PMID- 37138465
OWN - NLM
STAT- MEDLINE
DCOM- 20230901
LR  - 20230901
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 64
IP  - 8
DP  - 2023 Aug
TI  - The impact of iodine contrast agent on radiation dose of heart and blood: a 
      comparison between coronary CT angiography and cardiac calcium scoring CT.
PG  - 2387-2392
LID - 10.1177/02841851231170850 [doi]
AB  - BACKGROUND: Iodine contrast agent (CA) is widely used in cardiac computed 
      tomography (CT). The CA can increase the organ radiation doses due to the 
      photoelectric effect. PURPOSE: To investigate the impact of CA on radiation dose 
      in cardiac CT by comparing the radiation dose between contrast coronary CT 
      angiography (CCTA) and non-contrast calcium scoring CT (CSCT). MATERIAL AND 
      METHODS: Radiation doses were computationally calculated for 30 individual 
      patients who received CSCT and CCTA in the same exam session. The geometry and 
      acquisition parameters were modeled in the simulations based on individual 
      patient CT images and acquisitions. Doses in the presence and absence of CA were 
      obtained in the aorta, left ventricle (LV), right ventricle (RV), and myocardial 
      tissue (MT). The dose values were normalized by size-specific dose estimate 
      (SSDE). The dose enhancement factors (DEF(SSDE)) were calculated as the ratio of 
      doses in CCTA over doses in CSCT. RESULTS: Compared to the CSCT scans, doses 
      increase in the CCTA scans in the aorta (DEF(SSDE) = 2.14 +/- 0.20), LV 
      (DEF(SSDE) = 1.78 +/- 0.26), and RV (DEF(SSDE) = 1.31 +/- 0.22). A linear relation is 
      observed between the local CA concentrations and the dose increase in the heart; 
      DEF(SSDE) = 0.07*I(mg/mL) + 0.80 (R(2) = 0.8; p < 0.01). The DEF(SSDE) in the MT 
      (DEF(SSDE) = 0.96 +/- 0.08) showed no noticeable impact of CA on the dose in this 
      tissue. In addition, patient variability in the dose distributions was observed. 
      CONCLUSION: A linear causal relation exists between local CA concentration and 
      increase in radiation dose in cardiac CT. For the same CT exposure, dose to the 
      heart is on average 55% higher in contrast cardiac CT.
FAU - Mazloumi, Mahta
AU  - Mazloumi M
AUID- ORCID: 0000-0002-1150-5050
AD  - Department of Radiology, Vrije Universiteit Brussel, Universitair Ziekenhuis 
      Brussel (UZ Brussel), Brussels, Belgium. RINGGOLD: 60201
FAU - Van Gompel, Gert
AU  - Van Gompel G
AD  - Department of Radiology, Vrije Universiteit Brussel, Universitair Ziekenhuis 
      Brussel (UZ Brussel), Brussels, Belgium. RINGGOLD: 60201
FAU - Tanaka, Kaoru
AU  - Tanaka K
AD  - Department of Radiology, Vrije Universiteit Brussel, Universitair Ziekenhuis 
      Brussel (UZ Brussel), Brussels, Belgium. RINGGOLD: 60201
FAU - Argacha, Jean-Francois
AU  - Argacha JF
AD  - Department of Cardiology, Vrije Universiteit Brussel, Universitair Ziekenhuis 
      Brussel (UZ Brussel), Brussels, Belgium. RINGGOLD: 70493
FAU - de Mey, Johan
AU  - de Mey J
AD  - Department of Radiology, Vrije Universiteit Brussel, Universitair Ziekenhuis 
      Brussel (UZ Brussel), Brussels, Belgium. RINGGOLD: 60201
FAU - Buls, Nico
AU  - Buls N
AD  - Department of Radiology, Vrije Universiteit Brussel, Universitair Ziekenhuis 
      Brussel (UZ Brussel), Brussels, Belgium. RINGGOLD: 60201
LA  - eng
PT  - Journal Article
DEP - 20230503
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
RN  - 0 (Contrast Media)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Humans
MH  - *Contrast Media
MH  - *Calcium
MH  - Computed Tomography Angiography/methods
MH  - Coronary Angiography/methods
MH  - Tomography, X-Ray Computed/methods
MH  - Radiation Dosage
OTO - NOTNLM
OT  - Intravenous contrast agents
OT  - cardiac
OT  - computed tomography
OT  - dosimetry
OT  - radiation safety
EDAT- 2023/05/04 06:41
MHDA- 2023/09/01 06:43
CRDT- 2023/05/04 01:13
PHST- 2023/09/01 06:43 [medline]
PHST- 2023/05/04 06:41 [pubmed]
PHST- 2023/05/04 01:13 [entrez]
AID - 10.1177/02841851231170850 [doi]
PST - ppublish
SO  - Acta Radiol. 2023 Aug;64(8):2387-2392. doi: 10.1177/02841851231170850. Epub 2023 
      May 3.