PMID- 37127791
OWN - NLM
STAT- MEDLINE
DCOM- 20230503
LR  - 20230510
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 May 1
TI  - The interplay between bicarbonate kinetics and gastrointestinal upset on 
      ergogenic potential after sodium bicarbonate intake: a randomized double-blind 
      placebo-controlled trial.
PG  - 7081
LID - 10.1038/s41598-023-34343-0 [doi]
LID - 7081
AB  - This double-blind placebo-controlled cross-over study utilized comprehensive 
      monitoring of blood bicarbonate (HCO(3)( )) kinetics and evaluation of 
      gastrointestinal (GI) upset to determine their impact on an ergogenic potential 
      of sodium bicarbonate (SB) co-ingested with carbohydrate (CHO). Nineteen CrossFit 
      athletes performed 6 bouts of 15 s Wingate Anaerobic Test (WAnT) 90 min 
      post-ingestion of 0.4 g.kg(-1) body mass (BM) of SB (SB + CHO treatment) or PLA 
      (PLA + CHO treatment) with 15 g CHO. Blood HCO(3)( ) concentration was evaluated 
      at baseline, 30-, 60-, 75- and 90 min post-ingestion, in between WAnT bouts, and 
      3 and 45 min post-exercise, while GI upset at 120 min after protocol started. 
      Control (no supplementation; CTRL) procedures were also performed. An effective 
      elevation of extra-cellular buffering capacity was observed 60-90 min 
      post-ingestion of SB + CHO. At mean peak blood HCO(3)( ), or at start of exercise 
      an increase > 6 mmol.L(-1) in HCO(3)( ) was noted in 84% and 52.6% participants, 
      respectively. SB + CHO did not prevent performance decrements in WAnT bouts. 
      There were no significant relationships between changes in blood HCO(3)( ) and 
      WAnTs' performance. Total GI was significantly higher in SB + CHO compared to 
      CTRL, and stomach problems in SB + CHO compared to CTRL and PLA + CHO. There were 
      inverse associations between peak- (p = 0.031; r = - 0.495), average- (p = 0.002; 
      r = - 0.674) and minimum power (p = 0.008; r = - 0.585) and total GI upset, as 
      well as average power and severe GI distress (p = 0.042; r = - 0.471) at 
      SB + CHO. The implemented dose of SB + CHO was effective in improving buffering 
      capacity, but did not prevent decrements in WAnTs' performance. GI side effects 
      were crucial in affecting the ergogenic potential of SB and thus must be 
      insightfully monitored in future studies.
CI  - (c) 2023. The Author(s).
FAU - Durkalec-Michalski, Krzysztof
AU  - Durkalec-Michalski K
AD  - Department of Sports Dietetics, Poznan University of Physical Education, 61-871, 
      Poznan, Poland. durkalec-michalski@awf.poznan.pl.
AD  - Sport Sciences-Biomedical Department, Faculty of Physical Education and Sport, 
      Charles University, Prague, Czech Republic. durkalec-michalski@awf.poznan.pl.
FAU - Nowaczyk, Paulina M
AU  - Nowaczyk PM
AD  - Department of Sports Dietetics, Poznan University of Physical Education, 61-871, 
      Poznan, Poland.
FAU - Kaminska, Joanna
AU  - Kaminska J
AD  - Department of Physiology and Biochemistry, Poznan University of Physical 
      Education, Poznan, Poland.
FAU - Saunders, Bryan
AU  - Saunders B
AD  - Applied Physiology and Nutrition Research Group, School of Physical Education and 
      Sport, Rheumatology Division, Faculdade de Medicina FMUSP, University of Sao 
      Paulo, Sao Paulo, Brazil.
AD  - Institute of Orthopedics and Traumatology, Faculty of Medicine FMUSP, University 
      of Sao Paulo, Sao Paulo, Brazil.
FAU - Loniewski, Igor
AU  - Loniewski I
AD  - Department of Biochemical Sciences, Pomeranian Medical University in Szczecin, 
      Szczecin, Poland.
FAU - Czubaszek, Dominika
AU  - Czubaszek D
AD  - Department of Sports Dietetics, Poznan University of Physical Education, 61-871, 
      Poznan, Poland.
FAU - Steffl, Michal
AU  - Steffl M
AD  - Sport Sciences-Biomedical Department, Faculty of Physical Education and Sport, 
      Charles University, Prague, Czech Republic.
FAU - Podgorski, Tomasz
AU  - Podgorski T
AD  - Department of Physiology and Biochemistry, Poznan University of Physical 
      Education, Poznan, Poland.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20230501
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 8MDF5V39QO (Sodium Bicarbonate)
RN  - 0 (Bicarbonates)
RN  - 0 (Polyesters)
SB  - IM
MH  - Humans
MH  - Sodium Bicarbonate/adverse effects
MH  - Bicarbonates
MH  - Cross-Over Studies
MH  - *Gastrointestinal Diseases/chemically induced
MH  - Polyesters
MH  - Double-Blind Method
MH  - *Athletic Performance
PMC - PMC10151363
COIS- I.L. is a shareholder of an alkali products distributor and has received 
      honoraria from the Sanum Polska sp. z o. o. However, the content of this study 
      was not constrained by this fact in absolutely no extend. K.D.-M., P.M.N., J.K., 
      B.S., D.C., M.S., and T.P. report no conflicts of interest. The results of the 
      present study do not constitute endorsement by the Scientific Reports. The 
      authors declare that the results of the study are presented clearly, honestly, 
      and without fabrication, falsification, or inappropriate data manipulation.
EDAT- 2023/05/02 00:42
MHDA- 2023/05/03 06:42
PMCR- 2023/05/01
CRDT- 2023/05/01 23:26
PHST- 2023/02/04 00:00 [received]
PHST- 2023/04/27 00:00 [accepted]
PHST- 2023/05/03 06:42 [medline]
PHST- 2023/05/02 00:42 [pubmed]
PHST- 2023/05/01 23:26 [entrez]
PHST- 2023/05/01 00:00 [pmc-release]
AID - 10.1038/s41598-023-34343-0 [pii]
AID - 34343 [pii]
AID - 10.1038/s41598-023-34343-0 [doi]
PST - epublish
SO  - Sci Rep. 2023 May 1;13(1):7081. doi: 10.1038/s41598-023-34343-0.