PMID- 37157958
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240204
IS  - 2234-2400 (Print)
IS  - 2234-2443 (Electronic)
IS  - 2234-2400 (Linking)
VI  - 57
IP  - 1
DP  - 2024 Jan
TI  - Endoscopic radiofrequency Stretta therapy reduces proton pump inhibitor 
      dependency and the need for anti-reflux surgery for refractory gastroesophageal 
      reflux disease.
PG  - 58-64
LID - 10.5946/ce.2023.026 [doi]
AB  - BACKGROUND/AIMS: Radiofrequency treatment of the gastroesophageal junction using 
      the Stretta procedure for treating gastroesophageal reflux disease (GERD) is 
      observed to improve the symptoms and proton pump inhibitor (PPI) dependence and 
      reduce the need for anti-reflux operations. As one of the largest studies in 
      Europe, we evaluated the clinical outcomes of Stretta in patients with medically 
      refractory GERD. METHODS: A tertiary UK center evaluated all patients with 
      refractory GERD who underwent Stretta between 2014 and 2022. Patients and primary 
      care professionals were contacted to obtain information regarding the initiation 
      of PPI and reintervention after Stretta. RESULTS: Of the 195 patients (median 
      age, 55 years; 116 women [59.5%]) who underwent Stretta, PPI-free period (PFP) 
      data were available for 144 (73.8%) patients. Overall, 66 patients (45.8%) did 
      not receive PPI after a median follow-up of 55 months. Six patients (3.1%) 
      underwent further interventions. The median PFP after Stretta was 41 months. 
      There was a significant negative correlation between PFP and age (p=0.007), with 
      no differences between sexes (p=0.96). Patients younger than 55 years of age had 
      a longer PFP than their older counterparts (p=0.005). Younger males had a 
      significantly longer PFP than older males (p=0.021). However, this was not 
      observed in the female cohort (p=0.09) or between the younger men and women 
      (p=0.66). CONCLUSION: Our findings suggest that Stretta is a safe and feasible 
      option for treating refractory GERD, especially in younger patients. It prevents 
      further anti-reflux interventions in most patients and increases the lead-time to 
      surgery in patients with refractory GERD.
FAU - Joel, Abraham
AU  - Joel A
AD  - Department of General and Upper Gastrointestinal Surgery, James Cook University 
      Hospital, Cleveland, UK.
FAU - Konjengbam, Alakh
AU  - Konjengbam A
AD  - Department of General and Upper Gastrointestinal Surgery, James Cook University 
      Hospital, Cleveland, UK.
FAU - Viswanath, Yirupaiahgari
AU  - Viswanath Y
AD  - Department of General and Upper Gastrointestinal Surgery, James Cook University 
      Hospital, Cleveland, UK.
FAU - Kourounis, Georgios
AU  - Kourounis G
AD  - Department of General and Upper Gastrointestinal Surgery, James Cook University 
      Hospital, Cleveland, UK.
FAU - Hammond, Emily
AU  - Hammond E
AD  - Department of General and Upper Gastrointestinal Surgery, James Cook University 
      Hospital, Cleveland, UK.
FAU - Frank, Helen
AU  - Frank H
AD  - Department of General and Upper Gastrointestinal Surgery, James Cook University 
      Hospital, Cleveland, UK.
FAU - Kuttuva, Shivani
AU  - Kuttuva S
AD  - Department of General and Upper Gastrointestinal Surgery, James Cook University 
      Hospital, Cleveland, UK.
FAU - Mbarushimana, Simon
AU  - Mbarushimana S
AD  - Department of General and Upper Gastrointestinal Surgery, James Cook University 
      Hospital, Cleveland, UK.
FAU - Hidayat, Hena
AU  - Hidayat H
AD  - Department of General and Upper Gastrointestinal Surgery, James Cook University 
      Hospital, Cleveland, UK.
FAU - Thulasiraman, Srivishnu
AU  - Thulasiraman S
AD  - Department of General and Upper Gastrointestinal Surgery, James Cook University 
      Hospital, Cleveland, UK.
LA  - eng
PT  - Journal Article
DEP - 20230502
PL  - Korea (South)
TA  - Clin Endosc
JT  - Clinical endoscopy
JID - 101576886
CIN - Clin Endosc. 2024 Jan;57(1):48-50. PMID: 38204168
PMC - PMC10834287
OTO - NOTNLM
OT  - Fundoplicatio
OT  - Gastrooesophageal reflux
OT  - Proton pump inhibitors
OT  - Radiofrequency therapy
COIS- Conflicts of Interest The authors have no potential conflicts of interest.
EDAT- 2023/05/09 06:42
MHDA- 2023/05/09 06:43
PMCR- 2024/01/01
CRDT- 2023/05/09 03:51
PHST- 2023/01/14 00:00 [received]
PHST- 2023/02/08 00:00 [accepted]
PHST- 2023/05/09 06:43 [medline]
PHST- 2023/05/09 06:42 [pubmed]
PHST- 2023/05/09 03:51 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - ce.2023.026 [pii]
AID - ce-2023-026 [pii]
AID - 10.5946/ce.2023.026 [doi]
PST - ppublish
SO  - Clin Endosc. 2024 Jan;57(1):58-64. doi: 10.5946/ce.2023.026. Epub 2023 May 2.