PMID- 37145072
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230508
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 69
IP  - 5
DP  - 2023 May 1
TI  - Association between HLA class II Polymorphism and Knee Osteoarthritis in a Thai 
      Population.
LID - 10.7754/Clin.Lab.2022.220920 [doi]
AB  - BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease commonly found 
      among elderly populations. Multiple risk factors, including non-clinical and 
      genetic factors, contribute to the etiology and pathogenesis of OA. This study 
      aimed to investigate the association between the human leukocyte antigen (HLA) 
      class II alleles and knee OA occurrence in a Thai population. METHODS: HLA-DRB1 
      and -DQB1 alleles in 117 patients with knee OA and 84 controls were determined 
      using the PCR with sequence-specific primer (PCR-SSP) method. The association 
      between knee OA and the presence of certain HLA class II alleles was 
      investigated. RESULTS: DRB1*07 and DRB1*09 frequencies increased, while DRB1*14, 
      DRB1*15, and DRB1*12 decreased among patients compared with controls. DQB1*03 
      (DQ9) and DQB1*02 frequencies increased, while DQB1*05 decreased among patients. 
      Notably, the DRB1*14 allele significant decreased (5.6% vs. 11.3%, p = 0.039, OR 
      = 0.461, 95% CI: 0.221 - 0.963), while the DQB1*03 (DQ9) allele significantly 
      increased among patients compared with controls (14.1% vs. 7.1%, p = 0.032, OR = 
      2.134, 95% CI: 1.067 - 4.265). Moreover, the DRB1*14-DQB1*05 haplotype showed a 
      significant protective effect on knee OA (p = 0.039, OR = 0.461, 95% CI: 0.221 - 
      0.963). A contrary effect of HLA-DQB1*03 (DQ9) and HLA-DRB1*14 was observed, 
      wherein the presence of HLA-DQB1*03 (DQ9) seemed to promote disease 
      susceptibility, whereas HLA-DRB1*14 appeared to protect against knee OA. 
      CONCLUSIONS: Knee OA was more pronounced among females than males, especially 
      those aged  60 years. In addition, a contrary effect was found regarding 
      HLA-DQB1*03 (DQ9) and HLA-DRB1*14, in whom the presence of HLA-DQB1*03 (DQ9) 
      seems to promote disease susceptibility, whereas HLA-DRB1*14 appears to be a 
      protective factor against knee OA. However, further study with a larger sample 
      size is suggested.
FAU - Nathalang, Oytip
AU  - Nathalang O
FAU - Intharanut, Kamphon
AU  - Intharanut K
FAU - Apipongrat, Dollapak
AU  - Apipongrat D
FAU - Suttanon, Plaiwan
AU  - Suttanon P
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Male
MH  - Aged
MH  - Female
MH  - Humans
MH  - HLA-DRB1 Chains/genetics
MH  - Gene Frequency
MH  - *Osteoarthritis, Knee/genetics
MH  - Southeast Asian People
MH  - Haplotypes
MH  - Genetic Predisposition to Disease
MH  - Alleles
EDAT- 2023/05/05 12:42
MHDA- 2023/05/08 10:17
CRDT- 2023/05/05 10:35
PHST- 2023/05/08 10:17 [medline]
PHST- 2023/05/05 12:42 [pubmed]
PHST- 2023/05/05 10:35 [entrez]
AID - 10.7754/Clin.Lab.2022.220920 [doi]
PST - ppublish
SO  - Clin Lab. 2023 May 1;69(5). doi: 10.7754/Clin.Lab.2022.220920.