PMID- 37132073
OWN - NLM
STAT- MEDLINE
DCOM- 20230516
LR  - 20230525
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Linking)
VI  - 77
IP  - 4
DP  - 2023 Jul
TI  - Neonatal olfactory bulbectomy induces anxiety-related behavior and modifies 
      dopaminergic receptor expression in post-pubertal rats.
PG  - e22272
LID - 10.1002/syn.22272 [doi]
AB  - Olfaction is a complex physiological process producing effects in the central 
      nervous system (CNS) and implicated in emotional processes. Indeed, the olfactory 
      bulbs (OB) send projections to various CNS regions including the nucleus 
      accumbens (NAcc) and caudate-putamen (CPu). Both the NAcc and CPu receive 
      important dopaminergic input. Emerging evidence suggests that dopamine (DA) is 
      related to anxiety-related behaviors. Therefore, we aimed to investigate the 
      consequences of neonatal olfactory bulbectomy (nOBX) to anxiety-related behavior 
      as assayed in the elevated plus maze (EPM) as well as the expression of 
      dopaminergic receptors (D1-like, D2-like, and D3) in the NAcc and CPu at pre- and 
      post-pubertal ages in the rat. The results show that nOBX increased the number of 
      entries in the open arm of the EPM post-pubertally, suggesting an 
      anxiolytic-related effect. nOBX increased the D2-like binding in the NAcc shell 
      and D3 binding in the NAcc core pre-pubertally. At post-pubertal ages, the D3 
      binding was reduced at the olfactory tubercle and islands of Calleja in nOBX 
      rats. Alterations in the DA receptor expression may be one mechanism responsible 
      for the observed behavioral modifications in nOBX rats.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Flores, Gonzalo
AU  - Flores G
AUID- ORCID: 0000-0002-4100-2104
AD  - Lab. Neuropsiquiatria, Instituto de Fisiologia, Benemerita Universidad Autonoma 
      de Puebla, Puebla, Mexico.
FAU - Gomez-Villalobos, Maria de Jesus
AU  - Gomez-Villalobos MJ
AD  - Lab. Fisiologia Cardiovascular, Instituto de Fisiologia, Benemerita Universidad 
      Autonoma de Puebla, Puebla, Mexico.
FAU - Iannitti, Tommaso
AU  - Iannitti T
AD  - Department of Medical Sciences, Section of Experimental Medicine, University of 
      Ferrara, Ferrara, Italy.
FAU - Morales-Medina, Julio Cesar
AU  - Morales-Medina JC
AUID- ORCID: 0000-0002-8712-2400
AD  - Centro de Investigacion en Reproduccion Animal, CINVESTAV-Universidad Autonoma de 
      Tlaxcala, Tlaxcala, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230502
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - VTD58H1Z2X (Dopamine)
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Receptors, Dopamine D1)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Dopamine/metabolism
MH  - Smell
MH  - Receptors, Dopamine/metabolism
MH  - Nucleus Accumbens
MH  - Anxiety
MH  - *Anti-Anxiety Agents/pharmacology
MH  - Receptors, Dopamine D1/metabolism
OTO - NOTNLM
OT  - anxiety
OT  - dopamine
OT  - elevated plus maze
OT  - islands of Calleja
OT  - neonatal bulbectomy
OT  - nucleus accumbens
EDAT- 2023/05/03 06:42
MHDA- 2023/05/16 06:42
CRDT- 2023/05/03 02:25
PHST- 2023/04/14 00:00 [revised]
PHST- 2022/11/11 00:00 [received]
PHST- 2023/04/16 00:00 [accepted]
PHST- 2023/05/16 06:42 [medline]
PHST- 2023/05/03 06:42 [pubmed]
PHST- 2023/05/03 02:25 [entrez]
AID - 10.1002/syn.22272 [doi]
PST - ppublish
SO  - Synapse. 2023 Jul;77(4):e22272. doi: 10.1002/syn.22272. Epub 2023 May 2.