PMID- 37147933 OWN - NLM STAT- MEDLINE DCOM- 20230608 LR - 20230611 IS - 1751-7176 (Electronic) IS - 1524-6175 (Print) IS - 1524-6175 (Linking) VI - 25 IP - 6 DP - 2023 Jun TI - Association between body fat composition and hyperhomocysteinemia in the analysis of the baseline data of the Northwest China Natural Population Cohort: Ningxia Project (CNC-NX). PG - 573-581 LID - 10.1111/jch.14666 [doi] AB - The authors conducted an observational study to explore the association between body fat composition and the risk of hyperhomocysteinemia (HHcy) and their combined effect on the risk of developing cardiovascular disease (CVD). Adults aged 18-74 years from the Northwest China Natural Population Cohort: Ningxia Project (CNC-NX) were recruited in this study. Association between body fat composition and HHcy was evaluated by logistic regression model. Restricted cubic spline was used to find nonlinear association. The impact of the interaction between HHcy and body fat composition on CVD was evaluated using the addition interaction model and mediation effect model. In total, 16 419 participants were included in this research. Body fat percentage, visceral fat level, and abdominal fat thickness were positively associated with overall HHcy (p for trend < .001). Adjusted odds ratios (ORs) in quarter 4 were 1.181 (95% CI: 1.062, 1.313), 1.202 (95% CI: 1.085, 1.332), and 1.168 (95% CI: 1.055, 1.293) for body fat percentage, visceral fat level, and abdominal fat thickness, respectively, compared with those in quarter 1. Subgroup analysis indicated age, estimated glomerular filtration rate (eGFR), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and CVD were the interaction factors of body fat percentage, visceral fat level, abdominal fat thickness with HHcy (all p for interaction < .05). ORs of CVD were higher in participants with HHcy and high body fat. Body fat composition was positively associated with HHcy, indicating that reducing body, abdominal, and visceral fat content may lower the risk of HHcy and CVD. CI - (c) 2023 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. FAU - Liu, Wanlu AU - Liu W AD - School of Public Health and Management, Ningxia Medical University, Xingqing District, Yinchuan, China. FAU - Li, Qingqing AU - Li Q AD - School of Public Health and Management, Ningxia Medical University, Xingqing District, Yinchuan, China. FAU - Wang, Qingan AU - Wang Q AD - School of Public Health and Management, Ningxia Medical University, Xingqing District, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, China. FAU - Ma, Shengchao AU - Ma S AD - NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, China. AD - Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China. AD - The School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China. FAU - Yang, Xiaoling AU - Yang X AD - NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, China. AD - Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China. AD - The School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China. FAU - Zhang, Jiaxing AU - Zhang J AD - School of Public Health and Management, Ningxia Medical University, Xingqing District, Yinchuan, China. FAU - Qiu, Jiangwei AU - Qiu J AD - School of Public Health and Management, Ningxia Medical University, Xingqing District, Yinchuan, China. FAU - Li, Juan AU - Li J AD - School of Public Health and Management, Ningxia Medical University, Xingqing District, Yinchuan, China. FAU - Yang, Chan AU - Yang C AD - School of Public Health and Management, Ningxia Medical University, Xingqing District, Yinchuan, China. AD - School of Nursing, Ningxia Medical University, Ningxia Medical University, Yinchuan, China. FAU - Li, Xiaoxia AU - Li X AD - School of Public Health and Management, Ningxia Medical University, Xingqing District, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, China. FAU - Zhang, Huiping AU - Zhang H AD - NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, China. AD - Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China. AD - Department of Prenatal Diagnosis, Maternal and Child Health Hospital of Hunan Province, Changsha, China. FAU - Jiang, Yideng AU - Jiang Y AD - NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, China. AD - Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China. AD - The School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China. FAU - Zhang, Yuhong AU - Zhang Y AUID- ORCID: 0000-0002-7110-8401 AD - School of Public Health and Management, Ningxia Medical University, Xingqing District, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, China. FAU - Zhao, Yi AU - Zhao Y AD - School of Public Health and Management, Ningxia Medical University, Xingqing District, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, China. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20230506 PL - United States TA - J Clin Hypertens (Greenwich) JT - Journal of clinical hypertension (Greenwich, Conn.) JID - 100888554 SB - IM MH - Adult MH - Humans MH - Risk Factors MH - *Hyperhomocysteinemia/complications/epidemiology MH - *Hypertension MH - China/epidemiology MH - Adipose Tissue PMC - PMC10246456 OTO - NOTNLM OT - abdominal adipose tissue OT - body fat percentage OT - hyperhomocysteinemia OT - obesity OT - visceral fat COIS- The authors declare no conflict of interest. EDAT- 2023/05/06 09:42 MHDA- 2023/06/08 06:42 PMCR- 2023/05/06 CRDT- 2023/05/06 04:32 PHST- 2023/03/28 00:00 [revised] PHST- 2023/02/28 00:00 [received] PHST- 2023/04/21 00:00 [accepted] PHST- 2023/06/08 06:42 [medline] PHST- 2023/05/06 09:42 [pubmed] PHST- 2023/05/06 04:32 [entrez] PHST- 2023/05/06 00:00 [pmc-release] AID - JCH14666 [pii] AID - 10.1111/jch.14666 [doi] PST - ppublish SO - J Clin Hypertens (Greenwich). 2023 Jun;25(6):573-581. doi: 10.1111/jch.14666. Epub 2023 May 6.