PMID- 37152580
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231102
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 13
IP  - 20
DP  - 2023 May 2
TI  - Synthesis and identification of new sacubitril derivatives as lead compounds for 
      antibacterial, antifungal and antitubercular (TB) activities against dormant 
      tuberculosis.
PG  - 13540-13546
LID - 10.1039/d3ra00713h [doi]
AB  - We identified twenty-two new sacubitril derivatives (5a-v) as lead compounds for 
      various biologically active targets. These compounds were synthesized by reacting 
      an intermediate compound 
      (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(amino)-2-methylpentanoic acid ethyl ester 
      hydrochloride with respective carboxylic acid (RCOOH). The molecular structures 
      of all the newly synthesized compounds were determined by (1)H and (13)C NMR, ESI 
      mass spectrometry, FTIR spectroscopy, and CHN analysis. Moreover, compound 5n was 
      characterized by a single-crystal X-ray diffraction (SXRD) study to confirm the 
      structure obtained from spectral data. All these compounds were screened for 
      various biological functions such as antifungal, antibacterial, and anti-TB 
      activities. Among these twenty-two compounds (5a-v), some exhibited good to 
      moderate anti-bacterial properties. Similarly, some compounds showed moderate 
      anti-TB and antifungal activities. In addition, the anti-TB activity of compound 
      5q was estimated against M. tuberculosis in a nutrient starvation model (NSM). 
      Similarly, toxicity was examined against RAW 264.7 cells. These biological 
      activity studies were also correlated with molecular docking studies.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Bhargavi, Dodda
AU  - Bhargavi D
AD  - New Generation Materials Lab (NGML), Department of Chemistry, School of Applied 
      Science and Humanities, Vignan's Foundation for Science Technology and Research 
      (VFSTR) (Deemed to be University) Vadlamudi Guntur-522 213 Andhra Pradesh India 
      drkpr_sh@vignan.ac.in kprao2005@gmail.com.
FAU - Konduri, Srihari
AU  - Konduri S
AD  - Skaggs School of Pharmacy and Pharmaceutical Sciences UC San Diego, 9500 Gilman 
      Drive La Jolla CA 92093 USA.
FAU - Prashanth, Jyothi
AU  - Prashanth J
AUID- ORCID: 0000-0002-0276-8502
AD  - Department of Physics, Kakatiya University Warangal 506009 Telangana India.
FAU - Pulipati, Sowjanya
AU  - Pulipati S
AD  - Department of Pharmaceutical Biotechnology, Vignan Pharmacy College Vadlamudi 
      Guntur-522213 Andhra Pradesh India.
FAU - Praneeth, K K
AU  - Praneeth KK
AUID- ORCID: 0000-0003-1766-8763
AD  - Somaiya Vidyavihar University Vidyavihar Mumbai-400077 Maharashtra India.
FAU - Sireesha, Malladi
AU  - Sireesha M
AD  - New Generation Materials Lab (NGML), Department of Chemistry, School of Applied 
      Science and Humanities, Vignan's Foundation for Science Technology and Research 
      (VFSTR) (Deemed to be University) Vadlamudi Guntur-522 213 Andhra Pradesh India 
      drkpr_sh@vignan.ac.in kprao2005@gmail.com.
FAU - Rao, Koya Prabhakara
AU  - Rao KP
AUID- ORCID: 0000-0001-6077-5746
AD  - New Generation Materials Lab (NGML), Department of Chemistry, School of Applied 
      Science and Humanities, Vignan's Foundation for Science Technology and Research 
      (VFSTR) (Deemed to be University) Vadlamudi Guntur-522 213 Andhra Pradesh India 
      drkpr_sh@vignan.ac.in kprao2005@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230503
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC10155492
COIS- There are no conflicts to declare.
EDAT- 2023/05/08 06:41
MHDA- 2023/05/08 06:42
PMCR- 2023/05/03
CRDT- 2023/05/08 04:04
PHST- 2023/02/02 00:00 [received]
PHST- 2023/04/13 00:00 [accepted]
PHST- 2023/05/08 06:42 [medline]
PHST- 2023/05/08 06:41 [pubmed]
PHST- 2023/05/08 04:04 [entrez]
PHST- 2023/05/03 00:00 [pmc-release]
AID - d3ra00713h [pii]
AID - 10.1039/d3ra00713h [doi]
PST - epublish
SO  - RSC Adv. 2023 May 3;13(20):13540-13546. doi: 10.1039/d3ra00713h. eCollection 2023 
      May 2.