PMID- 37154520 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20230516 LR - 20230516 IS - 1520-6882 (Electronic) IS - 0003-2700 (Linking) VI - 95 IP - 19 DP - 2023 May 16 TI - Multifunctionalized Covalent Organic Frameworks for Broad-Spectrum Extraction and Ultrasensitive Analysis of Per- and Polyfluoroalkyl Substances. PG - 7770-7778 LID - 10.1021/acs.analchem.3c01137 [doi] AB - The contamination of surface and ground water by per- and polyfluoroalkyl substances (PFASs) has become a growing concern, and the structural diversity of PFASs is the major challenge for their ubiquitous applications. Strategies for monitoring coexistent anionic, cationic, and zwitterionic PFASs even at trace levels in aquatic environments are urgently demanded for effective pollution control. Herein, novel amide group and perfluoroalkyl chain-functionalized covalent organic frameworks (COFs) named COF-NH-CO-F9 are successfully synthesized and used for highly efficient extraction of broad-spectrum PFASs, attributing to their unique structure and the multifunctional groups. Under the optimal conditions, a simple and high-sensitivity method is established to quantify 14 PFASs including anionic, cationic, and zwitterionic species by coupling solid-phase microextraction (SPME) with ultrahigh-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-MS/MS) for the first time. The established method displays high enrichment factors (EFs) of 66-160, ultrahigh sensitivity with low limits of detection (LODs) of 0.0035-0.18 ng L(-1), a wide linearity of 0.1-2000 ng L(-1) with correlation coefficient (R(2)) >/=0.9925, and satisfactory precision with relative standard deviations (RSDs)