PMID- 37150661
OWN - NLM
STAT- MEDLINE
DCOM- 20230607
LR  - 20230607
IS  - 1876-861X (Electronic)
IS  - 1876-861X (Linking)
VI  - 17
IP  - 3
DP  - 2023 May-Jun
TI  - Systemic arterial calcium burden in patients with chronic limb-threatening 
      ischemia.
PG  - 192-200
LID - S1934-5925(23)00088-6 [pii]
LID - 10.1016/j.jcct.2023.03.003 [doi]
AB  - INTRODUCTION: 5-year mortality of chronic limb-threatening ischemia (CLTI) is 
      50-60% and coronary artery disease (CAD) is the main cause of death of CLTI 
      patients, followed by stroke. The aim of this study is to quantify and qualify 
      the calcium load in different arterial territories in patients with CLTI. 
      METHODS: Prospectively, 60 patients with CLTI were included and received a 
      full-body CT scan. 6 patients were excluded. Different arterial territories (the 
      peripheral lower extremity arteries, coronary arteries, extracranial and 
      intracranial carotid arteries, thoracic and abdominal aorta) were analyzed. 
      Analysis and interrelations of both quantitative and semi-quantitative CT 
      measurements was performed. RESULTS: Mean age was 72 years (range 47-95; SD 
      11.4). Almost all CLTI patients had calcified arterial beds (femoropopliteal 
      100%, crural 98.1%, coronary 100%, carotid bifurcation 96.2%, internal carotid 
      artery 98.1%, thoracic aorta 96.2%, abdominal aorta 92.3%). Nearly all arterial 
      territories had severe calcifications. 57% had a very high coronary Agatston 
      score (>1000), and 35% extremely high (>2000). Calcifications in the lower 
      extremity were significantly correlated to CAC score, carotid artery bifurcation 
      calcification score, and to a lesser extent correlated to annular calcifications 
      in the aorta. Very high and extremely high total CAC scores were strongly 
      correlated with severe lower extremity arterial calcifications and severe carotid 
      and intracranial internal carotid artery, thoracic and abdominal aorta 
      calcifications in patients with CLTI patients. CONCLUSIONS: In CLTI patients 
      nearly all arterial territories are severely calcified, suggesting that systemic 
      calcification plays an important role in the poor outcome of this disease.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Konijn, L C D
AU  - Konijn LCD
AD  - Haga Hospital, Department of Diagnostic and Interventional Radiology, the 
      Netherlands; University Medical Center Utrecht and Utrecht University, Department 
      of Radiology and Nuclear Medicine, the Netherlands. Electronic address: 
      l.c.d.konijn@amsterdamumc.nl.
FAU - Mali, W P T M
AU  - Mali WPTM
AD  - University Medical Center Utrecht and Utrecht University, Department of Radiology 
      and Nuclear Medicine, the Netherlands. Electronic address: w.mali@umcutrecht.nl.
FAU - van Overhagen, H
AU  - van Overhagen H
AD  - Haga Hospital, Department of Diagnostic and Interventional Radiology, the 
      Netherlands. Electronic address: h.voverhagen@hagaziekenhuis.nl.
FAU - Takx, R A P
AU  - Takx RAP
AD  - University Medical Center Utrecht and Utrecht University, Department of Radiology 
      and Nuclear Medicine, the Netherlands. Electronic address: 
      r.a.p.takx@umcutrecht.nl.
FAU - Veger, H T C
AU  - Veger HTC
AD  - Haga Hospital, Department of Vascular Surgery, the Netherlands. Electronic 
      address: h.veger@hagaziekenhuis.nl.
FAU - de Jong, P A
AU  - de Jong PA
AD  - University Medical Center Utrecht and Utrecht University, Department of Radiology 
      and Nuclear Medicine, the Netherlands. Electronic address: 
      p.dejong-8@umcutrecht.nl.
LA  - eng
PT  - Journal Article
DEP - 20230505
PL  - United States
TA  - J Cardiovasc Comput Tomogr
JT  - Journal of cardiovascular computed tomography
JID - 101308347
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Limb-Threatening Ischemia
MH  - Calcium
MH  - Predictive Value of Tests
MH  - Lower Extremity/blood supply
MH  - Femoral Artery
MH  - *Calcinosis
MH  - *Carotid Artery Diseases
MH  - *Peripheral Arterial Disease/diagnostic imaging
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Retrospective Studies
MH  - Chronic Disease
OTO - NOTNLM
OT  - Arteriosclerosis
OT  - Atherosclerosis
OT  - Chronic limb-threatening ischemia
OT  - Peripheral arterial disease
COIS- Declaration of competing interests All authors declare that they have received no 
      grants, contracts, other forms of financial supports or relationships with the 
      industry relevant to this paper.
EDAT- 2023/05/08 00:41
MHDA- 2023/06/07 06:42
CRDT- 2023/05/07 21:59
PHST- 2022/08/14 00:00 [received]
PHST- 2023/02/12 00:00 [revised]
PHST- 2023/03/11 00:00 [accepted]
PHST- 2023/06/07 06:42 [medline]
PHST- 2023/05/08 00:41 [pubmed]
PHST- 2023/05/07 21:59 [entrez]
AID - S1934-5925(23)00088-6 [pii]
AID - 10.1016/j.jcct.2023.03.003 [doi]
PST - ppublish
SO  - J Cardiovasc Comput Tomogr. 2023 May-Jun;17(3):192-200. doi: 
      10.1016/j.jcct.2023.03.003. Epub 2023 May 5.