PMID- 37142210 OWN - NLM STAT- MEDLINE DCOM- 20230601 LR - 20230601 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 330 DP - 2023 Aug 1 TI - Urinary phthalate metabolites and heart rate variability: A panel study. PG - 121760 LID - S0269-7491(23)00762-5 [pii] LID - 10.1016/j.envpol.2023.121760 [doi] AB - Phthalates exposure is linked with cardiovascular disease. Decreased heart rate variability (HRV) is an early indicator of cardiac autonomic imbalance. We conducted a longitudinal panel study in 127 Chinese adults with 3 repeated visits to explore the associations of individual and mixtures of phthalates exposure with HRV. We quantified 10 urinary phthalate metabolites by gas chromatograph-tandem mass spectrometer (GC-MS/MS) and 6 HRV indices by 3-channel digital Holter monitors. Linear mixed-effect (LME) models and Bayesian kernel machine regression (BKMR) models were separately implemented to evaluate the associations. After multivariate adjustments, we found that urinary mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), and mono-n-butyl phthalate (MBP) at lag 0 day were inversely associated with low-frequency power (LF) or total power (TP) (all P-FDR <0.05). In mixture analysis, we observed negative overall associations of phthalate mixtures at lag 0 day with LF or TP, and MiBP was the major contributor. Moreover, stratified analysis suggested that the inverse relationships of MiBP at lag 0 day with LF and TP were more prominent in subjects aged >50 years (all P(interaction) < 0.01). Our findings revealed that exposure to individual and mixtures of phthalates, especially MiBP, were related to decreased HRV. CI - Copyright (c) 2023 Elsevier Ltd. All rights reserved. FAU - Zhang, Ziqian AU - Zhang Z AD - Department of Occupational and Environmental Health, Key Laboratory of Environment & Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Liu, Miao AU - Liu M AD - Department of Epidemiology, School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen, Guangdong, China. FAU - Zhao, Lei AU - Zhao L AD - Department of Occupational and Environmental Health, Key Laboratory of Environment & Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Liu, Linlin AU - Liu L AD - Department of Occupational and Environmental Health, Key Laboratory of Environment & Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Guo, Wenting AU - Guo W AD - Department of Occupational and Environmental Health, Key Laboratory of Environment & Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yu, Jie AU - Yu J AD - Department of Occupational and Environmental Health, Key Laboratory of Environment & Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yang, Huihua AU - Yang H AD - Department of Occupational and Environmental Health, Key Laboratory of Environment & Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Lai, Xuefeng AU - Lai X AD - Department of Occupational and Environmental Health, Key Laboratory of Environment & Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Zhang, Xiaomin AU - Zhang X AD - Department of Occupational and Environmental Health, Key Laboratory of Environment & Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yang, Liangle AU - Yang L AD - Department of Occupational and Environmental Health, Key Laboratory of Environment & Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: yangliangle@sina.cn. LA - eng PT - Journal Article DEP - 20230502 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 6O7F7IX66E (phthalic acid) RN - 0 (mono-isobutyl phthalate) RN - 0 (Phthalic Acids) RN - 0 (Environmental Pollutants) SB - IM MH - Adult MH - Humans MH - Environmental Exposure/analysis MH - Heart Rate MH - Bayes Theorem MH - Tandem Mass Spectrometry MH - *Phthalic Acids/metabolism MH - *Environmental Pollutants/metabolism OTO - NOTNLM OT - Bayesian kernel machine regression OT - Heart rate variability OT - Panel study OT - Phthalate mixtures COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/05/05 00:42 MHDA- 2023/06/01 06:42 CRDT- 2023/05/04 19:29 PHST- 2022/06/24 00:00 [received] PHST- 2023/04/30 00:00 [revised] PHST- 2023/05/01 00:00 [accepted] PHST- 2023/06/01 06:42 [medline] PHST- 2023/05/05 00:42 [pubmed] PHST- 2023/05/04 19:29 [entrez] AID - S0269-7491(23)00762-5 [pii] AID - 10.1016/j.envpol.2023.121760 [doi] PST - ppublish SO - Environ Pollut. 2023 Aug 1;330:121760. doi: 10.1016/j.envpol.2023.121760. Epub 2023 May 2.