PMID- 37156283
OWN - NLM
STAT- MEDLINE
DCOM- 20230526
LR  - 20230526
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 332
DP  - 2023 Aug
TI  - Co-exposure of organophosphorus pesticides is associated with increased risk of 
      type 2 diabetes mellitus in a Chinese population.
PG  - 138865
LID - S0045-6535(23)01132-3 [pii]
LID - 10.1016/j.chemosphere.2023.138865 [doi]
AB  - OBJECTIVE: The epidemiological evidence of human exposure to organophosphorus 
      pesticides (OPPs) with type 2 diabetes mellitus (T2DM) and prediabetes (PDM) is 
      scarce. We aimed to examine the association of T2DM/PDM risk with single OPP 
      exposure and multi-OPP co-exposure. METHODS: Plasma levels of ten OPPs were 
      measured using the gas chromatography-triple quadrupole mass spectrometry 
      (GC-MS/MS) among 2734 subjects from the Henan Rural Cohort Study. We used 
      generalized linear regression to estimate odds ratios (ORs) or beta with 95% 
      confidence intervals (CIs), and constructed quantile g-computation and Bayesian 
      kernel machine regression (BKMR) models to investigate the association of OPPs 
      mixture with the risk of T2DM and PDM. RESULTS: High detection rates ranged from 
      76.35% (isazophos) to 99.17% (malathion and methidathion) for all OPPs. Several 
      plasma OPPs concentrations were in positive correlation with T2DM and PDM. 
      Additionally, positive associations of several OPPs with fasting plasma glucose 
      (FPG) values and glycosylated hemoglobin (HbA1c) levels were observed. In the 
      quantile g-computation, we identified significantly positive associations between 
      OPPs mixtures and T2DM as well as PDM, and fenthion had the greatest contribution 
      for T2DM, followed by fenitrothion and cadusafos. As for PDM, the increased risk 
      was largely explained by cadusafos, fenthion, and malathion. Furthermore, BKMR 
      models suggested that co-exposure to OPPs was linked to an increased risk of T2DM 
      and PDM. CONCLUSION: Our findings suggested that the individual and mixture of 
      OPPs exposure were associated with an increased risk of T2DM and PDM, implying 
      that OPPs might act an important role in the development of T2DM.
CI  - Copyright (c) 2023. Published by Elsevier Ltd.
FAU - Ma, Cuicui
AU  - Ma C
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Wei, Dandan
AU  - Wei D
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Wang, Lulu
AU  - Wang L
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Xu, Qingqing
AU  - Xu Q
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Wang, Juan
AU  - Wang J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Shi, Jiayu
AU  - Shi J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Geng, Jintian
AU  - Geng J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Zhao, Mengzhen
AU  - Zhao M
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Huo, Wenqian
AU  - Huo W
AD  - Department of Occupational and Environmental Health Sciences, College of Public 
      Health, Zhengzhou University, Zhengzhou, Henan, PR China.
FAU - Wang, Chongjian
AU  - Wang C
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Mao, Zhenxing
AU  - Mao Z
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China. Electronic address: maozhr@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230506
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 8JBJ4VO75K (cadusafos)
RN  - BL0L45OVKT (Fenthion)
RN  - U5N7SU872W (Malathion)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Pesticides)
SB  - IM
MH  - Humans
MH  - Bayes Theorem
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - East Asian People
MH  - Fenthion
MH  - Gas Chromatography-Mass Spectrometry
MH  - Malathion
MH  - *Organophosphorus Compounds/adverse effects
MH  - *Pesticides/adverse effects
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Joint effect
OT  - Organophosphorus pesticides
OT  - Quantile g-computation
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/05/09 00:42
MHDA- 2023/05/26 06:42
CRDT- 2023/05/08 19:20
PHST- 2022/11/24 00:00 [received]
PHST- 2023/03/30 00:00 [revised]
PHST- 2023/05/05 00:00 [accepted]
PHST- 2023/05/26 06:42 [medline]
PHST- 2023/05/09 00:42 [pubmed]
PHST- 2023/05/08 19:20 [entrez]
AID - S0045-6535(23)01132-3 [pii]
AID - 10.1016/j.chemosphere.2023.138865 [doi]
PST - ppublish
SO  - Chemosphere. 2023 Aug;332:138865. doi: 10.1016/j.chemosphere.2023.138865. Epub 
      2023 May 6.