PMID- 37152992
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230605
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 14
DP  - 2023
TI  - Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing.
PG  - 1144945
LID - 10.3389/fgene.2023.1144945 [doi]
LID - 1144945
AB  - Background: The aim of this study was to investigate the underlying mechanisms of 
      adenoid cystic carcinoma (ACC) at the transcriptome level. Materials and methods: 
      We obtained paired tumor and normal salivary gland tissues from 15 ACC patients, 
      which were prepared for RNA sequencing. Results: Gene enrichment analysis 
      revealed that the upregulated pathways were mainly involved in axonogenesis, and 
      the downregulated pathways were mainly related to leukocyte migration, the 
      adaptive immune response, lymphocyte-mediated immunity, and the humoral immune 
      response. T-cells, B-cells and NK cells showed low infiltration in ACC tissues. 
      In addition to the gene fusions MYB-NFIB and MYBL1-NFIB, a new gene fusion, 
      TVP23C-CDRT4, was also detected in 3 ACC tissues. PRAME was significantly 
      upregulated in ACC tissues, while antigen-presenting human leukocyte antigen 
      (HLA) genes were downregulated. Conclusion: We found a new gene fusion, 
      TVP23C-CDRT4, that was highly expressed in ACC. PRAME may be an attractive target 
      for ACC immunotherapy.
CI  - Copyright (c) 2023 Tang, An, Gu, Yi, Hu, Wu and Zhang.
FAU - Tang, Yu-Fang
AU  - Tang YF
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - National Center of Stomatology and National Clinical Research Center for Oral 
      Diseases, Beijing, China.
AD  - Central Laboratory, Peking University School and Hospital of Stomatology, 
      Beijing, China.
AD  - Department of Stomatology, Xinqiao Hospital (the Second Affiliated Hospital), 
      Army Medical University, Chongqing, China.
FAU - An, Pu-Gen
AU  - An PG
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - National Center of Stomatology and National Clinical Research Center for Oral 
      Diseases, Beijing, China.
AD  - Central Laboratory, Peking University School and Hospital of Stomatology, 
      Beijing, China.
FAU - Gu, Bao-Xin
AU  - Gu BX
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - National Center of Stomatology and National Clinical Research Center for Oral 
      Diseases, Beijing, China.
AD  - Central Laboratory, Peking University School and Hospital of Stomatology, 
      Beijing, China.
FAU - Yi, Shu
AU  - Yi S
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - National Center of Stomatology and National Clinical Research Center for Oral 
      Diseases, Beijing, China.
AD  - Central Laboratory, Peking University School and Hospital of Stomatology, 
      Beijing, China.
FAU - Hu, Xiao
AU  - Hu X
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - National Center of Stomatology and National Clinical Research Center for Oral 
      Diseases, Beijing, China.
AD  - Central Laboratory, Peking University School and Hospital of Stomatology, 
      Beijing, China.
FAU - Wu, Wen-Jie
AU  - Wu WJ
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - National Center of Stomatology and National Clinical Research Center for Oral 
      Diseases, Beijing, China.
AD  - Central Laboratory, Peking University School and Hospital of Stomatology, 
      Beijing, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - National Center of Stomatology and National Clinical Research Center for Oral 
      Diseases, Beijing, China.
AD  - Central Laboratory, Peking University School and Hospital of Stomatology, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20230421
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC10160386
OTO - NOTNLM
OT  - RNA sequencing
OT  - adenoid cystic carcinoma (ACC)
OT  - cancer germline antigens
OT  - gene fusions
OT  - mRNA
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/05/08 06:41
MHDA- 2023/05/08 06:42
PMCR- 2023/04/21
CRDT- 2023/05/08 04:10
PHST- 2023/01/15 00:00 [received]
PHST- 2023/04/10 00:00 [accepted]
PHST- 2023/05/08 06:42 [medline]
PHST- 2023/05/08 06:41 [pubmed]
PHST- 2023/05/08 04:10 [entrez]
PHST- 2023/04/21 00:00 [pmc-release]
AID - 1144945 [pii]
AID - 10.3389/fgene.2023.1144945 [doi]
PST - epublish
SO  - Front Genet. 2023 Apr 21;14:1144945. doi: 10.3389/fgene.2023.1144945. eCollection 
      2023.