PMID- 37149174
OWN - NLM
STAT- MEDLINE
DCOM- 20230609
LR  - 20230609
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 885
DP  - 2023 Aug 10
TI  - Single and joint associations of exposure to polycyclic aromatic hydrocarbons 
      with blood coagulation function during pregnancy: A cross-sectional study.
PG  - 163949
LID - S0048-9697(23)02570-6 [pii]
LID - 10.1016/j.scitotenv.2023.163949 [doi]
AB  - Association linking polycyclic aromatic hydrocarbons (PAHs) to blood coagulation 
      function during pregnancy remains absent. Hence, we conducted a cross-sectional 
      study including 679 late pregnant women (27.2 +/- 5.1 years old) drawn from Zunyi 
      birth cohort, Southwest China. During late pregnancy, ten urinary PAHs 
      metabolites and four clinical blood coagulation parameters were measured, 
      including activated partial thromboplastin time (APTT), prothrombin time (PT), 
      thrombin time (TT), and fibrinogen (FIB). Multiple linear regression, Restricted 
      cubic spline (RCS) regression, Bayesian kernel machine regression (BKMR), and 
      quantile g-computation (Q-g) regression were used to investigate their single, 
      nonlinear, and mixed associations. Each 2.7-fold increment in 2-hydroxyfluorene 
      (2-OHFlu), 9-hydroxyfluorene (9-OHFlu), 1-hydroxyphenanthrene (1-OHPhe), 
      2-hydroxyphenanthrene (2-OHPhe), and 3-hydroxyphenanthrene (3-OHPhe) were 
      associated with 0.287 s, 0.190 s, 0.487 s, and 0.396 s shorter APTT, 
      respectively; each 2.7-fold increment in 2-OHPhe was associated with a 0.047 s 
      longer PT; each 2.7-fold increment in 9-hydroxyphenanthrene (9-OHPhe) and 
      1-hydroxypyrene (1-OHPyr) were associated with 0.087 s and 0.031 s shorter TT, 
      respectively; and each 2.7-fold increment in 1-hydroxynaphthalene (1-OHNap) was 
      associated with 0.032 g/L higher FIB level. The nonlinear association of 2-OHPhe 
      with APTT and 1-OHNap with FIB were also observed. Furthermore, the shortened 
      APTT and TT associated with PAHs mixture were indicated by BKMR and Q-g model. 
      BKMR also revealed a nonlinear association of 2-OHPhe with PT and an interaction 
      effect of 2-OHPhe and 3-OHPhe on APTT. Our results indicate that urinary PAHs was 
      associated with shortened coagulation time and increased FIB. Therefore, more 
      attention should be paid for late pregnant women to prevent PAHs-associated risk 
      of thrombosis. Future perspective studies to confirm our findings and explore the 
      underlying biological mechanism are warranted.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Luo, Lei
AU  - Luo L
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Zunyi Medical University, Zunyi 563000, China.
FAU - Tian, Kunming
AU  - Tian K
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Zunyi Medical University, Zunyi 563000, China.
FAU - Chen, Yi
AU  - Chen Y
AD  - Department of Obstetrics and Gynecology, Affiliated Hospital of Zunyi Medical 
      University, Zunyi 563000, China.
FAU - Liu, Yijun
AU  - Liu Y
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Zunyi 
      Medical University, Zunyi 563000, Guizhou, China.
FAU - Dai, Mi
AU  - Dai M
AD  - The Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.
FAU - Gong, Liming
AU  - Gong L
AD  - Department of Obstetrics and Gynecology, Affiliated Hospital of Zunyi Medical 
      University, Zunyi 563000, China; Department of Reproductive Medicine, Affiliated 
      Hospital of Zunyi Medical University, Zunyi 563000, China.
FAU - Xiong, Shimin
AU  - Xiong S
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Zunyi 
      Medical University, Zunyi 563000, Guizhou, China.
FAU - Xie, Yan
AU  - Xie Y
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Zunyi Medical University, Zunyi 563000, China.
FAU - Shen, Xubo
AU  - Shen X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Zunyi 
      Medical University, Zunyi 563000, Guizhou, China.
FAU - Zhou, Yuanzhong
AU  - Zhou Y
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Zunyi 
      Medical University, Zunyi 563000, Guizhou, China. Electronic address: 
      zhouyuanzhong@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230504
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Female
MH  - Pregnancy
MH  - Young Adult
MH  - Adult
MH  - *Polycyclic Aromatic Hydrocarbons/urine
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - Prothrombin Time
MH  - Blood Coagulation
MH  - Biomarkers/urine
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Coagulation
OT  - Joint association
OT  - Polycyclic aromatic hydrocarbons
OT  - Pregnancy
OT  - Quantile g-computation
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/05/07 00:42
MHDA- 2023/06/09 06:42
CRDT- 2023/05/06 19:30
PHST- 2023/03/02 00:00 [received]
PHST- 2023/04/24 00:00 [revised]
PHST- 2023/04/30 00:00 [accepted]
PHST- 2023/06/09 06:42 [medline]
PHST- 2023/05/07 00:42 [pubmed]
PHST- 2023/05/06 19:30 [entrez]
AID - S0048-9697(23)02570-6 [pii]
AID - 10.1016/j.scitotenv.2023.163949 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Aug 10;885:163949. doi: 10.1016/j.scitotenv.2023.163949. 
      Epub 2023 May 4.