PMID- 37147659
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230622
IS  - 2072-1315 (Electronic)
IS  - 1606-0997 (Print)
IS  - 1606-0997 (Linking)
VI  - 42
IP  - 1
DP  - 2023 May 5
TI  - Inflammatory biomarkers in overweight and obese Iranian women are associated with 
      polyphenol intake.
PG  - 39
LID - 10.1186/s41043-023-00376-4 [doi]
LID - 39
AB  - BACKGROUND: The evidence shows that obesity is associated with chronic 
      inflammation in obese subjects. Polyphenols are a complex group of plant 
      secondary metabolites that may play a role in reducing the risk of obesity and 
      obesity-related diseases. Given the scarcity of evidence on the association 
      between inflammatory markers and dietary polyphenols intake in overweight/obese 
      Iranian women, the current study aims to investigate this link. METHOD: The 
      present cross-sectional study was conducted on 391 overweight and obese Iranian 
      women aged 18-48 years (body mass index (BMI) >/= 25 kg/m(2)). A 147-item food 
      frequency questionnaire (FFQ) was used to assess dietary intake, as well as 
      anthropometric indices including weight, height, waist circumference (WC), and 
      hip circumference (HC) and biochemistry parameters including triglyceride (TG), 
      total cholesterol (Chole), low-density lipoprotein cholesterol (LDL-c), 
      high-density lipoprotein cholesterol (HDL-c), serum glutamic pyruvic transaminase 
      (SGPT), serum glutamic-oxaloacetic transaminase (SGOT), galactin-3 (Gal-3), 
      monocyte chemoattractant protein-1 (MCP-1), transforming growth factor beta 
      (TGF-beta), interleukin-1 beta (IL_1beta), plasminogen activator inhibitor-1 (PA-I), 
      serum leptin concentrations, and C-reactive protein of high sensitivity (hs-CRP) 
      in all participants. The inflammatory markers were assessed using the 
      enzyme-linked immunosorbent assay (ELISA). RESULT: The findings revealed a 
      significant negative association between flavonoids intake and MCP-1 (P = 0.024), 
      lignans intake and MCP-1 (P = 0.017), and Gal-3 (P = 0.032). These significant 
      associations were observed between other polyphenols intake and IL_1beta 
      (P = 0.014). There was also a significant positive association between other 
      polyphenol intake and TGF-beta (P = 0.008) and between phenolic acid intake and 
      TGF-beta (P = 0.014). CONCLUSION: Our findings suggest that a high polyphenol intake 
      may help individuals to reduce systemic inflammation. Further large studies 
      involving participants of different ages and genders are highly warranted.
CI  - (c) 2023. The Author(s).
FAU - Shiraseb, Farideh
AU  - Shiraseb F
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
FAU - Hosseininasab, Dorsa
AU  - Hosseininasab D
AD  - Department of Nutrition, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran.
FAU - Noori, Sahar
AU  - Noori S
AD  - Department of Nutrition, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran.
FAU - Ebrahimi, Sara
AU  - Ebrahimi S
AD  - The Ritchie Centre, Hudson Institute of Medical Research, Monash University, 
      Clayton, Melbourne, VIC, Australia.
FAU - Asjodi, Foad
AU  - Asjodi F
AD  - IFMARK, FIFA Medical Center of Excellence, Tehran, Iran.
FAU - Ghaffarian-Ensaf, Rasool
AU  - Ghaffarian-Ensaf R
AD  - Department of Nutrition, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran.
FAU - Carnauba, Renata A
AU  - Carnauba RA
AD  - Department of Food Science and Experimental Nutrition, School of Pharmaceutical 
      Sciences, University of Sao Paulo, Sao Paulo, Brazil.
AD  - Food Research Center, CEPID-FAPESP (Research Innovation and Dissemination 
      Centers, Sao Paulo Research Foundation), Sao Paulo, Brazil.
FAU - Mirzaei, Khadijeh
AU  - Mirzaei K
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran. 
      mirzaei_kh@sina.tums.ac.ir.
AD  - Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. mirzaei_kh@sina.tums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230505
PL  - Bangladesh
TA  - J Health Popul Nutr
JT  - Journal of health, population, and nutrition
JID - 100959228
RN  - 0 (Polyphenols)
RN  - 0 (Biomarkers)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - *Overweight/complications
MH  - Iran
MH  - *Polyphenols
MH  - Cross-Sectional Studies
MH  - Obesity/complications
MH  - Biomarkers
MH  - Body Mass Index
MH  - Inflammation
MH  - Cholesterol
MH  - Transforming Growth Factor beta
PMC - PMC10161422
OTO - NOTNLM
OT  - C-reactive protein
OT  - Inflammation
OT  - Obesity
OT  - Polyphenols
OT  - TGF-beta
COIS- All authors declared that they have no competing interests.
EDAT- 2023/05/06 09:41
MHDA- 2023/05/08 06:42
PMCR- 2023/05/05
CRDT- 2023/05/05 23:38
PHST- 2023/01/23 00:00 [received]
PHST- 2023/04/08 00:00 [accepted]
PHST- 2023/05/08 06:42 [medline]
PHST- 2023/05/06 09:41 [pubmed]
PHST- 2023/05/05 23:38 [entrez]
PHST- 2023/05/05 00:00 [pmc-release]
AID - 10.1186/s41043-023-00376-4 [pii]
AID - 376 [pii]
AID - 10.1186/s41043-023-00376-4 [doi]
PST - epublish
SO  - J Health Popul Nutr. 2023 May 5;42(1):39. doi: 10.1186/s41043-023-00376-4.