PMID- 37133268
OWN - NLM
STAT- MEDLINE
DCOM- 20230713
LR  - 20230718
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 64
IP  - 7
DP  - 2023 Jul
TI  - Twenty-four hour pattern of childhood febrile seizures substantiated by time 
      series meta-analysis: Circadian medicine perspectives.
PG  - 1739-1749
LID - 10.1111/epi.17639 [doi]
AB  - Major objectives of this work were to: (1) substantiate the 24-hour pattern in 
      the occurrence of childhood febrile seizures (CFSs) by a novel time series 
      meta-analysis of past reported time-of-day data and (2) discuss its potential 
      circadian rhythm-dependencies. Comprehensive search of the published literature 
      retrieved eight articles that met inclusion criteria. Three investigations were 
      conducted in Iran, two in Japan, and one each in Finland, Italy, and South Korea, 
      representing a total of 2461 mostly simple febrile seizures of children who were 
      on average about 2 years of age. Population-mean cosinor analysis validated 
      (p < .001) a 24-hour pattern in the onset of CFSs, with an approximate four-fold 
      difference in the proportion of children expressing seizures at its peak at 
      18:04 h (95% confidence interval: 16:40-19:07 h) vs trough at 06:00 h, in the 
      absence of meaningful time-of-day differences in mean body temeprarure. The CFS 
      time-of-day pattern likely derives from the actions of multiple circadian 
      rhythms, particularly the cytokines that comprise the pyrogenic inflammatory 
      pathway and melatonin that influences the excitation level of central neurons and 
      helps regulate body temperature. Past laboratory animal and patient 
      investigations document that the vulnerability to a seizure by a provoking 
      trigger of the same intensity is not the same but different in a 
      predictable-in-time manner during the 24 h as a circadian 
      susceptibility/resistance rhythm. Knowledge of the marked disparity in the 
      time-of-day risk of CFSs can be translated into improved prevention, particularly 
      during the late afternoon and early evening when highest, through proper timing 
      of prophylactic interventions.
CI  - (c) 2023 International League Against Epilepsy.
FAU - Smolensky, Michael H
AU  - Smolensky MH
AUID- ORCID: 0000-0002-9184-0739
AD  - Department of Biomedical Engineering, Cockrell School of Engineering, The 
      University of Texas at Austin, Austin, Texas, USA.
FAU - Shah, Ami P
AU  - Shah AP
AUID- ORCID: 0000-0002-2836-6544
AD  - UMC Children's Hospital of Nevada, University of Nevada-Las Vegas Kirk Kerkorian 
      School of Medicine, Las Vegas, Nevada, USA.
FAU - Fernandez, Jose R
AU  - Fernandez JR
AUID- ORCID: 0000-0002-8652-0124
AD  - Bioengineering & Chronobiology Laboratories, Atlantic Research Center for 
      Telecommunication Technologies, University of Vigo, Vigo, Spain.
AD  - Bioengineering & Chronobiology Research Group, Galicia Sur Health Research 
      Institute (IIS Galicia Sur), Galician Health Service, Vigo, Spain.
FAU - Sackett-Lundeen, Linda
AU  - Sackett-Lundeen L
AUID- ORCID: 0000-0002-4267-0673
AD  - American Association for Medical Chronobiology & Chronotherapeutics, Roseville, 
      Minnesota, USA.
FAU - Hermida, Ramon C
AU  - Hermida RC
AUID- ORCID: 0000-0002-8853-5901
AD  - Department of Biomedical Engineering, Cockrell School of Engineering, The 
      University of Texas at Austin, Austin, Texas, USA.
AD  - Bioengineering & Chronobiology Laboratories, Atlantic Research Center for 
      Telecommunication Technologies, University of Vigo, Vigo, Spain.
AD  - Bioengineering & Chronobiology Research Group, Galicia Sur Health Research 
      Institute (IIS Galicia Sur), Galician Health Service, Vigo, Spain.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20230515
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
MH  - Humans
MH  - *Seizures, Febrile
MH  - Time Factors
MH  - Circadian Rhythm
MH  - Fever
MH  - Body Temperature
OTO - NOTNLM
OT  - children
OT  - circadian rhythm
OT  - disease resistance
OT  - disease susceptibility
OT  - febrile seizures
OT  - time series meta-analysis
EDAT- 2023/05/03 12:42
MHDA- 2023/07/13 06:42
CRDT- 2023/05/03 09:03
PHST- 2023/04/30 00:00 [revised]
PHST- 2023/02/16 00:00 [received]
PHST- 2023/05/01 00:00 [accepted]
PHST- 2023/07/13 06:42 [medline]
PHST- 2023/05/03 12:42 [pubmed]
PHST- 2023/05/03 09:03 [entrez]
AID - 10.1111/epi.17639 [doi]
PST - ppublish
SO  - Epilepsia. 2023 Jul;64(7):1739-1749. doi: 10.1111/epi.17639. Epub 2023 May 15.