PMID- 37154141
OWN - NLM
STAT- MEDLINE
DCOM- 20230510
LR  - 20230510
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 45
IP  - 1
DP  - 2023 Dec 31
TI  - Folic acid enhances the cardiovascular protective effect of amlodipine in renal 
      hypertensive rats with elevated homocysteine.
PG  - 2205058
LID - 10.1080/10641963.2023.2205058 [doi]
AB  - OBJECTIVES: To investigate the actions of amlodipine-folic acid (amlodipine-FA) 
      preparation on hypertension and cardiovascular in renal hypertensive rats with 
      hyperhomocysteinemia (HHcy), so as to provide experimental basis for clinical 
      research of amlodipine folic acid tablets. METHODS: Rats model of renal 
      hypertension with HHcy were established. The rats were randomly divided into 
      groups of model, amlodipine, folic acid (FA) and amlodipine-FA of various 
      dosages. Normal rats were used as normal control group. Blood pressure, Hcy as 
      well as plasma NO, ET-1 and hemodynamics were assayed. Histological alterations 
      of heart and abdominal aorta were also examined. RESULTS: Compared with the 
      normal group, blood pressure, plasma Hcy, and NO of the rats in model group were 
      significantly increased, while the plasma ET-1 was decreased. Compared with the 
      normal group, the animals in the model group had reduced cardiac function, 
      thickened wall of the aorta and narrowed lumen. In FA group and amlodipine group, 
      the rat plasma NO was increased while ET-1 was decreased, the protective effect 
      of amlodipine-FA group on endothelial cells was further enhanced. In amlodipine 
      group, the rat hemodynamics (LVSP, LVEDP and +/-dp/dt(max), et al.) and vascular 
      damage were significantly reduced, while in amlodipine-FA group, the heart 
      function were further improved, and myocardial and vascular hypertrophy were 
      significantly reduced. CONCLUSIONS: As compared to amlodipine alone, amlodipine 
      -FA can lower both blood pressure and plasma Hcy, significantly enhancing 
      vascular endothelial function to protect the heart and blood vessel in renal 
      hypertensive rats with HHcy.
FAU - Li, Li
AU  - Li L
AD  - College of Integrative Medicine, Anhui University of Chinese Medicine, Hefei, 
      China.
FAU - Tong, Xiaohui
AU  - Tong X
AD  - College of Integrative Medicine, Anhui University of Chinese Medicine, Hefei, 
      China.
FAU - Ma, Zebin
AU  - Ma Z
AD  - College of Integrative Medicine, Anhui University of Chinese Medicine, Hefei, 
      China.
FAU - Lv, Lei
AU  - Lv L
AD  - College of Integrative Medicine, Anhui University of Chinese Medicine, Hefei, 
      China.
FAU - Liu, Haipeng
AU  - Liu H
AD  - Institute of Pediatrics, Anhui Provincial Children's Hospital, Hefei, China.
FAU - Chen, Guang Liang
AU  - Chen GL
AD  - College of Integrative Medicine, Anhui University of Chinese Medicine, Hefei, 
      China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 935E97BOY8 (Folic Acid)
RN  - 1J444QC288 (Amlodipine)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Folic Acid/pharmacology
MH  - Amlodipine/pharmacology
MH  - Endothelial Cells
MH  - *Hypertension/complications/drug therapy
MH  - Kidney
MH  - Homocysteine
MH  - *Hyperhomocysteinemia/complications/drug therapy
OTO - NOTNLM
OT  - Amlodipine
OT  - cardiovascular protection
OT  - folic acid
OT  - homocysteine
OT  - hypertension
EDAT- 2023/05/08 06:42
MHDA- 2023/05/10 06:42
CRDT- 2023/05/08 05:54
PHST- 2023/05/10 06:42 [medline]
PHST- 2023/05/08 06:42 [pubmed]
PHST- 2023/05/08 05:54 [entrez]
AID - 10.1080/10641963.2023.2205058 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2023 Dec 31;45(1):2205058. doi: 
      10.1080/10641963.2023.2205058.