PMID- 37128738
OWN - NLM
STAT- MEDLINE
DCOM- 20230503
LR  - 20230505
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 33
IP  - 9
DP  - 2023 Apr 25
TI  - Dysregulated dynamic time-varying triple-network segregation in children with 
      autism spectrum disorder.
PG  - 5717-5726
LID - 10.1093/cercor/bhac454 [doi]
AB  - One of the remarkable characteristics of autism spectrum disorder (ASD) is the 
      dysregulation of functional connectivity of the triple-network, which includes 
      the salience network (SN), default mode network (DMN), and central executive 
      network (CEN). However, there is little known about the segregation of the 
      triple-network dynamics in ASD. This study used resting-state functional magnetic 
      resonance imaging data including 105 ASD and 102 demographically-matched typical 
      developing control (TC) children. We compared the dynamic time-varying 
      triple-network segregation and triple-network functional connectivity states 
      between ASD and TC groups, and examined the relationship between dynamic 
      triple-network segregation alterations and clinical symptoms of ASD. The average 
      dynamic network segregation value of the DMN with SN and the DMN with CEN in ASD 
      was lower but the coefficient of variation (CV) of dynamic network segregation of 
      the DMN with CEN was higher in ASD. Furthermore, partially reduced triple-network 
      segregation associated with the DMN was found in connectivity states analysis of 
      ASD. These abnormal average values and CV of dynamic network segregation 
      predicted social communication deficits and restricted and repetitive behaviors 
      in ASD. Our findings indicate abnormal dynamic time-varying triple-network 
      segregation of ASD and highlight the crucial role of the triple-network in the 
      neural mechanisms underlying ASD.
CI  - (c) The Author(s) 2022. Published by Oxford University Press. All rights reserved. 
      For permissions, please e-mail: journals.permissions@oup.com.
FAU - Guo, Xiaonan
AU  - Guo X
AD  - Department of Electronics and Communication Engineering, School of Information 
      Science and Engineering, Yanshan University, No. 438 West Hebei Avenue, 
      Qinhuangdao, 066004, China.
AD  - Hebei Key Laboratory of Information Transmission and Signal Processing, Yanshan 
      University, No. 438 West Hebei Avenue, Qinhuangdao, 066004, China.
FAU - Cao, Yabo
AU  - Cao Y
AD  - Department of Electronics and Communication Engineering, School of Information 
      Science and Engineering, Yanshan University, No. 438 West Hebei Avenue, 
      Qinhuangdao, 066004, China.
AD  - Hebei Key Laboratory of Information Transmission and Signal Processing, Yanshan 
      University, No. 438 West Hebei Avenue, Qinhuangdao, 066004, China.
FAU - Liu, Junfeng
AU  - Liu J
AD  - Department of Neurology, West China Hospital, Sichuan University, China. No. 37 
      Guo Xue Xiang, Chengdu, 610041, China.
FAU - Zhang, Xia
AU  - Zhang X
AD  - Department of Electronics and Communication Engineering, School of Information 
      Science and Engineering, Yanshan University, No. 438 West Hebei Avenue, 
      Qinhuangdao, 066004, China.
AD  - Hebei Key Laboratory of Information Transmission and Signal Processing, Yanshan 
      University, No. 438 West Hebei Avenue, Qinhuangdao, 066004, China.
FAU - Zhai, Guangjin
AU  - Zhai G
AD  - Department of Electronics and Communication Engineering, School of Information 
      Science and Engineering, Yanshan University, No. 438 West Hebei Avenue, 
      Qinhuangdao, 066004, China.
AD  - Hebei Key Laboratory of Information Transmission and Signal Processing, Yanshan 
      University, No. 438 West Hebei Avenue, Qinhuangdao, 066004, China.
FAU - Chen, Heng
AU  - Chen H
AUID- ORCID: 0000-0001-6939-7665
AD  - Department of Medical Information Engineering, School of Medicine, Guizhou 
      University, Jiaxiu Road, Guiyang, 550025, China.
FAU - Gao, Le
AU  - Gao L
AD  - Department of Electronics and Communication Engineering, School of Information 
      Science and Engineering, Yanshan University, No. 438 West Hebei Avenue, 
      Qinhuangdao, 066004, China.
AD  - Hebei Key Laboratory of Information Transmission and Signal Processing, Yanshan 
      University, No. 438 West Hebei Avenue, Qinhuangdao, 066004, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Humans
MH  - Child
MH  - *Brain
MH  - *Autism Spectrum Disorder
MH  - Magnetic Resonance Imaging/methods
MH  - Neural Pathways
MH  - Communication
MH  - Brain Mapping/methods
OTO - NOTNLM
OT  - autism spectrum disorder
OT  - dynamic network segregation
OT  - functional magnetic resonance imaging
OT  - triple-network
EDAT- 2023/05/02 06:41
MHDA- 2023/05/03 06:42
CRDT- 2023/05/02 03:13
PHST- 2022/09/06 00:00 [received]
PHST- 2022/10/19 00:00 [revised]
PHST- 2022/10/21 00:00 [accepted]
PHST- 2023/05/03 06:42 [medline]
PHST- 2023/05/02 06:41 [pubmed]
PHST- 2023/05/02 03:13 [entrez]
AID - 6832151 [pii]
AID - 10.1093/cercor/bhac454 [doi]
PST - ppublish
SO  - Cereb Cortex. 2023 Apr 25;33(9):5717-5726. doi: 10.1093/cercor/bhac454.