
PG  - 407-419
LID - 10.1177/10915818231170527 [doi]
AB  - The overall prevalence of metabolic diseases such as type 2 diabetes (T2D) and 
      associated co-morbidities have increased at an alarming rate in the United States 
      and worldwide. There is a growing body of epidemiological evidence implicating 
      exposure to persistent organic pollutants (POPs), including legacy organochlorine 
      (OC) pesticides and their bioaccumulative metabolites, in the pathogenesis of 
      metabolic diseases. Therefore, the goal of the present study was to determine if 
      exposure to trans-nonachlor, a bioaccumulative OC pesticide contaminant, in 
      concert with high fat diet intake induced metabolic dysfunction. Briefly, male 
      Sprague Dawley rats were exposed to trans-nonachlor (.5 or 5 ppm) in either a low 
      fat (LFD) or high fat diet (HFD) for 16 weeks. At 8 weeks of intake, 
      trans-nonachlor decreased serum triglyceride levels in LFD and HFD fed animals 
      and at 16 weeks compared to LFD fed animals. Interestingly, serum glucose levels 
      were decreased by trans-nonachlor (5 ppm) in LFD fed animals at 16 weeks. Serum 
      free fatty acids were increased by trans-nonachlor exposure (5 ppm) in LFD fed 
      animals at 16 weeks. HFD fed animals displayed signs of hepatic steatosis 
      including elevated liver triglycerides, liver enzymes, and liver lipid 
      peroxidation which were not significantly altered by trans-nonachlor exposure. 
      However, there was a trans-nonachlor mediated increase in expression of fatty 
      acid synthase in livers of LFD fed animals and not HFD fed animals. Thus, the 
      present data indicate exposure to trans-nonachlor in conjunction with LFD or HFD 
      intake produces both diet and exposure dependent effects on lipid and glucose 
      metabolism.
FAU - McDevitt, Erin
AU  - McDevitt E
AD  - Mississippi State University College of Veterinary Medicine, Center for 
      Environmental Health Sciences, Department of Comparative Biomedical Sciences, 
      Mississippi State University, MS, USA.
AD  - University of Mississippi Medical Center, School of Medicine, Jackson, MS, USA.
FAU - Henein, Lucie
AU  - Henein L
AD  - Mississippi State University College of Veterinary Medicine, Center for 
      Environmental Health Sciences, Department of Comparative Biomedical Sciences, 
      Mississippi State University, MS, USA.
FAU - Crawford, Anna
AU  - Crawford A
AUID- ORCID: 0000-0002-2838-729X
AD  - Mississippi State University College of Veterinary Medicine, Center for 
      Environmental Health Sciences, Department of Comparative Biomedical Sciences, 
      Mississippi State University, MS, USA.
FAU - Kondakala, Sandeep
AU  - Kondakala S
AD  - Mississippi State University College of Veterinary Medicine, Center for 
      Environmental Health Sciences, Department of Comparative Biomedical Sciences, 
      Mississippi State University, MS, USA.
FAU - Young, Darian
AU  - Young D
AD  - Mississippi State University College of Veterinary Medicine, Center for 
      Environmental Health Sciences, Department of Comparative Biomedical Sciences, 
      Mississippi State University, MS, USA.
FAU - Meek, Edward
AU  - Meek E
AD  - Mississippi State University College of Veterinary Medicine, Center for 
      Environmental Health Sciences, Department of Comparative Biomedical Sciences, 
      Mississippi State University, MS, USA.
FAU - Howell, George E 3rd
AU  - Howell GE 3rd
AUID- ORCID: 0000-0001-8761-976X
AD  - Mississippi State University College of Veterinary Medicine, Center for 
      Environmental Health Sciences, Department of Comparative Biomedical Sciences, 
      Mississippi State University, MS, USA.
LA  - eng
GR  - P20 GM103646/GM/NIGMS NIH HHS/United States
GR  - R15 ES026791/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20230426
PL  - United States
TA  - Int J Toxicol
JT  - International journal of toxicology
JID - 9708436
RN  - 3734-49-4 (nonachlor)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Male
MH  - Rats, Sprague-Dawley
MH  - Diet, High-Fat/adverse effects
MH  - *Diabetes Mellitus, Type 2/metabolism/pathology
MH  - *Hydrocarbons, Chlorinated/metabolism/pharmacology
MH  - Liver
MH  - *Pesticides/toxicity
PMC - PMC10530595
MID - NIHMS1888961
OTO - NOTNLM
OT  - diabetes
OT  - hepatic steatosis
OT  - high fat diet
OT  - persistent organic pollutant
OT  - trans-nonachlor
COIS- Declaration of Conflicting Interests The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2023/05/01 18:42
MHDA- 2023/05/01 18:43
PMCR- 2023/09/27
CRDT- 2023/05/01 15:23
PHST- 2023/05/01 18:43 [medline]
PHST- 2023/05/01 18:42 [pubmed]
PHST- 2023/05/01 15:23 [entrez]
PHST- 2023/09/27 00:00 [pmc-release]
AID - 10.1177/10915818231170527 [doi]
PST - ppublish
SO  - Int J Toxicol. 2023 Sep-Oct;42(5):407-419. doi: 10.1177/10915818231170527. Epub 
      2023 Apr 26.