PMID- 37160141
OWN - NLM
STAT- MEDLINE
DCOM- 20230511
LR  - 20230513
IS  - 1678-4227 (Electronic)
IS  - 0004-282X (Print)
IS  - 0004-282X (Linking)
VI  - 81
IP  - 4
DP  - 2023 Apr
TI  - Molecular mimicry between Zika virus and central nervous system inflammatory 
      demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens.
PG  - 357-368
LID - 10.1055/s-0043-1768698 [doi]
AB  - BACKGROUND: Evidence indicates a strong link between Zika virus (ZikV) and 
      neurological complications. Acute myelitis, optic neuritis, polyneuropathy, and 
      encephalomyelitis that mimic inflammatory idiopathic demyelination disorders 
      (IIDD) after ZikV infection have been reported in Brazil. OBJECTIVE: The present 
      study aims to investigate the possible occurrence of molecular mimicry between 
      ZikV antigens and Multiple Sclerosis (MS) autoantigens, the most frequent IIDD of 
      the central nervous system (CNS). METHODS: A retrospective cohort study with 305 
      patients admitted due to suspected arbovirus infection in Rio de Janeiro was 
      performed, all subjects were submitted to neurological examination, and a 
      biological sample was collected for serologic and molecular diagnostic. 
      Bioinformatics tools were used to analyze the peptides shared between ZikV 
      antigens and MS autoantigens. RESULTS: Of 305 patients, twenty-six were positive 
      for ZikV and 4 presented IDD patterns found in MS cases. Sequence homology 
      comparisons by bioinformatics approach between NS5 ZikV and PLP MS protein 
      revealed a homology of 5/6 consecutive amino acids (CSSVPV/CSAVPV) with 83% 
      identity, deducing a molecular mimicry. Analysis of the 3D structures revealed a 
      similar conformation with alpha helix presentation. CONCLUSIONS: Molecular 
      mimicry between NS5 Zika virus antigen and PLP MS autoantigens emerge as a 
      possible mechanism for IDD spectrum in genetically susceptible individuals.
CI  - Academia Brasileira de Neurologia. This is an open access article published by 
      Thieme under the terms of the Creative Commons Attribution 4.0 International 
      License, permitting copying and reproduction so long as the original work is 
      given appropriate credit (https://creativecommons.org/licenses/by/4.0/).
FAU - Franca, Laise Carolina
AU  - Franca LC
AUID- ORCID: 0000-0001-8851-7845
AD  - Universidade Federal do Estado do Rio de Janeiro, Programa de Pos-Graduacao em 
      Neurologia, Laboratorio de Neurociencias Translacional, Rio de Janeiro RJ, 
      Brazil.
FAU - Fontes-Dantas, Fabricia Lima
AU  - Fontes-Dantas FL
AUID- ORCID: 0000-0002-5201-0927
AD  - Universidade Federal do Estado do Rio de Janeiro, Programa de Pos-Graduacao em 
      Neurologia, Laboratorio de Neurociencias Translacional, Rio de Janeiro RJ, 
      Brazil.
AD  - Universidade do Estado do Rio de Janeiro, Departamento de Farmacologia e 
      Psicobiologia, Rio de Janeiro RJ, Brazil.
FAU - Garcia, Diogo Gomes
AU  - Garcia DG
AUID- ORCID: 0000-0002-3434-1589
AD  - Universidade Federal do Estado do Rio de Janeiro, Programa de Pos-Graduacao em 
      Neurologia, Laboratorio de Neurociencias Translacional, Rio de Janeiro RJ, 
      Brazil.
FAU - de Araujo, Amanda Dutra
AU  - de Araujo AD
AUID- ORCID: 0000-0001-6233-1428
AD  - Universidade Federal do Estado do Rio de Janeiro, Programa de Pos-Graduacao em 
      Neurologia, Laboratorio de Neurociencias Translacional, Rio de Janeiro RJ, 
      Brazil.
FAU - da Costa Goncalves, Joao Paulo
AU  - da Costa Goncalves JP
AUID- ORCID: 0000-0003-2621-3138
AD  - Universidade Federal do Estado do Rio de Janeiro, Programa de Pos-Graduacao em 
      Neurologia, Laboratorio de Neurociencias Translacional, Rio de Janeiro RJ, 
      Brazil.
FAU - Rego, Claudia Cecilia da Silva
AU  - Rego CCDS
AUID- ORCID: 0000-0002-1837-4401
AD  - Universidade Federal do Estado do Rio de Janeiro, Programa de Pos-Graduacao em 
      Neurologia, Laboratorio de Neurociencias Translacional, Rio de Janeiro RJ, 
      Brazil.
FAU - da Silva, Elielson Veloso
AU  - da Silva EV
AUID- ORCID: 0000-0002-5355-0538
AD  - Universidade Federal do Estado do Rio de Janeiro, Programa de Pos-Graduacao em 
      Neurologia, Laboratorio de Neurociencias Translacional, Rio de Janeiro RJ, 
      Brazil.
FAU - do Nascimento, Osvaldo Jose Moreira
AU  - do Nascimento OJM
AUID- ORCID: 0000-0003-3516-485X
AD  - Universidade Federal Fluminense, Hospital Universitario Antonio Pedro, 
      Departamento de Neurologia, Niteroi RJ, Brazil.
FAU - Lopes, Fernanda Cristina Rueda
AU  - Lopes FCR
AUID- ORCID: 0000-0002-3782-8624
AD  - Universidade Federal Fluminense, Hospital Universitario Antonio Pedro, 
      Departamento de Radiologia, Niteroi RJ, Brazil.
FAU - Herlinger, Alice Laschuk
AU  - Herlinger AL
AUID- ORCID: 0000-0002-7660-7058
AD  - Universidade Federal Fluminense, Hospital Universitario Antonio Pedro, 
      Departamento de Radiologia, Niteroi RJ, Brazil.
FAU - de Aguiar, Renato Santana
AU  - de Aguiar RS
AUID- ORCID: 0000-0001-5180-3717
AD  - Universidade Federal Fluminense, Hospital Universitario Antonio Pedro, 
      Departamento de Radiologia, Niteroi RJ, Brazil.
FAU - da Costa Ferreira Junior, Orlando
AU  - da Costa Ferreira Junior O
AUID- ORCID: 0000-0002-1970-8936
AD  - Universidade Federal do Rio de Janeiro, Instituto de Biologia, Departamento de 
      Genetica, Rio de Janeiro RJ, Brazil.
FAU - Figueira, Fernando Faria Andrade
AU  - Figueira FFA
AUID- ORCID: 0000-0003-3242-9007
AD  - Hospital Sao Francisco na Providencia de Deus, Departamento de Neurologia, Rio de 
      Janeiro RJ, Brazil.
FAU - de Souza, Jorge Paes Barreto Marcondes
AU  - de Souza JPBM
AUID- ORCID: 0000-0003-2412-8239
AD  - Universidade Federal do Estado do Rio de Janeiro, Programa de Pos-Graduacao em 
      Neurologia, Laboratorio de Neurociencias Translacional, Rio de Janeiro RJ, 
      Brazil.
AD  - Universidade Federal do Rio de Janeiro, Hospital Universitario Clementino Fraga 
      Filho, Departamento de Neurocirurgia, Rio de Janeiro RJ, Brazil.
FAU - De Mesquita, Joelma Freire
AU  - De Mesquita JF
AUID- ORCID: 0000-0003-1684-3830
AD  - Universidade Federal do Estado do Rio de Janeiro, Departamento de Genetica e 
      Biologia Molecular, Grupo de Bioinformatica e Biologia Computacional, Rio de 
      Janeiro RJ, Brazil.
FAU - Alves-Leon, Soniza Vieira
AU  - Alves-Leon SV
AUID- ORCID: 0000-0002-1538-6730
AD  - Universidade Federal do Estado do Rio de Janeiro, Programa de Pos-Graduacao em 
      Neurologia, Laboratorio de Neurociencias Translacional, Rio de Janeiro RJ, 
      Brazil.
AD  - Universidade Federal do Rio de Janeiro, Hospital Universitario Clementino Fraga 
      Filho, Centro de Referencia e Pesquisa em Esclerose Multipla e Outras Doencas 
      Desmielinizantes Inflamatorias Idiopaticas do SNC, Rio de Janeiro RJ, Brazil.
LA  - eng
PT  - Journal Article
TT  - Mimetismo molecular entre o virus Zika e os disturbios inflamatorios 
      desmielinizantes do sistema nervoso central: o papel do epitopo NS5 do virus Zika 
      e dos autoantigenos PLP.
DEP - 20230509
PL  - Germany
TA  - Arq Neuropsiquiatr
JT  - Arquivos de neuro-psiquiatria
JID - 0125444
RN  - 0 (Epitopes)
RN  - 0 (Autoantigens)
SB  - IM
MH  - Humans
MH  - Epitopes
MH  - Molecular Mimicry
MH  - *Zika Virus
MH  - Autoantigens
MH  - *Zika Virus Infection
MH  - Retrospective Studies
MH  - Brazil
MH  - *Central Nervous System Diseases
MH  - *Multiple Sclerosis
MH  - Central Nervous System
PMC - PMC10169219
COIS- There is no conflict of interest to declare.
EDAT- 2023/05/10 00:41
MHDA- 2023/05/11 06:42
PMCR- 2023/05/01
CRDT- 2023/05/09 19:03
PHST- 2023/05/11 06:42 [medline]
PHST- 2023/05/10 00:41 [pubmed]
PHST- 2023/05/09 19:03 [entrez]
PHST- 2023/05/01 00:00 [pmc-release]
AID - ANP-22-0092 [pii]
AID - 10.1055/s-0043-1768698 [doi]
PST - ppublish
SO  - Arq Neuropsiquiatr. 2023 Apr;81(4):357-368. doi: 10.1055/s-0043-1768698. Epub 
      2023 May 9.