PMID- 3713995
OWN - NLM
STAT- MEDLINE
DCOM- 19860715
LR  - 20190912
IS  - 0143-4179 (Print)
IS  - 0143-4179 (Linking)
VI  - 7
IP  - 3
DP  - 1986 Apr
TI  - Effect of oxytocin on acute enkephalin tolerance in mice.
PG  - 247-50
AB  - Intracerebroventricular (i.c.v.) administration of a test dose of 0.5 microgram 
      D-Met2-Pro5-enkephalinamide (ENK) resulted in analgesia. Acute tolerance 
      developed if a tolerance-inducing high dose of 5 micrograms ENK was administered 
      i.c.v. prior to the test dose. Tolerance appeared as a reduction of the analgesic 
      effect of the test dose. Subcutaneous (s.c.) injection of oxytocin (OXT) 
      inhibited the development of tolerance. It is suggested that OXT is able to 
      modify the development of tolerance to enkephalins, which are ligands of 
      delta-opiate rather than mu-opiate receptors.
FAU - Schwarzberg, H
AU  - Schwarzberg H
FAU - Kovacs, G L
AU  - Kovacs GL
FAU - Penke, B
AU  - Penke B
FAU - Telegdy, G
AU  - Telegdy G
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Analgesia
MH  - Animals
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Drug Tolerance
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Oxytocin/*pharmacology
EDAT- 1986/04/01 00:00
MHDA- 1986/04/01 00:01
CRDT- 1986/04/01 00:00
PHST- 1986/04/01 00:00 [pubmed]
PHST- 1986/04/01 00:01 [medline]
PHST- 1986/04/01 00:00 [entrez]
AID - 0143-4179(86)90018-1 [pii]
AID - 10.1016/0143-4179(86)90018-1 [doi]
PST - ppublish
SO  - Neuropeptides. 1986 Apr;7(3):247-50. doi: 10.1016/0143-4179(86)90018-1.