PMID- 37147916
OWN - NLM
STAT- MEDLINE
DCOM- 20230726
LR  - 20230726
IS  - 1464-5246 (Electronic)
IS  - 0265-2048 (Linking)
VI  - 40
IP  - 5
DP  - 2023 Dec
TI  - The protective effect of N-acetylcysteine against liposome and chitosan-induced 
      cytotoxicity.
PG  - 357-365
LID - 10.1080/02652048.2023.2209646 [doi]
AB  - AIM: N-acetylcysteine (NAC) is an antioxidant used to moderate liposome and 
      chitosan-induced cell cytotoxicity at their high concentrations. METHODS: 
      Liposome and chitosan were prepared and characterised. The cytotoxicity effect of 
      liposome with NAC-loaded liposome (liposome-NAC) and chitosan solution with 
      chitosan solution containing NAC (chitosan-NAC) on the A549 cell line was 
      compared. RESULTS: Particle size, zeta potential, and NAC drug release for 
      liposome were 125.9 +/- 8 nm, -34.7 +/- 2.1 mV, and 51.1% +/- 3%, respectively. 
      Scanning electron microscope (SEM) and transmission electron microscope (TEM) 
      indicated spherical shape of liposome. Encapsulation efficiency of liposome-NAC 
      was 12% +/- 0.98%. Particle size and zeta potential for chitosan solution were 
      361 +/- 11.3 nm and 10.8 +/- 1.52 mV. Stability storage study indicated good 
      stability of chitosan and liposome. Cell viability of liposome-NAC and 
      chitosan-NAC significantly was higher than liposome and chitosan at all four 
      concentrations. CONCLUSIONS: NAC has a protective effect against liposome and 
      chitosan-induced cell toxicity.
FAU - Hamedinasab, Hamed
AU  - Hamedinasab H
AD  - Division of Nanobiotechnology, Department of Life Science Engineering, Faculty of 
      New Sciences and Technologies, University of Tehran, Tehran, Iran.
FAU - Rezayan, Ali Hossein
AU  - Rezayan AH
AD  - Division of Nanobiotechnology, Department of Life Science Engineering, Faculty of 
      New Sciences and Technologies, University of Tehran, Tehran, Iran.
FAU - Jaafari, Mahmoud Reza
AU  - Jaafari MR
AUID- ORCID: 0000-0003-3908-6828
AD  - Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Mashreghi, Mohammad
AU  - Mashreghi M
AD  - Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Alvandi, Hale
AU  - Alvandi H
AD  - Division of Nanobiotechnology, Department of Life Science Engineering, Faculty of 
      New Sciences and Technologies, University of Tehran, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230519
PL  - England
TA  - J Microencapsul
JT  - Journal of microencapsulation
JID - 8500513
RN  - WYQ7N0BPYC (Acetylcysteine)
RN  - 0 (Antioxidants)
RN  - 9012-76-4 (Chitosan)
RN  - 0 (Liposomes)
SB  - IM
MH  - Acetylcysteine/pharmacology
MH  - Antioxidants
MH  - *Chitosan/toxicity
MH  - Drug Liberation
MH  - Liposomes
MH  - *Nanoparticles
MH  - Particle Size
OTO - NOTNLM
OT  - Liposome
OT  - N-acetylcysteine
OT  - chitosan
OT  - cytotoxicity
OT  - drug delivery
EDAT- 2023/05/06 09:42
MHDA- 2023/07/18 13:10
CRDT- 2023/05/06 03:53
PHST- 2023/07/18 13:10 [medline]
PHST- 2023/05/06 09:42 [pubmed]
PHST- 2023/05/06 03:53 [entrez]
AID - 10.1080/02652048.2023.2209646 [doi]
PST - ppublish
SO  - J Microencapsul. 2023 Dec;40(5):357-365. doi: 10.1080/02652048.2023.2209646. Epub 
      2023 May 19.