PMID- 37140041
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20240122
IS  - 1744-7593 (Electronic)
IS  - 1742-5247 (Linking)
VI  - 20
IP  - 5
DP  - 2023 May
TI  - Biphasic drug release from electrospun structures.
PG  - 621-640
LID - 10.1080/17425247.2023.2210834 [doi]
AB  - INTRODUCTION: Biphasic release, as a special drug-modified release profile that 
      combines immediate and sustained release, allows fast therapeutic action and 
      retains blood drug concentration for long periods. Electrospun nanofibers, 
      particularly those with complex nanostructures produced by multi-fluid 
      electrospinning processes, are potential novel biphasic drug delivery systems 
      (DDSs). AREAS COVERED: This review summarizes the most recent developments in 
      electrospinning and related structures. In this review, the role of electrospun 
      nanostructures in biphasic drug release was comprehensively explored. These 
      electrospun nanostructures include monolithic nanofibers obtained through 
      single-fluid blending electrospinning, core-shell and Janus nanostructures 
      prepared via bifluid electrospinning, three-compartment nanostructures obtained 
      via trifluid electrospinning, nanofibrous assemblies obtained through the 
      layer-by-layer deposition of nanofibers, and the combined structure of 
      electrospun nanofiber mats with casting films. The strategies and mechanisms 
      through which complex structures facilitate biphasic release were analyzed. 
      EXPERT OPINION: Electrospun structures can provide many strategies for the 
      development of biphasic drug release DDSs. However, many issues such as the 
      scale-up productions of complex nanostructures, the in vivo verification of the 
      biphasic release effects, keeping pace with the developments of multi-fluid 
      electrospinning, drawing support from the state-of-the-art pharmaceutical 
      excipients, and the combination with traditional pharmaceutical methods need to 
      be addressed for real applications.
FAU - Zhou, Jianfeng
AU  - Zhou J
AD  - School of Materials and Chemistry, University of Shanghai for Science and 
      Technology, Shanghai, China.
FAU - Wang, Pu
AU  - Wang P
AD  - School of Materials and Chemistry, University of Shanghai for Science and 
      Technology, Shanghai, China.
FAU - Yu, Deng-Guang
AU  - Yu DG
AUID- ORCID: 0000-0001-7825-4498
AD  - School of Materials and Chemistry, University of Shanghai for Science and 
      Technology, Shanghai, China.
FAU - Zhu, Yuanjie
AU  - Zhu Y
AD  - Department of Dermatology, Naval Medical Center, Naval Medical University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230508
PL  - England
TA  - Expert Opin Drug Deliv
JT  - Expert opinion on drug delivery
JID - 101228421
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Drug Liberation
MH  - Drug Delivery Systems
MH  - *Nanostructures
MH  - *Nanofibers/chemistry
MH  - Pharmaceutical Preparations
OTO - NOTNLM
OT  - Biphasic release
OT  - drug delivery
OT  - electrospinning
OT  - mechanism
OT  - nanostructures
OT  - polymer
EDAT- 2023/05/04 12:42
MHDA- 2023/06/19 13:08
CRDT- 2023/05/04 07:23
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/05/04 12:42 [pubmed]
PHST- 2023/05/04 07:23 [entrez]
AID - 10.1080/17425247.2023.2210834 [doi]
PST - ppublish
SO  - Expert Opin Drug Deliv. 2023 May;20(5):621-640. doi: 
      10.1080/17425247.2023.2210834. Epub 2023 May 8.