PMID- 37149273
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230605
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 873
DP  - 2023 Jul 15
TI  - Functional analysis of selenok, selenot and selenop promoters and their 
      regulation by selenium in yellow catfish Pelteobagrus fulvidraco.
PG  - 147461
LID - S0378-1119(23)00302-5 [pii]
LID - 10.1016/j.gene.2023.147461 [doi]
AB  - The selenok, selenot and selenop are three key selenoproteins involved in stress 
      response. Our study, using the yellow catfish Pelteobagrus fulvidraco as the 
      experimental animal, obtained the 1993-bp, 2000-bp and 1959-bp sequences of 
      selenok, selenot and selenop promoters, respectively, and predicted the binding 
      sites of several transcriptional factors on their promoters, such as Forkhead box 
      O 4 (FoxO4), activating transcription factor 4 (ATF4), Kruppel-like factor 4 
      (KLF4) and nuclear factor erythroid 2-related factor 2 (NRF2). Selenium (Se) 
      increased the activities of the selenok, selenot and selenop promoters. FoxO4 and 
      Nrf2 can directly bind with selenok promoter and controlled selenok promoter 
      activities positively; KLF4 and Nrf2 can directly bind with selenot promoter and 
      controlled selenot promoter activities positively; FoxO4 and ATF4 can directly 
      bind to selenop promoter and regulated selenop promoter activities positively. Se 
      promoted FoxO4 and Nrf2 binding to selenok promoter, KLF4 and Nrf2 binding to 
      selenot promoter, and FoxO4 and ATF4 binding to selenop promoter. Thus, we 
      provide the first evidence for FoxO4 and Nrf2 bindnig elements in selenok 
      promoter, KLF4 and Nrf2 binding elements in selenot promoter, and FoxO4 and ATF4 
      binding elements in selenop promoter, and offer novel insight into regulatory 
      mechanism of these selenoproteins induced by Se.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Ke, Jiang
AU  - Ke J
AD  - Hubei Hongshan Laboratory, Fishery College, Huazhong Agriculture University, 
      Wuhan 430070, China.
FAU - Zhang, Dian-Guang
AU  - Zhang DG
AD  - Hubei Hongshan Laboratory, Fishery College, Huazhong Agriculture University, 
      Wuhan 430070, China.
FAU - Liu, Sheng-Zan
AU  - Liu SZ
AD  - Hubei Hongshan Laboratory, Fishery College, Huazhong Agriculture University, 
      Wuhan 430070, China.
FAU - Luo, Zhi
AU  - Luo Z
AD  - Hubei Hongshan Laboratory, Fishery College, Huazhong Agriculture University, 
      Wuhan 430070, China; Shenzhen Institute of Nutrition and Health, Huazhong 
      Agricultural University, China; Shenzhen Branch, Guangdong Laboratory for Lingnan 
      Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, 
      Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural 
      Sciences, Shenzhen, China. Electronic address: luozhi99@mail.hzau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230504
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - H6241UJ22B (Selenium)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Selenoprotein P)
RN  - 0 (Selenoproteins)
SB  - IM
MH  - Animals
MH  - *Selenium/pharmacology
MH  - *Catfishes/genetics/metabolism
MH  - NF-E2-Related Factor 2
MH  - Selenoprotein P
MH  - Selenoproteins/metabolism
OTO - NOTNLM
OT  - Promoter analysis
OT  - Selenium
OT  - Selenoproteins
OT  - Transcriptional regulation
OT  - Vertebrates
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/05/07 00:42
MHDA- 2023/06/05 06:42
CRDT- 2023/05/06 19:32
PHST- 2023/02/03 00:00 [received]
PHST- 2023/04/25 00:00 [revised]
PHST- 2023/05/01 00:00 [accepted]
PHST- 2023/06/05 06:42 [medline]
PHST- 2023/05/07 00:42 [pubmed]
PHST- 2023/05/06 19:32 [entrez]
AID - S0378-1119(23)00302-5 [pii]
AID - 10.1016/j.gene.2023.147461 [doi]
PST - ppublish
SO  - Gene. 2023 Jul 15;873:147461. doi: 10.1016/j.gene.2023.147461. Epub 2023 May 4.