PMID- 37162776
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230511
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 4
DP  - 2023 Apr
TI  - Comparison of Coronary Artery Bypass Grafting Combined With Mitral Valve Repair 
      Versus Coronary Artery Bypass Grafting Alone in Patients With Moderate Ischemic 
      Mitral Regurgitation: A Meta-Analysis.
PG  - e37238
LID - 10.7759/cureus.37238 [doi]
LID - e37238
AB  - The aim of this meta-analysis was to compare clinical outcomes between those who 
      underwent coronary artery bypass grafting (CABG) alone and CABG with mitral valve 
      repair (MVR) in patients with moderate ischemic mitral regurgitation. The present 
      study was conducted following the Preferred Reporting Items for Systematic 
      Reviews and Meta-Analyses (PRISMA) guidelines. Two authors performed a 
      comprehensive search of international databases, including PubMed, EMBASE, and 
      the Cochrane Library, for relevant studies published from inception to March 1, 
      2023. The search was performed again before the submission of the manuscript on 
      March 20, 2023. Primary outcomes assessed in the present meta-analysis included 
      early mortality and long-term mortality. Secondary outcomes assessed in the 
      present meta-analysis included change in New York Heart Association (NYHA) score 
      from baseline, change in ejection fraction (EF) from baseline (%), and major 
      cardiovascular events (MACE). A total of 13 studies were included in the present 
      meta-analysis. Out of 13 included studies, four were randomized control trials 
      (RCTs) and nine were retrospective cohort studies. The pooled analysis showed 
      that early mortality was significantly lower in patients in the CABG group 
      compared to the CABG+MVR group (risk ratio [RR]: 0.47, 95% confidence interval 
      [CI]: 0.31, 0.70). Long-term mortality was also lower in patients who underwent 
      CABG compared to patients in the CABG+MVR group. However, the difference was 
      statistically insignificant (RR: 0.88, 95% CI: 0.77, 1.02). No significant 
      differences were reported in the EF score between patients who underwent CABG and 
      patients who underwent CABG plus MVR (mean difference [MD]: 0.40, 95% CI: -1.90, 
      2.69). NYHA score was significantly lower in patients in the CABG+repair group 
      compared to the CABG alone group (MD: 0.39, 95% CI: 0.06, 0.72). In conclusion, 
      our meta-analysis suggests that concomitant MVR during CABG may not improve 
      clinical outcomes in patients with moderate ischemic mitral regurgitation. 
      Further clinical trials are needed to investigate this intervention in more 
      detail.
CI  - Copyright (c) 2023, Sameer et al.
FAU - Sameer, Muhammad Ali
AU  - Sameer MA
AD  - Internal Medicine, CMH Lahore Medical College and Institute of Dentistry, Lahore, 
      PAK.
FAU - Malik, Bilal Aziz
AU  - Malik BA
AD  - Internal Medicine, CMH Lahore Medical College and Institute of Dentistry, Lahore, 
      PAK.
FAU - Choudry, Muhammad Obaid Ullah
AU  - Choudry MOU
AD  - Internal Medicine, CMH Lahore Medical College and Institute of Dentistry, Lahore, 
      PAK.
FAU - Anwar, Muhammad Shoaib
AU  - Anwar MS
AD  - Pharmacology and Therapeutics, CMH Lahore Medical College and Institute of 
      Dentistry, Lahore, PAK.
FAU - Nadeem, Muhammad A
AU  - Nadeem MA
AD  - Medicine and Surgery, Shifa International Hospital Islamabad, Islamabad, PAK.
FAU - Mahmood, Fizza
AU  - Mahmood F
AD  - Cardiology/Cardiac Surgery, Shifa College of Medicine, Islamabad, PAK.
FAU - Anwar, Muhammad Zohaib
AU  - Anwar MZ
AD  - Internal Medicine, Aga Khan University, Karachi, PAK.
FAU - Palleti, Sujith K
AU  - Palleti SK
AD  - Nephrology, Edward Hines Jr. Veterans Administration Hospital, Hines, USA.
AD  - Nephrology, Loyola University Medical Center, Maywood, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230407
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10164294
OTO - NOTNLM
OT  - coronary artery bypass
OT  - ischemic mitral regurgitation
OT  - meta-analysis
OT  - mitral valve repair
OT  - mortality
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/05/10 12:42
MHDA- 2023/05/10 12:43
PMCR- 2023/04/07
CRDT- 2023/05/10 11:18
PHST- 2023/04/06 00:00 [accepted]
PHST- 2023/05/10 12:43 [medline]
PHST- 2023/05/10 12:42 [pubmed]
PHST- 2023/05/10 11:18 [entrez]
PHST- 2023/04/07 00:00 [pmc-release]
AID - 10.7759/cureus.37238 [doi]
PST - epublish
SO  - Cureus. 2023 Apr 7;15(4):e37238. doi: 10.7759/cureus.37238. eCollection 2023 Apr.