PMID- 37147786 OWN - NLM STAT- MEDLINE DCOM- 20230814 LR - 20230907 IS - 2324-9269 (Electronic) IS - 2324-9269 (Linking) VI - 11 IP - 8 DP - 2023 Aug TI - Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar. PG - e2178 LID - 10.1002/mgg3.2178 [doi] LID - e2178 AB - BACKGROUND: Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). OBJECTIVE: The study aimed to investigate the association between selected single nucleotide polymorphisms (SNPs) with dyslipidemia and increased susceptibility risks of CVD, NAFLD, and/or T2DM in dyslipidemia patients in comparison with healthy control individuals from the Qatar genome project. METHODS: A community-based cross-sectional study was conducted among 2933 adults (859 dyslipidemia patients and 2074 healthy control individuals) from April to December 2021 to investigate the association between 331 selected SNPs with dyslipidemia and increased susceptibility risks of CVD, NAFLD and/or T2DM, and covariates. RESULTS: The genotypic frequencies of six SNPs were found to be significantly different in dyslipidemia patients subjects compared to the control group among males and females. In males, three SNPs were found to be significant, the rs11172113 in over-dominant model, the rs646776 in recessive and over-dominant models, and the rs1111875 in dominant model. On the other hand, two SNPs were found to be significant in females, including rs2954029 in recessive model, and rs1801251 in dominant and recessive models. The rs17514846 SNP was found for dominant and over-dominant models among males and only the dominant model for females. We found that the six SNPs linked to gender type had an influence in relation to disease susceptibility. When controlling for the four covariates (gender, obesity, hypertension, and diabetes), the difference between dyslipidemia and the control group remained significant for the six variants. Finally, males were three times more likely to have dyslipidemia in comparison with females, hypertension was two times more likely to be present in the dyslipidemia group, and diabetes was six times more likely to be in the dyslipidemia group. CONCLUSION: The current investigation provides evidence of association for a common SNP to coronary heart disease and suggests a sex-dependent effect and encourage potential therapeutic applications. CI - (c) 2023 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC. FAU - Al-Sharshani, Dalal AU - Al-Sharshani D AD - Heart Hospital (HH), Hamad Medical Corporation (HMC), Doha, Qatar. AD - Genomics and Precision Medicine (GPM), College of Health & Life Science (CHLS), Hamad Bin Khalifa University (HBKU), Doha, Qatar. FAU - Velayutham, Dinesh AU - Velayutham D AD - Liberal Arts and Science (LAS), Hamad Bin Khalifa University (HBKU), Doha, Qatar. FAU - Samara, Muthanna AU - Samara M AD - Department of Psychology, Kingston University London, Kingston upon Thames, London, UK. FAU - Gazal, Reham AU - Gazal R AD - Department of Research, Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, Qatar. FAU - Al Haj Zen, Ayman AU - Al Haj Zen A AD - College of Health & Life Science (CHLS), Hamad Bin Khalifa University (HBKU), Doha, Qatar. FAU - Ismail, Mohamed A AU - Ismail MA AD - Hamad Medical Corporation (HMC), Doha, Qatar. FAU - Ahmed, Mahmoud AU - Ahmed M AD - Department of Mathematics, Statistics and Physics, College of Arts and Sciences, Qatar University (QU), Doha, Qatar. FAU - Nasrallah, Gheyath AU - Nasrallah G AD - Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University (QU), Doha, Qatar. FAU - Younes, Salma AU - Younes S AD - Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University (QU), Doha, Qatar. FAU - Rizk, Nasser AU - Rizk N AD - Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University (QU), Doha, Qatar. FAU - Hammuda, Sara AU - Hammuda S AD - Department of Psychology, Kingston University London, Kingston upon Thames, London, UK. FAU - Qoronfleh, M Walid AU - Qoronfleh MW AD - Research & Policy Division, Q3CG Research Institute (QRI), 7227 Rachel Drive, Ypsilanti, Michigan, USA. AD - 21HealthStreet Company, London, UK. FAU - Farrell, Thomas AU - Farrell T AD - Department of Research, Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, Qatar. FAU - Zayed, Hatem AU - Zayed H AD - Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University (QU), Doha, Qatar. FAU - Abdulrouf, Palli Valapila AU - Abdulrouf PV AD - Department of Research, Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, Qatar. FAU - AlDweik, Manar AU - AlDweik M AD - Department of Research, Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, Qatar. FAU - Silang, John Paul Ben AU - Silang JPB AD - Department of Research, Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, Qatar. FAU - Rahhal, Alaa AU - Rahhal A AD - Heart Hospital (HH), Hamad Medical Corporation (HMC), Doha, Qatar. FAU - Al-Jurf, Rana AU - Al-Jurf R AD - Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University (QU), Doha, Qatar. FAU - Mahfouz, Ahmed AU - Mahfouz A AUID- ORCID: 0000-0002-6253-1670 AD - Heart Hospital (HH), Hamad Medical Corporation (HMC), Doha, Qatar. FAU - Salam, Amar AU - Salam A AD - Department of Cardiology, Al Khor Hospital (AKH), Hamad Medical Corporation (HMC), Doha, Qatar. FAU - Al Rifai, Hilal AU - Al Rifai H AD - Neonatal Intensive Care Unit (NICU), Newborn Screening Unit, Department of Pediatrics and Neonatology, Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, Qatar. FAU - Al-Dewik, Nader I AU - Al-Dewik NI AUID- ORCID: 0000-0001-5739-1135 AD - Genomics and Precision Medicine (GPM), College of Health & Life Science (CHLS), Hamad Bin Khalifa University (HBKU), Doha, Qatar. AD - Department of Research, Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, Qatar. AD - Hamad Medical Corporation (HMC), Doha, Qatar. AD - Neonatal Intensive Care Unit (NICU), Newborn Screening Unit, Department of Pediatrics and Neonatology, Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, Qatar. AD - Faculty of Health and Social Care Sciences, Kingston University, St. George's University of London, London, UK. AD - Translational and Precision Medicine Research, Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, Qatar. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230505 PL - United States TA - Mol Genet Genomic Med JT - Molecular genetics & genomic medicine JID - 101603758 SB - IM MH - Adult MH - Male MH - Female MH - Humans MH - Polymorphism, Single Nucleotide MH - *Diabetes Mellitus, Type 2/genetics MH - *Non-alcoholic Fatty Liver Disease MH - Qatar/epidemiology MH - Cross-Sectional Studies MH - *Hypertension MH - *Cardiovascular Diseases/epidemiology/genetics/complications MH - *Dyslipidemias/epidemiology/genetics/complications PMC - PMC10422074 OTO - NOTNLM OT - Qatar genome project (QGP) OT - cardiovascular disease (CVD) OT - coronary artery disease (CAD) OT - diabetes OT - dyslipidemia OT - hypertension OT - metabolic OT - non-alcoholic fatty liver disease (NAFLD) OT - single nucleotide polymorphism (SNP) COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/05/06 09:42 MHDA- 2023/08/14 06:42 PMCR- 2023/05/05 CRDT- 2023/05/06 01:02 PHST- 2023/03/10 00:00 [revised] PHST- 2022/11/04 00:00 [received] PHST- 2023/03/15 00:00 [accepted] PHST- 2023/08/14 06:42 [medline] PHST- 2023/05/06 09:42 [pubmed] PHST- 2023/05/06 01:02 [entrez] PHST- 2023/05/05 00:00 [pmc-release] AID - MGG32178 [pii] AID - 10.1002/mgg3.2178 [doi] PST - ppublish SO - Mol Genet Genomic Med. 2023 Aug;11(8):e2178. doi: 10.1002/mgg3.2178. Epub 2023 May 5.