PMID- 37150230
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20231116
IS  - 1089-8646 (Electronic)
IS  - 0888-7543 (Linking)
VI  - 115
IP  - 4
DP  - 2023 Jul
TI  - SCARA5 in bone marrow stromal cell-derived exosomes inhibits colorectal cancer 
      progression by inactivating the PI3K/Akt pathway.
PG  - 110636
LID - S0888-7543(23)00080-0 [pii]
LID - 10.1016/j.ygeno.2023.110636 [doi]
AB  - Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer worldwide. 
      Bone marrow stromal cells (BMSCs) play an essential role in tumor development by 
      secreting exosomes. Scavenger receptor class A member 5 (SCARA5) is a newly 
      identified tumor suppressor. This study aimed to investigate the effects of 
      BMSCs-derived exosomes (BMSCs-Exos) on CRC development and to explore their 
      regulatory mechanisms. BMSCs-Exos showed an oval-shaped, bilayer membrane 
      structure. BMSCs-Exos inhibited growth and motility of CRC cells, while 
      BMSCs-Exos with SCARA5 knockdown significantly promoted cell proliferation and 
      movement. Exosomal SCARA5 also effectively suppressed colorectal tumor growth in 
      mouse xenografts. Further analysis revealed that exosomal SCARA5 inhibited the 
      phosphorylation of protein kinase B and phosphoinositide 3-kinase in both CRC 
      cells and tumors. In conclusion, SCARA5 in BMSCs-Exos inhibited CRC progression 
      by inactivating PI3K/Akt, thus suggesting the potential clinical application of 
      SCARA5-containing BMSCs-Exos for CRC treatment.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Fang, Yu
AU  - Fang Y
AD  - Department of Phase I Oncology Clinical Trials Center, Harbin Medical University 
      Cancer Hospital, Harbin Medical University, Harbin 150000, Heilongjiang Province, 
      PR China.
FAU - Wu, Feng
AU  - Wu F
AD  - Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical 
      University, Harbin 150000, Heilongjiang Province, PR China.
FAU - Shang, Guoyin
AU  - Shang G
AD  - Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical 
      University, Harbin 150000, Heilongjiang Province, PR China.
FAU - Yin, Changqing
AU  - Yin C
AD  - Department of Gastroenterology, The Second Affiliated Hospital of Dalian Medical 
      University, Dalian 116023, Liaoning Province,PR China. Electronic address: 
      yinchangqing2022@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230505
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - 0 (MicroRNAs)
RN  - 0 (SCARA5 protein, human)
RN  - 0 (Scavenger Receptors, Class A)
RN  - 0 (SCARA5 protein, mouse)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - *Exosomes/metabolism
MH  - *Colorectal Neoplasms/metabolism
MH  - Cell Proliferation
MH  - *Mesenchymal Stem Cells/metabolism
MH  - *MicroRNAs/metabolism
MH  - Scavenger Receptors, Class A/metabolism
OTO - NOTNLM
OT  - Bone marrow stromal cell
OT  - Colorectal cancer
OT  - Exosomes
OT  - PI3K/Akt
OT  - SCARA5
COIS- Declaration of Competing Interest The authors declare that they have no conflict 
      of interest.
EDAT- 2023/05/08 00:41
MHDA- 2023/06/19 13:08
CRDT- 2023/05/07 19:23
PHST- 2022/12/28 00:00 [received]
PHST- 2023/04/21 00:00 [revised]
PHST- 2023/05/03 00:00 [accepted]
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/05/08 00:41 [pubmed]
PHST- 2023/05/07 19:23 [entrez]
AID - S0888-7543(23)00080-0 [pii]
AID - 10.1016/j.ygeno.2023.110636 [doi]
PST - ppublish
SO  - Genomics. 2023 Jul;115(4):110636. doi: 10.1016/j.ygeno.2023.110636. Epub 2023 May 
      5.