PMID- 37156051
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230531
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 665
DP  - 2023 Jul 12
TI  - Enhancement of antibacterial properties and biocompatibility of Ti(6)Al(4)V by 
      graphene oxide/strontium nanocomposite electrodepositing.
PG  - 35-44
LID - S0006-291X(23)00558-2 [pii]
LID - 10.1016/j.bbrc.2023.05.002 [doi]
AB  - Ti(6)Al(4)V is a widely used orthopedic implant material in clinics. Due to its 
      poor antibacterial properties, surface modification is required to prevent 
      peri-implantation infection. However, chemical linkers used for surface 
      modification have generally been reported to have detrimental effects on cell 
      growth. In this work, by optimizing parameters related to electrodeposition, a 
      composite structural coating with graphene oxide (GO) compact films in the inner 
      layer and 35 nm diameter strontium (Sr) nanoparticles in the outer layer was 
      constructed on the surface of Ti(6)Al(4)V without using substance harmful to bone 
      marrow mesenchymal stem cells (BMSCs) growth. The antibacterial properties of 
      Ti(6)Al(4)V are enhanced by the controlled release of Sr ions and incomplete 
      masking of the GO surface, showing excellent antibacterial activity against 
      Staphylococcus aureus in bacterial culture assays. The biomimetic GO/Sr coating 
      has a reduced roughness of the implant surface and a water contact angle of 
      44.1 degrees , improving the adhesion, proliferation and differentiation of BMSCs. 
      Observations of synovial tissue and fluid in the joint in an implantation model 
      of rabbit knee also point to the superior anti-infective properties of the novel 
      GO/Sr coating. In summary, the novel GO/Sr nanocomposite coating on the surface 
      of Ti(6)Al(4)V effectively prevents surface colonization of Staphylococcus aureus 
      and eliminates local infections in vitro and in vivo.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Wang, Xing
AU  - Wang X
AD  - Department of Orthopedics, The First Affiliated Hospital of Air Force Military 
      Medical University, People's Republic of China; Department of Medical 
      Identification, The Air Force Medical Center, Beijing, People's Republic of 
      China.
FAU - Diwu, Weilong
AU  - Diwu W
AD  - Department of Orthopedics, The First Affiliated Hospital of Air Force Military 
      Medical University, People's Republic of China.
FAU - Guo, Jianbin
AU  - Guo J
AD  - Department of Joint Surgery, Hong-Hui Hospital, Xi'an Jiaotong University College 
      of Medicine, People's Republic of China.
FAU - Yan, Ming
AU  - Yan M
AD  - Department of Orthopedics, The First Affiliated Hospital of Air Force Military 
      Medical University, People's Republic of China.
FAU - Ma, Wenrui
AU  - Ma W
AD  - Department of Orthopedics, The First Affiliated Hospital of Air Force Military 
      Medical University, People's Republic of China.
FAU - Yang, Min
AU  - Yang M
AD  - Department of Orthopedics, The First Affiliated Hospital of Air Force Military 
      Medical University, People's Republic of China.
FAU - Bi, Long
AU  - Bi L
AD  - Department of Orthopedics, The First Affiliated Hospital of Air Force Military 
      Medical University, People's Republic of China. Electronic address: 
      bilong@fmmu.edu.cn.
FAU - Han, Yisheng
AU  - Han Y
AD  - Department of Orthopedics, The First Affiliated Hospital of Air Force Military 
      Medical University, People's Republic of China. Electronic address: 
      drhanys@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230502
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (graphene oxide)
RN  - YZS2RPE8LE (Strontium)
RN  - D1JT611TNE (Titanium)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Coated Materials, Biocompatible)
SB  - IM
MH  - Animals
MH  - Rabbits
MH  - Surface Properties
MH  - *Strontium/pharmacology
MH  - Titanium/pharmacology/chemistry
MH  - Staphylococcus aureus
MH  - *Nanocomposites
MH  - Anti-Bacterial Agents/pharmacology/chemistry
MH  - Coated Materials, Biocompatible/pharmacology/chemistry
OTO - NOTNLM
OT  - Antibacterial
OT  - Bioactive materials
OT  - Graphene oxide
OT  - Nanocomposite coating
OT  - Strontium
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/05/08 18:42
MHDA- 2023/05/29 06:42
CRDT- 2023/05/08 18:00
PHST- 2023/03/30 00:00 [received]
PHST- 2023/04/19 00:00 [revised]
PHST- 2023/05/01 00:00 [accepted]
PHST- 2023/05/29 06:42 [medline]
PHST- 2023/05/08 18:42 [pubmed]
PHST- 2023/05/08 18:00 [entrez]
AID - S0006-291X(23)00558-2 [pii]
AID - 10.1016/j.bbrc.2023.05.002 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2023 Jul 12;665:35-44. doi: 
      10.1016/j.bbrc.2023.05.002. Epub 2023 May 2.