PMID- 37131017
OWN - NLM
STAT- MEDLINE
DCOM- 20230602
LR  - 20230602
IS  - 1573-6628 (Electronic)
IS  - 1092-7875 (Linking)
VI  - 27
IP  - 7
DP  - 2023 Jul
TI  - Association of Maternal Asthma and Total Serum Immunoglobulin E levels with 
      Obstetric Complications: The Japan Environment and Children's Study.
PG  - 1229-1237
LID - 10.1007/s10995-023-03647-y [doi]
AB  - OBJECTIVE: To evaluate the association between maternal asthma (MA) and obstetric 
      complications, while considering subdivided total serum immunoglobulin E (IgE) 
      levels. METHODS: Data of the participants enrolled in the Japan Environment and 
      Children's Study between 2011 and 2014 were analyzed. In total, 77,131 women with 
      singleton live births at and after 22 weeks of gestation were included. MA was 
      defined based on a self-administered questionnaire. Women with MA were stratified 
      based on the quartile of total serum IgE levels during pregnancy as follows: low 
      IgE levels (< 52.40 IU/mL), moderate IgE levels (52.40-331.00 IU/mL), and high 
      IgE levels (> 331.00 IU/mL). The adjusted odds ratios (aORs) for preterm births 
      (PTB), small for gestational age (SGA) infants, gestational diabetes mellitus, 
      and hypertensive disorders of pregnancy (HDP) were calculated using multivariable 
      logistic regression, while considering women without MA as reference and maternal 
      socioeconomic factors as confounders. RESULTS: The aORs for SGA infants and HDP 
      in women with MA and high total serum IgE levels were 1.26 (95% confidence 
      interval [CI], 1.05-1.50) and 1.33 (95% CI, 1.06-1.66), respectively. The aOR for 
      SGA infants among women with MA and moderate total serum IgE levels was 0.85 (95% 
      CI, 0.73-0.99). The aOR for PTB among women with MA and low total serum IgE 
      levels was 1.26 (95% CI, 1.04-1.52). CONCLUSIONS FOR PRACTICE: MA with subdivided 
      total serum IgE levels was associated with obstetric complications. Total serum 
      IgE level may be a potential prognostic marker to predict obstetric complications 
      in pregnancies with MA.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Murata, Tsuyoshi
AU  - Murata T
AUID- ORCID: 0000-0001-9506-117X
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan. tuyoshim@fmu.ac.jp.
AD  - Department of Obstetrics and Gynecology, Fukushima Medical University School of 
      Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. tuyoshim@fmu.ac.jp.
FAU - Kyozuka, Hyo
AU  - Kyozuka H
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
AD  - Department of Obstetrics and Gynecology, Fukushima Medical University School of 
      Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Fukuda, Toma
AU  - Fukuda T
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
AD  - Department of Obstetrics and Gynecology, Fukushima Medical University School of 
      Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Yasuda, Shun
AU  - Yasuda S
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
AD  - Department of Obstetrics and Gynecology, Fukushima Medical University School of 
      Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Yamaguchi, Akiko
AU  - Yamaguchi A
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
AD  - Department of Obstetrics and Gynecology, Fukushima Medical University School of 
      Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Sato, Akiko
AU  - Sato A
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Ogata, Yuka
AU  - Ogata Y
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Shinoki, Kosei
AU  - Shinoki K
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Hosoya, Mitsuaki
AU  - Hosoya M
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
AD  - Department of Pediatrics, Fukushima Medical University School of Medicine, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Yasumura, Seiji
AU  - Yasumura S
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
AD  - Department of Public Health, Fukushima Medical University School of Medicine, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Hashimoto, Koichi
AU  - Hashimoto K
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
AD  - Department of Pediatrics, Fukushima Medical University School of Medicine, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Nishigori, Hidekazu
AU  - Nishigori H
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
AD  - Fukushima Medical Center for Children and Women, Fukushima Medical University, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
FAU - Fujimori, Keiya
AU  - Fujimori K
AD  - Fukushima Regional Center for the Japan Environment and Children's Study, 1 
      Hikarigaoka, Fukushima, 960-1295, Japan.
AD  - Department of Obstetrics and Gynecology, Fukushima Medical University School of 
      Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
CN  - and the Japan Environment and Children's Study (JECS) Group
LA  - eng
PT  - Journal Article
DEP - 20230502
PL  - United States
TA  - Matern Child Health J
JT  - Maternal and child health journal
JID - 9715672
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Pregnancy
MH  - Infant, Newborn
MH  - Infant
MH  - Female
MH  - Child
MH  - Humans
MH  - Japan/epidemiology
MH  - *Premature Birth/epidemiology/etiology
MH  - Infant, Small for Gestational Age
MH  - *Diabetes, Gestational/epidemiology
MH  - *Pre-Eclampsia
MH  - Immunoglobulin E
OAB - What is Already Known on this Subject? Maternal asthma (MA) is associated with 
      several obstetric complications, including preterm births (PTB), small for 
      gestational age (SGA) infants, and hypertensive disorders of pregnancy (HDP). Few 
      studies with data from nationwide cohorts have elucidated the association between 
      MA and obstetric complications comprehensively while accounting for the 
      subdivided objective biomarkers of MA.What this Study Adds? MA with subdivided 
      total serum IgE levels was associated with various obstetric complications. Total 
      serum IgE level may be a potential prognostic marker for pregnant women with MA 
      to predict the potential risk of PTB, SGA infants, and HDP.
OABL- eng
OTO - NOTNLM
OT  - Asthma
OT  - Gestational diabetes mellitus
OT  - Hypertensive disorders of pregnancy
OT  - Immunoglobulin E
OT  - Preterm birth
OT  - Small for gestational age infant
EDAT- 2023/05/03 00:41
MHDA- 2023/06/02 06:43
CRDT- 2023/05/02 23:24
PHST- 2023/03/16 00:00 [accepted]
PHST- 2023/06/02 06:43 [medline]
PHST- 2023/05/03 00:41 [pubmed]
PHST- 2023/05/02 23:24 [entrez]
AID - 10.1007/s10995-023-03647-y [pii]
AID - 10.1007/s10995-023-03647-y [doi]
PST - ppublish
SO  - Matern Child Health J. 2023 Jul;27(7):1229-1237. doi: 10.1007/s10995-023-03647-y. 
      Epub 2023 May 2.