PMID- 37154220
OWN - NLM
STAT- MEDLINE
DCOM- 20230601
LR  - 20230727
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 37
IP  - 3
DP  - 2023 May-Jun
TI  - Escherichia coli-associated follicular cystitis in dogs: Clinical and pathologic 
      characterization.
PG  - 1059-1066
LID - 10.1111/jvim.16719 [doi]
AB  - BACKGROUND: Follicular cystitis is an uncommon inflammatory change in the urinary 
      bladder wall characterized by the formation of tertiary lymphoid structures 
      (TLSs) in the submucosa. OBJECTIVES: To characterize clinical and pathologic 
      features of follicular cystitis in dogs and to explore in situ distribution and 
      possible role of Escherichia coli as an associated cause. ANIMALS: Eight dogs 
      diagnosed with follicular cystitis and 2 control dogs. METHODS: Retrospective 
      descriptive study. Dogs diagnosed with follicular cystitis (macroscopic 
      follicular lesions in the urinary bladder mucosa and histopathologic detection of 
      TLSs in bladder wall biopsies) were identified from medical records. Paraffin 
      embedded bladder wall biopsies were subject to in situ hybridization for E. coli 
      16SrRNA identification. RESULTS: Follicular cystitis was diagnosed in large breed 
      (median weight 24.9 kg, interquartile range [IQR] 18.8-35.4 kg) female dogs with 
      a history of chronic recurrent urinary tract infections (UTIs; median duration of 
      clinical signs 7 months, IQR 3-17 months; median number of previous UTIs 5, IQR 
      4-6). Positive E. coli 16SrRNA signal was detected within developing, immature 
      and mature TLSs in 7/8 dogs, through submucosal stroma in 8/8 dogs and within the 
      urothelium in 3/8 dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: Chronic inflammation 
      associated with an intramural E. coli infection in the urinary bladder wall 
      represents a possible triggering factor for the development of follicular 
      cystitis.
CI  - (c) 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
FAU - Viitanen, Sanna J
AU  - Viitanen SJ
AUID- ORCID: 0000-0002-1208-5799
AD  - Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
FAU - Tuomisto, Laura
AU  - Tuomisto L
AD  - Department of Veterinary Biosciences, Pathology and Parasitology Unit, Faculty of 
      Veterinary Medicine, University of Helsinki, Helsinki, Finland.
FAU - Salonen, Nina
AU  - Salonen N
AD  - Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
FAU - Eskola, Katariina
AU  - Eskola K
AD  - Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
FAU - Kegler, Kristel
AU  - Kegler K
AD  - Department of Veterinary Biosciences, Pathology and Parasitology Unit, Faculty of 
      Veterinary Medicine, University of Helsinki, Helsinki, Finland.
LA  - eng
GR  - Suomen Elainlaaketieteen Saatio/
PT  - Journal Article
DEP - 20230508
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
SB  - IM
EIN - J Vet Intern Med. 2023 Sep-Oct;37(5):1944. PMID: 37497786
MH  - Dogs
MH  - Female
MH  - Animals
MH  - Escherichia coli
MH  - Retrospective Studies
MH  - *Cystitis/veterinary/pathology
MH  - Urinary Bladder/pathology
MH  - *Urinary Tract Infections/veterinary
MH  - *Escherichia coli Infections/complications/veterinary
MH  - *Dog Diseases/diagnosis
PMC - PMC10229364
OTO - NOTNLM
OT  - canine
OT  - histopathology
OT  - in situ hybridization
OT  - urinary
COIS- Authors declare no conflict of interest.
EDAT- 2023/05/08 13:42
MHDA- 2023/06/01 06:42
PMCR- 2023/05/08
CRDT- 2023/05/08 06:42
PHST- 2022/10/24 00:00 [received]
PHST- 2023/04/07 00:00 [accepted]
PHST- 2023/06/01 06:42 [medline]
PHST- 2023/05/08 13:42 [pubmed]
PHST- 2023/05/08 06:42 [entrez]
PHST- 2023/05/08 00:00 [pmc-release]
AID - JVIM16719 [pii]
AID - 10.1111/jvim.16719 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2023 May-Jun;37(3):1059-1066. doi: 10.1111/jvim.16719. Epub 
      2023 May 8.