PMID- 37137426
OWN - NLM
STAT- MEDLINE
DCOM- 20231128
LR  - 20231128
IS  - 1885-5857 (Electronic)
IS  - 1885-5857 (Linking)
VI  - 76
IP  - 12
DP  - 2023 Dec
TI  - Angina in patients with severe aortic stenosis undergoing transcatheter aortic 
      valve replacement.
PG  - 991-1002
LID - S1885-5857(23)00113-5 [pii]
LID - 10.1016/j.rec.2023.04.004 [doi]
AB  - INTRODUCTION AND OBJECTIVES: To evaluate the prevalence, clinical 
      characteristics, and outcomes of patients with angina undergoing transcatheter 
      aortic valve replacement (TAVR) for severe aortic stenosis. METHODS: A total of 
      1687 consecutive patients with severe aortic stenosis undergoing TAVR at our 
      center were included and classified according to patient-reported angina symptoms 
      prior to the TAVR procedure. Baseline, procedural and follow-up data were 
      collected in a dedicated database. RESULTS: A total of 497 patients (29%) had 
      angina prior to the TAVR procedure. Patients with angina at baseline showed a 
      worse New York Heart Association (NYHA) functional class (NYHA class> II: 69% vs 
      63%; P=.017), a higher rate of coronary artery disease (74% vs 56%; P <.001), and 
      a lower rate of complete revascularization (70% vs 79%; P <.001). Angina at 
      baseline had no impact on all-cause mortality (HR, 1.02; 95%CI, 0.71-1.48; 
      P=.898) and cardiovascular mortality (HR, 1.2; 95%CI, 0.69-2.11; P=.517) at 1 
      year. However, persistent angina at 30 days post-TAVR was associated with 
      increased all-cause mortality (HR, 4.86; 95%CI, 1.71-13.8; P=.003) and 
      cardiovascular mortality (HR, 20.7; 95%CI, 3.50-122.6; P=.001) at 1-year 
      follow-up. CONCLUSIONS: More than one-fourth of patients with severe aortic 
      stenosis undergoing TAVR had angina prior to the procedure. Angina at baseline 
      did not appear to be a sign of a more advanced valvular disease and had no 
      prognostic impact; however, persistent angina at 30 days post-TAVR was associated 
      with worse clinical outcomes.
CI  - Copyright (c) 2023 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, 
      S.L.U. All rights reserved.
FAU - Keller, Lukas S
AU  - Keller LS
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Nuche, Jorge
AU  - Nuche J
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Avvedimento, Marisa
AU  - Avvedimento M
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Real, Carlos
AU  - Real C
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Farjat-Pasos, Julio
AU  - Farjat-Pasos J
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Paradis, Jean-Michel
AU  - Paradis JM
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - DeLarochelliere, Robert
AU  - DeLarochelliere R
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Poulin, Anthony
AU  - Poulin A
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Kalavrouziotis, Dimitris
AU  - Kalavrouziotis D
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Dumont, Eric
AU  - Dumont E
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Galhardo, Attilio
AU  - Galhardo A
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Mengi, Siddhartha
AU  - Mengi S
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Mohammadi, Siamak
AU  - Mohammadi S
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
FAU - Rodes-Cabau, Josep
AU  - Rodes-Cabau J
AD  - Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada. 
      Electronic address: josep.rodes@criucpq.ulaval.ca.
LA  - eng
LA  - spa
PT  - Journal Article
DEP - 20230501
PL  - Spain
TA  - Rev Esp Cardiol (Engl Ed)
JT  - Revista espanola de cardiologia (English ed.)
JID - 101587954
SB  - IM
MH  - Humans
MH  - *Transcatheter Aortic Valve Replacement/methods
MH  - Treatment Outcome
MH  - *Aortic Valve Stenosis/complications/diagnosis/surgery
MH  - Risk Factors
MH  - Prognosis
MH  - Angina Pectoris/epidemiology/etiology/surgery
MH  - Aortic Valve/surgery
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Angina
OT  - Angina pectoris
OT  - Aortic valve stenosis
OT  - Coronary artery disease
OT  - Enfermedad coronaria
OT  - Estenosis aortica
OT  - Implante percutaneo de valvula aortica
OT  - Transcatheter aortic valve replacement
EDAT- 2023/05/04 00:42
MHDA- 2023/11/28 06:42
CRDT- 2023/05/03 19:18
PHST- 2023/01/15 00:00 [received]
PHST- 2023/04/03 00:00 [accepted]
PHST- 2023/11/28 06:42 [medline]
PHST- 2023/05/04 00:42 [pubmed]
PHST- 2023/05/03 19:18 [entrez]
AID - S1885-5857(23)00113-5 [pii]
AID - 10.1016/j.rec.2023.04.004 [doi]
PST - ppublish
SO  - Rev Esp Cardiol (Engl Ed). 2023 Dec;76(12):991-1002. doi: 
      10.1016/j.rec.2023.04.004. Epub 2023 May 1.