PMID- 37160278
OWN - NLM
STAT- MEDLINE
DCOM- 20230609
LR  - 20231003
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 108
IP  - 6
DP  - 2023 Jun 7
TI  - Vision Loss in Subacute Sclerosing Panencephalitis: A Systematic Review of Case 
      Reports and Case Series.
PG  - 1272-1276
LID - 10.4269/ajtmh.23-0004 [doi]
AB  - Vision loss is a presenting complaint in many patients with subacute sclerosing 
      panencephalitis (SSPE). Data related to vision loss in SSPE is available only in 
      the form of case reports. In this systematic review, we evaluated characteristics 
      of vision loss, affected anatomic site, and patient course and outcome. We 
      extracted data from four databases: PubMed, Embase, Scopus, and Google Scholar. 
      The last search was done on October 26, 2022. We adhered to Preferred Reporting 
      Items for Systematic Reviews and Meta-Analyses guidelines. The protocol was 
      registered with PROSPERO (CRD42022362652). Dyken's criteria were used for the 
      diagnosis of SSPE. The data were recorded in an Excel sheet. The Joanna Briggs 
      Institute Critical Appraisal tool was used to assess the quality of data. The 
      mean age of patients with SSPE was 17.9 years. Males outnumbered females (60:34). 
      In 73 patients (76%), duration of illness/onset of vision loss was less than 6 
      months. In 76% patients (n = 73), visual manifestations appeared before 
      encephalopathy. Involvement of the retina (58 of 96, 60.4%), optic nerve (9 of 
      96, 9.3%), or cerebral cortex (29 of 96, 30.2%) was responsible for vision loss. 
      T2/fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) 
      parieto-occipital hyperintensities were the most frequent (71.4%) neuroimaging 
      abnormality. Retinal biopsy revealed similar findings revealed by brain 
      histopathology. All patients died and became akinetic mute during the follow-up 
      period, which ranged from a few weeks to a few years. In conclusion, retinal 
      involvement was the most common cause of vision loss. Vision loss often precedes 
      encephalopathy. Cortical vision loss was associated invariably with T2/FLAIR MRI 
      hyperintensities in the parieto-occipital region.
FAU - Garg, Ravindra Kumar
AU  - Garg RK
AD  - Department of Neurology, King George's Medical University, Lucknow, India.
FAU - Paliwal, Vimal
AU  - Paliwal V
AD  - Department of Neurology, Sanjay Gandhi Institute of Medical Sciences, Lucknow, 
      India.
FAU - Kumar, Neeraj
AU  - Kumar N
AD  - Department of Neurology, King George's Medical University, Lucknow, India.
FAU - Agrawal, Akshaya Anand
AU  - Agrawal AA
AD  - Department of Surgery, King George's Medical University, Lucknow, India.
FAU - Agrawal, Preeti
AU  - Agrawal P
AD  - Department of Pathology, King George's Medical University, Lucknow, India.
FAU - Rizvi, Imran
AU  - Rizvi I
AD  - Department of Neurology, King George's Medical University, Lucknow, India.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Systematic Review
DEP - 20230509
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Adolescent
MH  - *Subacute Sclerosing Panencephalitis/diagnosis/diagnostic imaging
MH  - Brain/pathology
MH  - Vision Disorders/etiology
MH  - Magnetic Resonance Imaging
MH  - Neuroimaging
PMC - PMC10540115
EDAT- 2023/05/10 00:41
MHDA- 2023/06/09 06:42
PMCR- 2024/06/01
CRDT- 2023/05/09 20:02
PHST- 2023/01/01 00:00 [received]
PHST- 2023/03/12 00:00 [accepted]
PHST- 2024/06/01 00:00 [pmc-release]
PHST- 2023/06/09 06:42 [medline]
PHST- 2023/05/10 00:41 [pubmed]
PHST- 2023/05/09 20:02 [entrez]
AID - tpmd230004 [pii]
AID - 10.4269/ajtmh.23-0004 [doi]
PST - epublish
SO  - Am J Trop Med Hyg. 2023 May 9;108(6):1272-1276. doi: 10.4269/ajtmh.23-0004. Print 
      2023 Jun 7.