PMID- 371628
OWN - NLM
STAT- MEDLINE
DCOM- 19790524
LR  - 20190717
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 22
IP  - 4
DP  - 1979 Apr
TI  - Anti-native DNA detection by the Crithidia luciliae method: an improved guide to 
      the diagnosis and clinical management of systemic lupus erythematosus.
PG  - 321-7
AB  - The clinical value of the Crithidia luciliae (CL) method for detection of 
      antibodies to native DNA (nDNA) was assessed. Significant titers were limited 
      almost exclusively to patients with active systemic lupus erythematosus (SLE). 
      Evaluation of sera from patients at the onset of active lupus demonstrated 
      elevated anti-nDNA levels in 80% of subjects with active disease and in 94% of 
      patients with clinically evident lupus nephritis. In longitudinal studies, rising 
      titers of anti-nDNA were invariably accompanied by exacerbation of lupus 
      activity. These findings suggest that the CL method correlates more closely with 
      active SLE than do other anti-DNA methods in common use and indicate that it will 
      prove highly useful in the diagnosis and management of SLE.
FAU - Ballou, S P
AU  - Ballou SP
FAU - Kushner, I
AU  - Kushner I
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Antibodies, Antinuclear)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Antibodies, Antinuclear/*analysis
MH  - Child
MH  - *Crithidia
MH  - DNA/*immunology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Glomerulonephritis/immunology
MH  - Humans
MH  - Longitudinal Studies
MH  - Lupus Erythematosus, Systemic/diagnosis/*immunology
MH  - Middle Aged
EDAT- 1979/04/01 00:00
MHDA- 1979/04/01 00:01
CRDT- 1979/04/01 00:00
PHST- 1979/04/01 00:00 [pubmed]
PHST- 1979/04/01 00:01 [medline]
PHST- 1979/04/01 00:00 [entrez]
AID - 10.1002/art.1780220402 [doi]
PST - ppublish
SO  - Arthritis Rheum. 1979 Apr;22(4):321-7. doi: 10.1002/art.1780220402.