PMID- 37145590
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230517
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 12
IP  - 5
DP  - 2023 May 1
TI  - Correlation Between Coronary and Retinal Microangiopathy in Patients With STEMI.
PG  - 8
LID - 10.1167/tvst.12.5.8 [doi]
LID - 8
AB  - PURPOSE: To investigate the morphological and functional correlation between 
      microvascular retinal changes in optical coherence tomography angiography (OCTA) 
      and the microvascular coronary circulation in patients with ST elevation 
      myocardial infarction (STEMI) coronary heart disease (CHD). METHODS: A total of 
      330 eyes from 165 participants (88 cases and 77 controls) were enrolled and 
      imaged. Superficial capillary plexus (SCP) and deep capillary plexus (DCP) 
      vascular density was measured in the central (1 mm) and perifoveal (1-3 mm) areas 
      and in the superficial foveal avascular zone (FAZ) and choriocapillaris (3 mm). 
      These parameters were then correlated to the left ventricular ejection fraction 
      (LVEF), and the number of affected coronary arteries. RESULTS: Decreased vessel 
      densities in the SCP and DCP and choriocapillaris were positively correlated to 
      the LVEF values (P = 0.006, P = 0.026, and P = 0.002, respectively). No 
      statistically significant correlation between the SCP and DCP central area or FAZ 
      area was found. Regarding the number of affected vessels, significant negative 
      correlations were revealed for the SCP and DCP central vessel densities (P < 
      0.001 and P < 0.001, respectively) and the SCP perifoveal vascular density (P = 
      0.009). CONCLUSIONS: OCTA vascular indices are significantly correlated with 
      morphological and functional parameters in patients with STEMI CHD. SCP vascular 
      density especially seems to be a promising biomarker for the extent of both 
      macrovascular damage (number of affected coronary arteries) and microvascular 
      damage, as mirrored in the decreased LVEF at admission. TRANSLATIONAL RELEVANCE: 
      OCTA vascular indices offer a valuable insight into the microvascular status of 
      coronary circulation.
FAU - Sideri, Anna-Maria
AU  - Sideri AM
AD  - School of Medicine, National and Kapodistrian University of Athens, 1st 
      University Eye Clinic, G. Gennimatas General Hospital of Athens, Athens, Greece.
FAU - Kanakis, Menelaos
AU  - Kanakis M
AD  - School of Medicine, University of Patras, University Eye Clinic, Rion University 
      Hospital, Patras, Greece.
FAU - Katsimpris, Andreas
AU  - Katsimpris A
AD  - School of Medicine, National and Kapodistrian University of Athens, 1st 
      University Eye Clinic, G. Gennimatas General Hospital of Athens, Athens, Greece.
FAU - Karamaounas, Aristotelis
AU  - Karamaounas A
AD  - School of Medicine, National and Kapodistrian University of Athens, 1st 
      University Eye Clinic, G. Gennimatas General Hospital of Athens, Athens, Greece.
FAU - Brouzas, Dimitrios
AU  - Brouzas D
AD  - School of Medicine, National and Kapodistrian University of Athens, 1st 
      University Eye Clinic, G. Gennimatas General Hospital of Athens, Athens, Greece.
FAU - Petrou, Petros
AU  - Petrou P
AD  - School of Medicine, National and Kapodistrian University of Athens, 1st 
      University Eye Clinic, G. Gennimatas General Hospital of Athens, Athens, Greece.
FAU - Papakonstaninou, Evangelia
AU  - Papakonstaninou E
AD  - School of Medicine, National and Kapodistrian University of Athens, 1st 
      University Eye Clinic, G. Gennimatas General Hospital of Athens, Athens, Greece.
FAU - Droutsas, Konstantinos
AU  - Droutsas K
AD  - School of Medicine, National and Kapodistrian University of Athens, 1st 
      University Eye Clinic, G. Gennimatas General Hospital of Athens, Athens, Greece.
FAU - Kandarakis, Stylianos
AU  - Kandarakis S
AD  - School of Medicine, National and Kapodistrian University of Athens, 1st 
      University Eye Clinic, G. Gennimatas General Hospital of Athens, Athens, Greece.
FAU - Giannopoulos, Georgios
AU  - Giannopoulos G
AD  - 3rd Department of Cardiology, School of Medicine, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
FAU - Georgalas, Ilias
AU  - Georgalas I
AD  - School of Medicine, National and Kapodistrian University of Athens, 1st 
      University Eye Clinic, G. Gennimatas General Hospital of Athens, Athens, Greece.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
SB  - IM
MH  - Humans
MH  - *ST Elevation Myocardial Infarction/diagnostic imaging
MH  - Retinal Vessels/diagnostic imaging
MH  - Fluorescein Angiography/methods
MH  - Stroke Volume
MH  - Fundus Oculi
MH  - Ventricular Function, Left
PMC - PMC10168007
COIS- Disclosure: A.-M. Sideri, None; M. Kanakis, None; A. Katsimpris, None; A. 
      Karamaounas, None; D. Brouzas, None; P. Petrou, None; E. Papakonstaninou, None; 
      K. Droutsas, None; S. Kandarakis, None; G. Giannopoulos, None; I. Georgalas, None
EDAT- 2023/05/05 12:42
MHDA- 2023/05/08 06:41
PMCR- 2023/05/05
CRDT- 2023/05/05 11:33
PHST- 2023/05/08 06:41 [medline]
PHST- 2023/05/05 12:42 [pubmed]
PHST- 2023/05/05 11:33 [entrez]
PHST- 2023/05/05 00:00 [pmc-release]
AID - 2785599 [pii]
AID - TVST-22-4605 [pii]
AID - 10.1167/tvst.12.5.8 [doi]
PST - ppublish
SO  - Transl Vis Sci Technol. 2023 May 1;12(5):8. doi: 10.1167/tvst.12.5.8.