PMID- 37129709
OWN - NLM
STAT- MEDLINE
DCOM- 20230523
LR  - 20230523
IS  - 1720-8319 (Electronic)
IS  - 1594-0667 (Linking)
VI  - 35
IP  - 6
DP  - 2023 Jun
TI  - Frailty and caregiver relationship quality in older patients diagnosed with 
      transthyretin cardiac amyloidosis.
PG  - 1363-1367
LID - 10.1007/s40520-023-02419-6 [doi]
AB  - Aim of the study was to explore frailty and quality of the relationship with the 
      caregiver in a cohort of older patients with transthyretin cardiac amyloidosis 
      (ATTR-CA). Sixty-eight consecutive ATTR-CA patients were recruited and assessed 
      for frailty, depressive symptoms, quality of the relationship in terms of social 
      support, or conflict toward caregivers, New York Heart Association Class (NYHA), 
      and National Amyloid Center score (NAC Score) for grading disease severity. 
      Results showed that 10% of patients were frail. Depressive symptoms were present 
      in 46% of patients. Regression analyses showed that both mFI and depression were 
      associated with worse perception of social support, and that mFI and NAC score 
      were associated with higher levels of conflict perceived in the caregivers' 
      relationship. Overall, the mFI score was associated with worse perceived social 
      support and caregiver relationship quality. Tertiary care heart failure clinics 
      should actively support the patient-caregiver relationship to improve quality of 
      life.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
FAU - Fumagalli, Carlo
AU  - Fumagalli C
AUID- ORCID: 0000-0001-7963-5049
AD  - Department of Advanced Medical and Surgical Sciences, University of Campania 
      "Luigi Vanvitelli", Naples, Italy.
AD  - Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy.
FAU - Smorti, Martina
AU  - Smorti M
AUID- ORCID: 0000-0002-5867-9859
AD  - Department of Surgical, Medical and Molecular Pathology and Critical Care 
      Medicine, University of Pisa, Pisa, Italy.
FAU - Ponti, Lucia
AU  - Ponti L
AUID- ORCID: 0000-0001-8255-5672
AD  - Department of Humanities, University of Urbino, 61029, Urbino, Italy. 
      lucia.ponti@uniurb.it.
AD  - Tuscan Regional Amyloidosis Centre, Careggi University Hospital, Florence, Italy. 
      lucia.ponti@uniurb.it.
FAU - Pozza, Francesca
AU  - Pozza F
AD  - Department of Surgical, Medical and Molecular Pathology and Critical Care 
      Medicine, University of Pisa, Pisa, Italy.
FAU - Argiro, Alessia
AU  - Argiro A
AUID- ORCID: 0000-0002-6394-9948
AD  - Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy.
AD  - Tuscan Regional Amyloidosis Centre, Careggi University Hospital, Florence, Italy.
FAU - Credi, Giacomo
AU  - Credi G
AD  - Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy.
FAU - Di Mario, Carlo
AU  - Di Mario C
AUID- ORCID: 0000-0002-4461-2055
AD  - Division of Interventional Structural Cardiology, Cardiothoracovascular 
      Department, Careggi University Hospital, Florence, Italy.
FAU - Marfella, Raffaele
AU  - Marfella R
AUID- ORCID: 0000-0003-3960-9270
AD  - Department of Advanced Medical and Surgical Sciences, University of Campania 
      "Luigi Vanvitelli", Naples, Italy.
FAU - Marchionni, Niccolo
AU  - Marchionni N
AUID- ORCID: 0000-0002-8101-4695
AD  - Department of Experimental and Clinical Medicine, University of Florence, 
      Florence, Italy.
FAU - Olivotto, Iacopo
AU  - Olivotto I
AUID- ORCID: 0000-0003-1751-9266
AD  - Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy.
AD  - Meyer Children Hospital, Florence, Italy.
FAU - Perfetto, Federico
AU  - Perfetto F
AUID- ORCID: 0000-0003-0276-8331
AD  - Tuscan Regional Amyloidosis Centre, Careggi University Hospital, Florence, Italy.
AD  - IV Internal Medicine Division, Careggi University Hospital, Florence, Italy.
FAU - Ungar, Andrea
AU  - Ungar A
AUID- ORCID: 0000-0002-8965-4523
AD  - Geriatric Intensive Care Unit, University of Florence, Florence, Italy.
FAU - Cappelli, Francesco
AU  - Cappelli F
AUID- ORCID: 0000-0002-1622-0732
AD  - Tuscan Regional Amyloidosis Centre, Careggi University Hospital, Florence, Italy.
AD  - Division of Interventional Structural Cardiology, Cardiothoracovascular 
      Department, Careggi University Hospital, Florence, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230502
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
RN  - 0 (Prealbumin)
SB  - IM
MH  - Humans
MH  - Aged
MH  - Caregivers
MH  - Prealbumin
MH  - Quality of Life
MH  - *Frailty/complications
MH  - *Amyloidosis/complications
MH  - *Cardiomyopathies/complications
OTO - NOTNLM
OT  - ATTR-CA
OT  - Caregiver
OT  - Depression
OT  - Frailty
OT  - Quality of relationship
EDAT- 2023/05/02 12:43
MHDA- 2023/05/23 06:42
CRDT- 2023/05/02 11:08
PHST- 2023/03/30 00:00 [received]
PHST- 2023/04/18 00:00 [accepted]
PHST- 2023/05/23 06:42 [medline]
PHST- 2023/05/02 12:43 [pubmed]
PHST- 2023/05/02 11:08 [entrez]
AID - 10.1007/s40520-023-02419-6 [pii]
AID - 10.1007/s40520-023-02419-6 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2023 Jun;35(6):1363-1367. doi: 10.1007/s40520-023-02419-6. 
      Epub 2023 May 2.