PMID- 37149589
OWN - NLM
STAT- MEDLINE
DCOM- 20230519
LR  - 20230519
IS  - 2662-7671 (Electronic)
IS  - 2662-7671 (Linking)
VI  - 23
IP  - 1
DP  - 2023 May 6
TI  - Protective effects of the Terminalia bellirica tannin-induced Nrf2/HO-1 signaling 
      pathway in rats with high-altitude pulmonary hypertension.
PG  - 150
LID - 10.1186/s12906-023-03981-2 [doi]
LID - 150
AB  - BACKGROUND: Oxidative stress and endothelial cell dysfunction induced by 
      high-altitude hypoxia have important roles in the pathological process of 
      high-altitude pulmonary hypertension (HAPH). Tannins present in Terminalia 
      bellirica (Gaertn.) Roxb. (TTR) have pharmacological activities that produce 
      oxidation resistance and exert anti-inflammatory effects. Whether TTR exerts a 
      protective effect on HAPH remains unknown. METHODS: A rat model of HAPH was 
      established. The mean pulmonary arterial pressure (mPAP) of the animals was 
      measured, the serum levels of SOD, MDA, and GSH-Px were measured using ELISA, and 
      the expression of Bax, Bcl-2, Nrf2, and HO-1 proteins in the lung tissue of each 
      group of rats was measured using Western blotting. Pathological changes in the 
      lung tissue were also observed. A model of damage to H(2)O(2)-induced pulmonary 
      artery endothelial cells (PAECs) was generated, and cell proliferation was 
      measured using CCK-8 assays. Flow cytometry was used to measure ROS levels in 
      PAECs. Western blotting was used to detect the expression of Bax, Bcl-2, Nrf2, 
      and HO-1 proteins in PAECs. RESULTS: The hemodynamic and pathologic findings 
      showed that the mPAP of HAPH rats increased markedly, and the vascular wall 
      thickness increased (P < 0.05). TTR reduced mPAP, alleviated or slowed pulmonary 
      arterial remodeling, increased GSH-Px and SOD activity, lowered the level of MDA 
      (P < 0.05), and downregulated the expression of Bax in the lung tissues of HAPH 
      rats, while the expression of Bcl-2, Nrf2, and HO-1 was upregulated (P < 0.05). 
      The results of the cell experiments showed that TTR inhibited H(2)O(2)-induced 
      PAEC apoptosis and ROS production (P < 0.05), downregulated the expression of Bax 
      in PAECs, and upregulated the expression of Bcl-2, Nrf2, and HO-1 (P < 0.05). 
      CONCLUSION: The results suggest that TTR reduces pulmonary arterial pressure, 
      decreases oxidative stress during HAPH, and exerts protective effects in rats 
      with HAPH and that its mechanism of action is related to regulation of the 
      Nrf2/HO-1 signaling pathway.
CI  - (c) 2023. The Author(s).
FAU - Aimaier, Salamaiti
AU  - Aimaier S
AD  - Heart Center, The First Affiliated Hospital of Xinjiang Medical University, 
      Urumqi, 830054, China.
FAU - Tao, Yang
AU  - Tao Y
AD  - College of pharmacy, Xinjiang Medical University, Urumqi, 830011, China. 
      690579893@qq.com.
AD  - Central Laboratory, Xinjiang Medical University, Urumqi, 830011, China. 
      690579893@qq.com.
FAU - Lei, Fang
AU  - Lei F
AD  - College of pharmacy, Xinjiang Medical University, Urumqi, 830011, China.
FAU - Yupeng, Zhang
AU  - Yupeng Z
AD  - College of pharmacy, Xinjiang Medical University, Urumqi, 830011, China.
FAU - Wenhui, Shi
AU  - Wenhui S
AD  - Key Laboratory of Special Environmental Medicine of Xinjiang, General Hospital of 
      Xinjiang Military Region of PLA, Urumqi, 830000, China.
FAU - Aikemu, Ainiwaer
AU  - Aikemu A
AD  - College of pharmacy, Xinjiang Medical University, Urumqi, 830011, China.
FAU - Maimaitiyiming, Dilinuer
AU  - Maimaitiyiming D
AD  - Heart Center, The First Affiliated Hospital of Xinjiang Medical University, 
      Urumqi, 830054, China. 13999235355@163.com.
LA  - eng
GR  - No. 2021D01C289/the Natural Science Foundation of Xinjiang Uygur Autonomous 
      Region/
PT  - Journal Article
DEP - 20230506
PL  - England
TA  - BMC Complement Med Ther
JT  - BMC complementary medicine and therapies
JID - 101761232
RN  - 0 (bcl-2-Associated X Protein)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Reactive Oxygen Species)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - 0 (Tannins)
RN  - Pulmonary edema of mountaineers
SB  - IM
MH  - Animals
MH  - Rats
MH  - Altitude
MH  - *Altitude Sickness
MH  - bcl-2-Associated X Protein
MH  - Endothelial Cells/metabolism
MH  - Hydrogen Peroxide/adverse effects
MH  - *Hypertension, Pulmonary/drug therapy
MH  - NF-E2-Related Factor 2/metabolism
MH  - Proto-Oncogene Proteins c-bcl-2/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction
MH  - Superoxide Dismutase/metabolism
MH  - Tannins/pharmacology
MH  - *Terminalia
PMC - PMC10163731
OTO - NOTNLM
OT  - HO-1
OT  - High-altitude pulmonary hypertension
OT  - Nrf2
OT  - Tannins
OT  - Terminalia bellirica (Gaertn.) Roxb
COIS- The authors declare that they have no competing interests.
EDAT- 2023/05/07 00:42
MHDA- 2023/05/08 06:42
PMCR- 2023/05/06
CRDT- 2023/05/06 23:14
PHST- 2023/02/11 00:00 [received]
PHST- 2023/04/27 00:00 [accepted]
PHST- 2023/05/08 06:42 [medline]
PHST- 2023/05/07 00:42 [pubmed]
PHST- 2023/05/06 23:14 [entrez]
PHST- 2023/05/06 00:00 [pmc-release]
AID - 10.1186/s12906-023-03981-2 [pii]
AID - 3981 [pii]
AID - 10.1186/s12906-023-03981-2 [doi]
PST - epublish
SO  - BMC Complement Med Ther. 2023 May 6;23(1):150. doi: 10.1186/s12906-023-03981-2.