PMID- 37139662
OWN - NLM
STAT- MEDLINE
DCOM- 20231204
LR  - 20231217
IS  - 1365-2184 (Electronic)
IS  - 0960-7722 (Print)
IS  - 0960-7722 (Linking)
VI  - 56
IP  - 12
DP  - 2023 Dec
TI  - Preventing acute liver injury via hepatocyte-targeting nano-antioxidants.
PG  - e13494
LID - 10.1111/cpr.13494 [doi]
LID - e13494
AB  - Acute liver injury (ALI) is a severe liver disease that is characterized by 
      sudden and massive hepatocyte necrosis and deterioration of liver functions. 
      Oxidative stress is increasingly recognized as a key factor in the induction and 
      progression of ALI. Scavenging excessive reactive oxygen species (ROS) with 
      antioxidants has become a promising therapeutic option, but intrinsically 
      hepatocyte-targeting antioxidants with excellent bioavailability and 
      biocompatibility are yet to be developed. Herein, self-assembling nanoparticles 
      (NPs) composed of amphiphilic polymers are introduced to encapsulate organic 
      Selenium compound L-Se-methylselenocysteine (SeMC) and form SeMC NPs, which 
      protect the viabilities and functions of cultured hepatocytes in drug- or 
      chemical-induced acute hepatotoxicity models via efficient ROS removal. After 
      further functionalization with the hepatocyte-targeting ligand glycyrrhetinic 
      acid (GA), the resultant GA-SeMC NPs exhibit enhanced hepatocyte uptake and liver 
      accumulation. In mouse models of ALI induced by acetaminophen (APAP) or carbon 
      tetrachloride (CCl(4) ), treatment with GA-SeMC NPs significantly decrease the 
      levels of hepatic lipid peroxidation, tissue vacuolization and serum liver 
      transaminases, while prominently increase that of endogenous antioxidant enzymes. 
      Our study therefore presents a liver-targeting drug delivery strategy for the 
      prevention and treatment of hepatic diseases.
CI  - (c) 2023 The Authors. Cell Proliferation published by Beijing Institute for Stem 
      Cell and Regenerative Medicine and John Wiley & Sons Ltd.
FAU - Yuan, Xuejiao
AU  - Yuan X
AD  - College of Chemistry and Materials Science, The Education Ministry Key Lab of 
      Resource Chemistry, Joint International Research Laboratory of Resource Chemistry 
      of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional 
      Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, 
      Shanghai Normal University, Shanghai, China.
FAU - Zhou, Yanfeng
AU  - Zhou Y
AUID- ORCID: 0000-0001-5103-2879
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Sun, Jinli
AU  - Sun J
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Wang, Shanshan
AU  - Wang S
AD  - College of Chemistry and Materials Science, The Education Ministry Key Lab of 
      Resource Chemistry, Joint International Research Laboratory of Resource Chemistry 
      of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional 
      Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, 
      Shanghai Normal University, Shanghai, China.
FAU - Hu, Xingjie
AU  - Hu X
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Li, Jiyu
AU  - Li J
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
AD  - He'nan Xibaikang Health Industry Co., Ltd, Jiyuan, China.
FAU - Huang, Jing
AU  - Huang J
AD  - Department of Neurology, Xuhui District Central Hospital, Shanghai, China.
FAU - Chen, Nan
AU  - Chen N
AUID- ORCID: 0000-0001-8536-6631
AD  - College of Chemistry and Materials Science, The Education Ministry Key Lab of 
      Resource Chemistry, Joint International Research Laboratory of Resource Chemistry 
      of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional 
      Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, 
      Shanghai Normal University, Shanghai, China.
LA  - eng
GR  - 2019-01-07-00-01-E00059/Major Science and Technology Innovation Program of 
      Shanghai Municipal Education Commission/
GR  - 2021YFF0701800/National Key R&D Program of China/
GR  - 21974089/National Natural Science Foundation of China/
GR  - 21ZR1436600/Natural Science Foundation of Shanghai/
GR  - 20YF1422200/Shanghai Sailing Program/
PT  - Journal Article
DEP - 20230504
PL  - England
TA  - Cell Prolif
JT  - Cell proliferation
JID - 9105195
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
RN  - P540XA09DR (Glycyrrhetinic Acid)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Antioxidants/pharmacology/therapeutic use
MH  - Reactive Oxygen Species/metabolism
MH  - Liver/metabolism
MH  - Hepatocytes
MH  - Oxidative Stress
MH  - *Glycyrrhetinic Acid/metabolism
MH  - Mice, Inbred C57BL
PMC - PMC10693184
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/04 06:42
MHDA- 2023/12/04 12:41
PMCR- 2023/05/04
CRDT- 2023/05/04 03:44
PHST- 2023/04/18 00:00 [revised]
PHST- 2023/03/15 00:00 [received]
PHST- 2023/04/22 00:00 [accepted]
PHST- 2023/12/04 12:41 [medline]
PHST- 2023/05/04 06:42 [pubmed]
PHST- 2023/05/04 03:44 [entrez]
PHST- 2023/05/04 00:00 [pmc-release]
AID - CPR13494 [pii]
AID - 10.1111/cpr.13494 [doi]
PST - ppublish
SO  - Cell Prolif. 2023 Dec;56(12):e13494. doi: 10.1111/cpr.13494. Epub 2023 May 4.