PMID- 37157963
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240204
IS  - 2234-2400 (Print)
IS  - 2234-2443 (Electronic)
IS  - 2234-2400 (Linking)
VI  - 57
IP  - 1
DP  - 2024 Jan
TI  - Association between occurrence of multiple white and flat elevated gastric 
      lesions and oral proton pump inhibitor intake.
PG  - 65-72
LID - 10.5946/ce.2022.257 [doi]
AB  - BACKGROUND/AIMS: Multiple white and flat elevated lesions (MWFL) that develop 
      from the gastric corpus to the fornix may be strongly associated with oral 
      antacid intake. Therefore, this study aimed to determine the association between 
      the occurrence of MWFL and oral proton pump inhibitor (PPI) intake and clarify 
      the endoscopic and clinicopathological characteristics of MWFL. METHODS: The 
      study included 163 patients. The history of oral drug intake was collected, and 
      serum gastrin levels and anti-Helicobacter pylori immunoglobulin G antibody 
      titers were measured. Upper gastrointestinal endoscopy was performed. The primary 
      study endpoint was the association between MWFL and oral PPI intake. RESULTS: In 
      the univariate analyses, MWFL were observed in 35 (49.3%) of 71 patients who 
      received oral PPIs and 10 (10.9%) of 92 patients who did not receive oral PPIs. 
      The occurrence of MWFL was significantly higher among patients who received PPIs 
      than in those who did not (p<0.001). Moreover, the occurrence of MWFL was 
      significantly higher in patients with hypergastrinemia (p=0.005). In the 
      multivariate analyses, oral PPI intake was the only significant independent 
      factor associated with the presence of MWFL (p=0.001; odds ratio, 5.78; 95% 
      confidence interval, 2.06-16.2). CONCLUSION: Our findings suggest that oral PPI 
      intake is associated with the presence of MWFL (UMINCTR 000030144).
FAU - Hasegawa, Rino
AU  - Hasegawa R
AD  - Department of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
FAU - Yao, Kenshi
AU  - Yao K
AD  - Department of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
FAU - Kanemitsu, Takao
AU  - Kanemitsu T
AD  - Department of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
FAU - Arima, Hisatomi
AU  - Arima H
AD  - Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka 
      University, Fukuoka, Japan.
FAU - Hirase, Takayuki
AU  - Hirase T
AD  - Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, 
      Japan.
FAU - Hiratsuka, Yuuya
AU  - Hiratsuka Y
AD  - Department of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
FAU - Takeda, Kazuhiro
AU  - Takeda K
AD  - Department of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
FAU - Imamura, Kentaro
AU  - Imamura K
AD  - Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, 
      Japan.
FAU - Ohtsu, Kensei
AU  - Ohtsu K
AD  - Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, 
      Japan.
FAU - Ono, Yoichiro
AU  - Ono Y
AD  - Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, 
      Japan.
FAU - Miyaoka, Masaki
AU  - Miyaoka M
AD  - Department of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
FAU - Hisabe, Takashi
AU  - Hisabe T
AD  - Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, 
      Japan.
FAU - Ueki, Toshiharu
AU  - Ueki T
AD  - Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, 
      Japan.
FAU - Tanabe, Hiroshi
AU  - Tanabe H
AD  - Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
FAU - Ohta, Atsuko
AU  - Ohta A
AD  - Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
FAU - Nimura, Satoshi
AU  - Nimura S
AD  - Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230509
PL  - Korea (South)
TA  - Clin Endosc
JT  - Clinical endoscopy
JID - 101576886
CIN - Clin Endosc. 2024 Jan;57(1):51-52. PMID: 38204169
PMC - PMC10834278
OTO - NOTNLM
OT  - Hypergastrinemic
OT  - Multiple white and flat elevated lesions
OT  - Proton pump inhibitors
OT  - Stomach
COIS- Conflicts of Interest The authors have no potential conflicts of interest.
EDAT- 2023/05/09 06:42
MHDA- 2023/05/09 06:43
PMCR- 2024/01/01
CRDT- 2023/05/09 03:51
PHST- 2022/09/07 00:00 [received]
PHST- 2022/11/27 00:00 [accepted]
PHST- 2023/05/09 06:43 [medline]
PHST- 2023/05/09 06:42 [pubmed]
PHST- 2023/05/09 03:51 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - ce.2022.257 [pii]
AID - ce-2022-257 [pii]
AID - 10.5946/ce.2022.257 [doi]
PST - ppublish
SO  - Clin Endosc. 2024 Jan;57(1):65-72. doi: 10.5946/ce.2022.257. Epub 2023 May 9.