PMID- 37131751
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231023
DP  - 2023 Apr 18
TI  - An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity.
LID - 2023.04.14.536934 [pii]
LID - 10.1101/2023.04.14.536934 [doi]
AB  - Aged skin is prone to viral infections, but the mechanisms responsible for this 
      immunosenescent immune risk are unclear. We observed that aged murine and human 
      skin expressed reduced antiviral proteins (AVPs) and circadian regulators 
      including Bmal1 and Clock. Bmal1 and Clock were found to control rhythmic AVP 
      expression in skin and such circadian-control of AVPs was diminished by 
      disruption of immune cell interleukin 27 signaling and deletion of Bmal1/Clock 
      genes in mouse skins, as well as siRNA-mediated knockdown of CLOCK in human 
      primary keratinocytes. We found that treatment of circadian enhancing agents, 
      nobiletin and SR8278, reduced infection of herpes simplex virus 1 (HSV1) in 
      epidermal explants and human keratinocytes in a Bmal1/Clock-dependent manner. 
      Circadian enhancing treatment also reversed susceptibility of aging murine skin 
      and human primary keratinocytes to viral infection. These findings reveal an 
      evolutionarily conserved and age-sensitive circadian regulation of cutaneous 
      antiviral immunity, underscoring circadian restoration as an antiviral strategy 
      in aging populations.
FAU - Kirchner, Stephen
AU  - Kirchner S
AUID- ORCID: 0000-0002-8045-5747
FAU - Lei, Vivian
AU  - Lei V
FAU - Kim, Paul
AU  - Kim P
FAU - Patel, Meera
AU  - Patel M
FAU - Shannon, Jessica
AU  - Shannon J
FAU - Corcoran, David
AU  - Corcoran D
FAU - Hughes, Dalton
AU  - Hughes D
FAU - Waters, Diana
AU  - Waters D
FAU - Dzirasa, Kafui
AU  - Dzirasa K
AUID- ORCID: 0000-0003-4280-9994
FAU - Erdmann, Detlev
AU  - Erdmann D
FAU - Coers, Jorn
AU  - Coers J
FAU - MacLeod, Amanda
AU  - MacLeod A
FAU - Zhang, Jennifer Y
AU  - Zhang JY
LA  - eng
PT  - Preprint
DEP - 20230418
PL  - United States
TA  - bioRxiv
JT  - bioRxiv : the preprint server for biology
JID - 101680187
UIN - JCI Insight. 2023 Sep 19;:. PMID: 37725438
PMC - PMC10153172
EDAT- 2023/05/03 06:42
MHDA- 2023/05/03 06:43
PMCR- 2023/05/02
CRDT- 2023/05/03 01:59
PHST- 2023/05/03 06:43 [medline]
PHST- 2023/05/03 06:42 [pubmed]
PHST- 2023/05/03 01:59 [entrez]
PHST- 2023/05/02 00:00 [pmc-release]
AID - 2023.04.14.536934 [pii]
AID - 10.1101/2023.04.14.536934 [doi]
PST - epublish
SO  - bioRxiv [Preprint]. 2023 Apr 18:2023.04.14.536934. doi: 
      10.1101/2023.04.14.536934.