PMID- 37127178
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230731
IS  - 1535-7732 (Electronic)
IS  - 1051-0443 (Linking)
VI  - 34
IP  - 8
DP  - 2023 Aug
TI  - The Effect of Endovascular Treatment of Renal Artery Stenoses on Coexistent 
      Aneurysms Associated with Fibromuscular Dysplasia.
PG  - 1353-1358
LID - S1051-0443(23)00326-3 [pii]
LID - 10.1016/j.jvir.2023.04.019 [doi]
AB  - PURPOSE: Endovascular data on patients with coexistent renal artery stenosis 
      (RAS) and renal artery aneurysm (RAA) caused by fibromuscular dysplasia (FMD) are 
      scarce, and the outcomes from RAS-specific treatment on RAA remain unclear. This 
      study aimed to evaluate the safety and effectiveness of RAS-specific endovascular 
      management in patients with coexisting RAA caused by FMD. MATERIALS AND METHODS: 
      Clinical and endovascular data on 19 patients with coexistent RAS and RAA caused 
      by FMD who underwent RAS-specific endovascular therapy were analyzed 
      prospectively. An RAA located within 10 mm of the RAS was defined as a 
      stenosis-related RAA (SRAA), and long-term outcomes were evaluated. RESULTS: 
      Nineteen patients (24 RASs and 30 RAAs) underwent endovascular therapy. 
      Twenty-one RASs were treated with balloon angioplasty alone, whereas 3 RASs were 
      treated with stent implantation. None of the RAAs were treated directly. During 
      an average of 4.2 years +/- 3.2 of follow-up, systolic and diastolic blood 
      pressures decreased from 183.0 mm Hg +/- 19.5 and 120.2 mm Hg +/- 19.0 to 127.9 mm Hg 
      +/- 10.3 and 80.9 mm Hg +/- 6.9, respectively; the number of antihypertensive 
      medications reduced from 1.7 +/- 1.0 to 0.8 +/- 0.3 (for all, P < .001). The serum 
      creatinine level remained stable. The maximum diameter of all RAAs decreased from 
      14.6 mm +/- 9.7 to 11.3 mm +/- 8.4 (P < .001). There was a significant difference in 
      the improvement rate of the maximum diameter between SRAAs (65.0%, 13 of 20) and 
      non-SRAAs (20.0%, 2 of 10) (P = .019). CONCLUSIONS: RAS-specific endovascular 
      therapy is safe and effective and possibly aids in preventing RAA progression in 
      patients with FMD with coexistent RAS and RAA.
CI  - Copyright (c) 2023 SIR. Published by Elsevier Inc. All rights reserved.
FAU - Chen, Yang
AU  - Chen Y
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular 
      Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China.
FAU - Dong, Hui
AU  - Dong H
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular 
      Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China.
FAU - Zou, Yubao
AU  - Zou Y
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular 
      Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China.
FAU - Li, Hongwu
AU  - Li H
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular 
      Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China.
FAU - Che, Wuqiang
AU  - Che W
AD  - Department of Cardiology, China-Japan Friendship Hospital, Beijing, China.
FAU - Xiong, Hongliang
AU  - Xiong H
AD  - Department of Cardiology, the Second Affiliated Hospital of Nanchang University, 
      Jiangxi, China.
FAU - Jiang, Xiongjing
AU  - Jiang X
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular 
      Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China. Electronic address: jiangxiongjing@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230429
PL  - United States
TA  - J Vasc Interv Radiol
JT  - Journal of vascular and interventional radiology : JVIR
JID - 9203369
SB  - IM
MH  - Humans
MH  - *Renal Artery Obstruction/diagnostic imaging/etiology/therapy
MH  - Treatment Outcome
MH  - *Fibromuscular Dysplasia/complications/diagnostic imaging/therapy
MH  - Renal Artery/surgery
MH  - *Aneurysm/diagnostic imaging/etiology/therapy
MH  - Retrospective Studies
EDAT- 2023/05/02 00:42
MHDA- 2023/07/31 06:42
CRDT- 2023/05/01 19:24
PHST- 2022/08/30 00:00 [received]
PHST- 2023/03/21 00:00 [revised]
PHST- 2023/04/23 00:00 [accepted]
PHST- 2023/07/31 06:42 [medline]
PHST- 2023/05/02 00:42 [pubmed]
PHST- 2023/05/01 19:24 [entrez]
AID - S1051-0443(23)00326-3 [pii]
AID - 10.1016/j.jvir.2023.04.019 [doi]
PST - ppublish
SO  - J Vasc Interv Radiol. 2023 Aug;34(8):1353-1358. doi: 10.1016/j.jvir.2023.04.019. 
      Epub 2023 Apr 29.