PMID- 37153295
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230509
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 4
DP  - 2023 Apr
TI  - Xp11.2 Translocation Renal Cell Carcinoma: A Rare Renal Cell Carcinoma.
PG  - e37072
LID - 10.7759/cureus.37072 [doi]
LID - e37072
AB  - Translocation-associated renal cell carcinoma (TRCC) is a group of 
      under-recognized malignant renal neoplasms owing to the unavailability of 
      ancillary diagnostic tools and considering the fact that these tumors may 
      histomorphologically mimic a heterogeneous group of neoplasms ranging from benign 
      to malignant ones. Xp11.2 translocation-associated renal cell carcinoma is a 
      disease of the young with a relatively less known prognosis owing to the rarity 
      of such reported neoplasms. The histological appearance of bulbous tumor cells 
      with abundant, vacuolated cytoplasm and the presence of psammomatoid bodies are 
      clues to the diagnosis but are not entirely specific. The immunohistochemistry 
      (IHC) finding of transcription factor E3 (TFE3) positivity is an important 
      pointer, but the demonstration of Xp11.2 translocation by fluorescence in situ 
      hybridization (FISH) serves as the confirmatory test. In our case report, we 
      highlight the fact that a combined approach involving light microscopy, 
      immunohistochemistry, and fluorescence in situ hybridization is the key to its 
      diagnosis.
CI  - Copyright (c) 2023, Kalita et al.
FAU - Kalita, Pranjal
AU  - Kalita P
AD  - Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical 
      Sciences (NEIGRIHMS), Shillong, IND.
FAU - Dey, Biswajit
AU  - Dey B
AD  - Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical 
      Sciences (NEIGRIHMS), Shillong, IND.
FAU - Saurabh, Animesh
AU  - Saurabh A
AD  - Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical 
      Sciences (NEIGRIHMS), Shillong, IND.
FAU - Chishti, Sheikh F
AU  - Chishti SF
AD  - Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical 
      Sciences (NEIGRIHMS), Shillong, IND.
LA  - eng
PT  - Case Reports
DEP - 20230403
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10155824
OTO - NOTNLM
OT  - clear cell renal cell carcinoma
OT  - immunohistochemistry(ihc)
OT  - tfe3
OT  - translocation-associated renal cell carcinoma
OT  - xp11.2
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/05/08 06:41
MHDA- 2023/05/08 06:42
PMCR- 2023/04/03
CRDT- 2023/05/08 04:13
PHST- 2023/04/03 00:00 [accepted]
PHST- 2023/05/08 06:42 [medline]
PHST- 2023/05/08 06:41 [pubmed]
PHST- 2023/05/08 04:13 [entrez]
PHST- 2023/04/03 00:00 [pmc-release]
AID - 10.7759/cureus.37072 [doi]
PST - epublish
SO  - Cureus. 2023 Apr 3;15(4):e37072. doi: 10.7759/cureus.37072. eCollection 2023 Apr.