PMID- 37140894
OWN - NLM
STAT- MEDLINE
DCOM- 20230621
LR  - 20230621
IS  - 1532-7914 (Electronic)
IS  - 0163-5581 (Linking)
VI  - 75
IP  - 6
DP  - 2023
TI  - Predictive Impact of Prognostic Nutritional Index in Patients with Cancer Treated 
      with Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.
PG  - 1413-1426
LID - 10.1080/01635581.2023.2203355 [doi]
AB  - A few previous studies have investigated the prognostic value of the prognostic 
      nutritional index (PNI) in patients treated with immune checkpoint inhibitors 
      (ICIs); however, the results are inconsistent. Therefore, this study aimed to 
      clarify the prognostic significance of PNI. The PubMed, Embase, and Cochrane 
      Library databases were searched. A meta-analysis of the impact of PNI on overall 
      survival (OS), progression-free survival (PFS), objective response rate (ORR), 
      disease control rate (DCR), and rate of adverse events (AEs) in patients treated 
      with ICIs was performed. Twenty-three studies involving 2,386 patients were 
      included. Low PNI was associated with significantly poor OS (hazard ratio 
      [HR] = 2.26, 95% confidence interval [CI]: 1.81-2.82, P < .001) and short PFS (HR 
      = 1.75, 95% CI: 1.54-1.99, P < .001). Patients with low PNI tended to have a low 
      ORR (odds ratio [OR] = 0.47, 95% CI: 0.34-0.65, P < .001) and DCR (OR = 0.43, 95% 
      CI: 0.34-0.56, P < .001). However, the subgroup analysis demonstrated no 
      significant association between PNI and survival time in patients receiving a 
      programmed death ligand-1 inhibitor. PNI was significantly associated with 
      survival time and treatment efficacy in patients treated with ICIs.
FAU - Xu, Xin-Tian
AU  - Xu XT
AD  - Department of Pharmacy, Hubei Cancer Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, PR China.
FAU - Qian, Yu
AU  - Qian Y
AD  - Department of Thoracic Oncology, Hubei Cancer Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
FAU - Tian, Meng-Xing
AU  - Tian MX
AD  - Department of Clinical Nutrition, Hubei Cancer Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
FAU - Ding, Chen-Chen
AU  - Ding CC
AD  - Department of Clinical Nutrition, Hubei Cancer Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
FAU - Guo, Huan
AU  - Guo H
AD  - Department of Clinical Nutrition, Hubei Cancer Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
FAU - Tang, Jing
AU  - Tang J
AD  - Department of Thoracic Oncology, Hubei Cancer Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
FAU - Pi, Guo-Liang
AU  - Pi GL
AD  - Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
FAU - Wu, Yuan
AU  - Wu Y
AD  - Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
FAU - Dai, Zhu
AU  - Dai Z
AD  - Department of Clinical Nutrition, Hubei Cancer Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
FAU - Jin, Xin
AU  - Jin X
AD  - Department of Clinical Nutrition, Hubei Cancer Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20230504
PL  - United States
TA  - Nutr Cancer
JT  - Nutrition and cancer
JID - 7905040
RN  - 0 (Immune Checkpoint Inhibitors)
SB  - IM
MH  - Humans
MH  - *Nutrition Assessment
MH  - Prognosis
MH  - Immune Checkpoint Inhibitors/adverse effects
MH  - *Neoplasms/drug therapy
MH  - Treatment Outcome
EDAT- 2023/05/04 12:42
MHDA- 2023/06/21 06:42
CRDT- 2023/05/04 11:23
PHST- 2023/06/21 06:42 [medline]
PHST- 2023/05/04 12:42 [pubmed]
PHST- 2023/05/04 11:23 [entrez]
AID - 10.1080/01635581.2023.2203355 [doi]
PST - ppublish
SO  - Nutr Cancer. 2023;75(6):1413-1426. doi: 10.1080/01635581.2023.2203355. Epub 2023 
      May 4.