PMID- 3715886
OWN - NLM
STAT- MEDLINE
DCOM- 19860718
LR  - 20190727
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 84
IP  - 2
DP  - 1986 Jun 30
TI  - Developmental toxicology of trimethyltin in the rat.
PG  - 412-7
AB  - Pregnant rats were treated on either gestational day (GD) 7, 12, or 17 with 
      single doses of trimethyltin chloride (TMT) ip at either 0, 5, 7, or 9 mg/kg. A 
      significant effect of dose was manifest as decreased maternal weight at term, 
      which persisted during lactation until postnatal day (PND) 15 in some groups. For 
      all treatments combined, term weights of dams exposed on GDs 7 and 12 were 
      greater than those treated on GD 17. Litter sizes were decreased for groups 
      treated on GD 17 with 9 mg/kg TMT. Pups treated in utero and exhibiting 
      treatment-induced decreases in weight at or near birth remained smaller than 
      untreated animals into adulthood (PND 280). By PND 20, weights of pups treated on 
      GD 7 greater than GD 12 greater than GD 17. Neuropathology of pups sacrificed on 
      PND 1 was minimal in all animals with lesions only identified in animals treated 
      on GDs 12 or 17 which consisted of subtle degenerative changes in the CA3 and CA4 
      regions of Ammon's horn of the hippocampus. Muscarinic cholinergic receptor 
      binding in whole brains from pups on PND 1 did not show any significant changes 
      compared to controls for any dose or day of exposure. These data indicate that 
      prenatal TMT exposure results in postnatal toxicity in treated pups but only in 
      the presence of maternal toxicity.
FAU - Paule, M G
AU  - Paule MG
FAU - Reuhl, K
AU  - Reuhl K
FAU - Chen, J J
AU  - Chen JJ
FAU - Ali, S F
AU  - Ali SF
FAU - Slikker, W Jr
AU  - Slikker W Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Trimethyltin Compounds)
RN  - 1631-73-8 (trimethyltin)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Brain/*drug effects
MH  - Embryonic and Fetal Development/drug effects
MH  - Female
MH  - Gestational Age
MH  - Injections, Intraperitoneal
MH  - Litter Size/drug effects
MH  - Maternal-Fetal Exchange
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Trimethyltin Compounds
EDAT- 1986/06/30 00:00
MHDA- 2001/03/28 10:01
CRDT- 1986/06/30 00:00
PHST- 1986/06/30 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1986/06/30 00:00 [entrez]
AID - 0041-008X(86)90149-3 [pii]
AID - 10.1016/0041-008x(86)90149-3 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 1986 Jun 30;84(2):412-7. doi: 
      10.1016/0041-008x(86)90149-3.