PMID- 37161459
OWN - NLM
STAT- MEDLINE
DCOM- 20230519
LR  - 20230622
IS  - 0974-7559 (Electronic)
IS  - 0019-6061 (Print)
IS  - 0019-6061 (Linking)
VI  - 60
IP  - 5
DP  - 2023 May 15
TI  - Cardiac Outcome of Children With SARS-CoV-2 Related Multisystem Inflammatory 
      Syndrome.
PG  - 381-384
LID - S097475591600517 [pii]
AB  - OBJECTIVE: To study the cardiac outcomes of patients with multisystem 
      inflammatory syndrome in children (MIS-C) after 6-month of diagnosis. METHODS: 
      This review of hospital records was conducted on MIS-C patients (aged <21 year) 
      who completed a six-month follow up. The baseline demographic, clinical, 
      laboratory, and treatment characteristics during the acute phase, and 
      echocardiographic findings during follow-up were collected. RESULTS: 116 patients 
      (61.2% male, median age 7 years) with MIS-C were included in the study. At the 
      time of admission, cardiac abnormalities were present in 70.7% of MIS-C patients, 
      and the most common cardiac abnormalities were valve failure (50.9%), followed by 
      ventricular dysfunction (39.7%), and pericardial effusion (23.3%). Six month 
      after diagnosis, cardiac abnormalities were found in 10.3% of patients, and 
      patients had lower rates of ventricular dysfunction (P<0.001), valve failure 
      (P<0.001), pericardial effusion (P<0.001), and coronary involvement (P<0.001) as 
      composed to the baseline. Intravenous immunoglobulin (IVIG) and steroid treatment 
      significantly reduced the odds of occurrence of ventricular dysfunction 
      (P=0.002), valve failure (P=0.004), and low ejection fraction (P=0.002) in 
      comparison to IVIG treatment. CONCLUSION: While most MIS-C patients had abnormal 
      echocardiographic findings at admission, only 10.3% of patients had cardiac 
      abnormalities during follow up.
FAU - Ghodsi, Ali Reza
AU  - Ghodsi AR
AD  - Department of Pediatrics, Faculty of Medicine, AJA University of Medical 
      Sciences, Tehran, Iran.
FAU - Malek, Abdolreza
AU  - Malek A
AD  - Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Siroosbakht, Soheila
AU  - Siroosbakht S
AD  - Department of Pediatrics, Faculty of Medicine, AJA University of Medical 
      Sciences, Tehran, Iran.
FAU - Aminian, Alireza
AU  - Aminian A
AD  - Department of Pediatrics, Faculty of Medicine, AJA University of Medical 
      Sciences, Tehran, Iran.
FAU - Dormanesh, Banafshe
AU  - Dormanesh B
AD  - Department of Pediatrics, Faculty of Medicine, AJA University of Medical 
      Sciences, Tehran, Iran.
FAU - Azarfar, Anoush
AU  - Azarfar A
AD  - Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Zoshk, Mojtaba Yousefi
AU  - Zoshk MY
AD  - Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran Correspondence to: Dr MY Zoshk, Department of Pediatrics, 
      Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran. 
      dr.yousefi.md@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230320
PL  - India
TA  - Indian Pediatr
JT  - Indian pediatrics
JID - 2985062R
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Steroids)
RN  - pediatric multisystem inflammatory disease, COVID-19 related
SB  - IM
MH  - *Systemic Inflammatory Response Syndrome/diagnosis/therapy
MH  - *COVID-19/diagnosis/therapy
MH  - Ventricular Dysfunction
MH  - Pericardial Effusion
MH  - Heart Valve Diseases
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Echocardiography
MH  - Stroke Volume
MH  - *Heart Defects, Congenital
MH  - Steroids/therapeutic use
MH  - Humans
MH  - Male
MH  - Female
MH  - Child, Preschool
MH  - Child
PMC - PMC10185953
EDAT- 2023/05/10 06:42
MHDA- 2023/05/11 06:41
PMCR- 2023/05/16
CRDT- 2023/05/10 03:55
PHST- 2023/05/11 06:41 [medline]
PHST- 2023/05/10 06:42 [pubmed]
PHST- 2023/05/10 03:55 [entrez]
PHST- 2023/05/16 00:00 [pmc-release]
AID - S097475591600517 [pii]
AID - 2885 [pii]
AID - 10.1007/s13312-023-2885-2 [doi]
PST - ppublish
SO  - Indian Pediatr. 2023 May 15;60(5):381-384. doi: 10.1007/s13312-023-2885-2. Epub 
      2023 Mar 20.