PMID- 37154966
OWN - NLM
STAT- MEDLINE
DCOM- 20230510
LR  - 20230510
IS  - 1432-072X (Electronic)
IS  - 0302-8933 (Linking)
VI  - 205
IP  - 6
DP  - 2023 May 8
TI  - Impact of the first-line antiretroviral therapy on soluble markers of 
      inflammation in cohort of human immunodeficiency virus type 1 in Moroccan 
      patients: a prospective study.
PG  - 223
LID - 10.1007/s00203-023-03574-0 [doi]
AB  - Chronic inflammation and immune activation are a hallmark of HIV-1 infection. In 
      this study, we assessed inflammation biomarkers in a cohort of people living with 
      HIV-1 (PLWH) before and after long-term suppressive combined antiretroviral 
      therapy (cART). A single-center prospective cohort study was conducted to assess 
      inflammatory biomarkers in 86 cART-naive PLWH and after receiving suppressive 
      cART and 50 uninfected controls. Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 
      (IL-6), and soluble CD14 (sCD14) were measured using enzyme-linked immunosorbent 
      assay (ELISA). No significant difference was found in IL-6 levels between 
      cART-naive PLWH and controls (p = 0.753). In contrast, TNF-alpha level showed a 
      significant difference between cART naive-PLWH and controls (p = 0.019). 
      Interestingly, IL-6 and TNF-alpha levels were significantly decreased in PLWH after 
      cART (p < 0.0001). The sCD14 showed no significant difference between cART-naive 
      patients and controls (p = 0.839) and similar levels were observed in pre- and 
      post-treatment (p = 0.719). Our results highlight the critical importance of 
      early treatment to reduce inflammation and its consequences during HIV infection.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Haddaji, Asmaa
AU  - Haddaji A
AD  - Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place 
      Louis Pasteur, 20360, Casablanca, Morocco.
AD  - Laboratory of Virology, Oncology, Biosciences, Environment and New Energies, 
      Faculty of Sciences and Techniques of Mohammedia, Hassan II University of 
      Casablanca, Mohammedia, Morocco.
FAU - Ouladlahsen, Ahd
AU  - Ouladlahsen A
AD  - Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, 
      Morocco.
AD  - Service Des Maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco.
FAU - Lkhider, Mustapha
AU  - Lkhider M
AD  - Laboratory of Virology, Oncology, Biosciences, Environment and New Energies, 
      Faculty of Sciences and Techniques of Mohammedia, Hassan II University of 
      Casablanca, Mohammedia, Morocco.
FAU - Bensghir, Rajaa
AU  - Bensghir R
AD  - Service Des Maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco.
FAU - Jebbar, Sanaa
AU  - Jebbar S
AD  - Service Des Maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco.
FAU - Hilmi, Soufiane
AU  - Hilmi S
AD  - Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place 
      Louis Pasteur, 20360, Casablanca, Morocco.
FAU - Abbadi, Islam
AU  - Abbadi I
AD  - Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place 
      Louis Pasteur, 20360, Casablanca, Morocco.
AD  - Laboratory of Virology, Oncology, Biosciences, Environment and New Energies, 
      Faculty of Sciences and Techniques of Mohammedia, Hassan II University of 
      Casablanca, Mohammedia, Morocco.
FAU - Sodqi, Mustapha
AU  - Sodqi M
AD  - Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, 
      Morocco.
AD  - Service Des Maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco.
FAU - Marih, Latifa
AU  - Marih L
AD  - Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, 
      Morocco.
AD  - Service Des Maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco.
FAU - Pineau, Pascal
AU  - Pineau P
AD  - Unite "Organisation Nucleaire et Oncogenese", INSERM U993, Institut Pasteur, 
      Paris, France.
FAU - El Filali, Kamal Marhoum
AU  - El Filali KM
AD  - Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, 
      Morocco.
AD  - Service Des Maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco.
FAU - Ezzikouri, Sayeh
AU  - Ezzikouri S
AD  - Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place 
      Louis Pasteur, 20360, Casablanca, Morocco. sayeh.ezzikouri@pasteur.ma.
LA  - eng
GR  - FASP2016/Association de Lutte Contre le Sida (ALCS)/
GR  - FASP2016/Association de Lutte Contre le Sida (ALCS)/
GR  - FASP2016/Association de Lutte Contre le Sida (ALCS)/
GR  - FASP2016/Association de Lutte Contre le Sida (ALCS)/
GR  - FASP2016/Association de Lutte Contre le Sida (ALCS)/
GR  - FASP2016/Association de Lutte Contre le Sida (ALCS)/
PT  - Journal Article
DEP - 20230508
PL  - Germany
TA  - Arch Microbiol
JT  - Archives of microbiology
JID - 0410427
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Prospective Studies
MH  - *HIV-1
MH  - *HIV Infections/drug therapy
MH  - Interleukin-6
MH  - Lipopolysaccharide Receptors
MH  - Tumor Necrosis Factor-alpha
MH  - Inflammation
MH  - Biomarkers
OTO - NOTNLM
OT  - AIDS
OT  - Antiretroviral therapy
OT  - HIV
OT  - IL-6
OT  - TNF-alpha
OT  - sCD14
EDAT- 2023/05/08 13:41
MHDA- 2023/05/10 06:42
CRDT- 2023/05/08 11:16
PHST- 2022/11/09 00:00 [received]
PHST- 2023/05/01 00:00 [accepted]
PHST- 2023/04/04 00:00 [revised]
PHST- 2023/05/10 06:42 [medline]
PHST- 2023/05/08 13:41 [pubmed]
PHST- 2023/05/08 11:16 [entrez]
AID - 10.1007/s00203-023-03574-0 [pii]
AID - 10.1007/s00203-023-03574-0 [doi]
PST - epublish
SO  - Arch Microbiol. 2023 May 8;205(6):223. doi: 10.1007/s00203-023-03574-0.