PMID- 37152563
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230509
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 13
IP  - 20
DP  - 2023 May 2
TI  - Magnetic dummy template molecularly imprinted particles functionalized with 
      dendritic nanoclusters for selective enrichment and determination of 
      4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in tobacco products.
PG  - 13824-13833
LID - 10.1039/d3ra00610g [doi]
AB  - The compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), one of the 
      tobacco specific nitrosamines (TSNAs), is widely recognized as a major carcinogen 
      found in tobacco products, environmental tobacco smoke and wastewater. Thus, a 
      selective enrichment and sensitive detection method for monitoring the risk of 
      NNK exposure is highly desirable. In this study, a magnetic molecularly imprinted 
      polymer (MMIP) functionalized with dendritic nanoclusters was synthesized to 
      selectively recognize NNK via the dummy template imprinting strategy, aiming to 
      avoid residual template leakage and increase the imprinting efficiency. The 
      nanocomposites were characterized by scanning electron microscopy (SEM), 
      transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), 
      X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, as well 
      as vibrating sample magnetometry (VSM) and nitrogen adsorption/desorption 
      analysis. The resulting MMIPs exhibited high adsorption capacity, fast binding 
      kinetics and good selectivity for trace amounts of NNK. A rapid, low cost and 
      efficient method for detecting NNK in tobacco products was established using 
      magnetic dispersive solid-phase extraction coupled with HPLC-DAD with a good 
      linear range of 0.1-250 mug mL(-1). The limit of detection (LOD) and limit of 
      quantification (LOQ) of NNK were 13.5 and 25.0 ng mL(-1), respectively. The 
      average recoveries were 87.8-97.3% with RSDs lower than 3%. The results confirmed 
      that the MMIPs could be used as an excellent selective adsorbent for NNK, with 
      potential applications in the pretreatment of tobacco products.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Zheng, Yani
AU  - Zheng Y
AD  - School of Pharmacy, Nanjing Medical University Nanjing Jiangsu 211166 China 
      junlihong@njmu.edu.cn +86 25 86868476 +86 25 86868476.
FAU - Dai, Yin
AU  - Dai Y
AD  - School of Pharmacy, Nanjing Medical University Nanjing Jiangsu 211166 China 
      junlihong@njmu.edu.cn +86 25 86868476 +86 25 86868476.
FAU - Hong, Junqiang
AU  - Hong J
AD  - Department of Radiotherapy, Fujian Medical University Affiliated Xiamen Humanity 
      Hospital Xiamen Fujian 361000 China.
FAU - Fan, Huizhu
AU  - Fan H
AD  - School of Pharmacy, Nanjing Medical University Nanjing Jiangsu 211166 China 
      junlihong@njmu.edu.cn +86 25 86868476 +86 25 86868476.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - School of Pharmacy, Nanjing Medical University Nanjing Jiangsu 211166 China 
      junlihong@njmu.edu.cn +86 25 86868476 +86 25 86868476.
AD  - Anhui Province Key Laboratory of Research & Development of Chinese Medicine Hefei 
      230012 China.
FAU - Jiang, Wei
AU  - Jiang W
AD  - Yunnan Key Laboratory of Tobacco Chemistry, Research and Development Center of 
      China Tobacco Yunnan Industrial Co. Ltd Kunming Yunnan 650231 China.
FAU - Xu, Wei
AU  - Xu W
AD  - School of Pharmacy, Nanjing Medical University Nanjing Jiangsu 211166 China 
      junlihong@njmu.edu.cn +86 25 86868476 +86 25 86868476.
FAU - Fei, Jianwen
AU  - Fei J
AD  - School of Pharmacy, Nanjing Medical University Nanjing Jiangsu 211166 China 
      junlihong@njmu.edu.cn +86 25 86868476 +86 25 86868476.
FAU - Hong, Junli
AU  - Hong J
AUID- ORCID: 0009-0005-7384-2692
AD  - School of Pharmacy, Nanjing Medical University Nanjing Jiangsu 211166 China 
      junlihong@njmu.edu.cn +86 25 86868476 +86 25 86868476.
LA  - eng
PT  - Journal Article
DEP - 20230505
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC10160923
COIS- There are no conflicts to declare.
EDAT- 2023/05/08 06:41
MHDA- 2023/05/08 06:42
PMCR- 2023/05/05
CRDT- 2023/05/08 04:04
PHST- 2023/01/29 00:00 [received]
PHST- 2023/04/18 00:00 [accepted]
PHST- 2023/05/08 06:42 [medline]
PHST- 2023/05/08 06:41 [pubmed]
PHST- 2023/05/08 04:04 [entrez]
PHST- 2023/05/05 00:00 [pmc-release]
AID - d3ra00610g [pii]
AID - 10.1039/d3ra00610g [doi]
PST - epublish
SO  - RSC Adv. 2023 May 5;13(20):13824-13833. doi: 10.1039/d3ra00610g. eCollection 2023 
      May 2.