PMID- 37164081
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20230612
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 886
DP  - 2023 Aug 15
TI  - Effects of exposure to chlorinated paraffins on human health: A scoping review.
PG  - 163953
LID - S0048-9697(23)02574-3 [pii]
LID - 10.1016/j.scitotenv.2023.163953 [doi]
AB  - Chlorinated paraffins (CPs) belong to an emerging class of persistent organic 
      pollutants (POPs) widely detected in environmental matrices and human samples. 
      The potential health risks of CPs on humans have initiated intense concerns but 
      there have been few studies focusing on the said topic. Addressing the gap, we 
      make a scoping review on the current global body of evidence from epidemiological 
      and toxicological studies. Furthermore, the management strategies and regulations 
      related to CPs are presented and discussed. There were 70 articles among 11,280 
      records, including four epidemiological studies, one case report, another 
      twenty-nine studies reporting human body burden, and thirty-six toxicological 
      studies, finally included in this review. Additionally, twenty-three management 
      regulation relevant documents/websites were included. CPs exist in human blood, 
      breast milk, placenta, and other tissues. Population-based and laboratory studies 
      suggest that CPs may cause liver and kidney toxicity, developmental toxicity, 
      neurotoxicity, endocrine disorder, immune dysfunction, and reproductive toxicity. 
      CPs with shorter carbon chains and higher chlorine content may be more harmful. 
      In particular, the combined effect of CPs with other pollutants is of great 
      concern. Population-based studies are far from sufficient at present, and most of 
      them are conducted in China or developed countries. Besides, the toxicity 
      assessment studies of CPs are inadequate. In addition, most studies focus on 
      short-chain CPs (SCCPs) while few studies explored the effect of long-chain CPs 
      (LCCPs). Thus, conducting more epidemiological studies in larger populations and 
      toxicological studies combined with new technology methods are of great 
      significance for better understanding the adverse health effects of CPs, which 
      may promote CPs management regulations.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Huang, Jing-Wen
AU  - Huang JW
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Bai, Ya-Ying
AU  - Bai YY
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Zeeshan, Mohammed
AU  - Zeeshan M
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Liu, Ru-Qing
AU  - Liu RQ
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China. Electronic address: liurq@mail.sysu.edu.cn.
FAU - Dong, Guang-Hui
AU  - Dong GH
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China. Electronic address: donggh5@mail.sysu.edu.cn.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20230508
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 8002-74-2 (Paraffin)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Female
MH  - Pregnancy
MH  - Humans
MH  - Paraffin/toxicity/analysis
MH  - *Hydrocarbons, Chlorinated/toxicity/analysis
MH  - Environmental Monitoring/methods
MH  - *Environmental Pollutants/toxicity/analysis
MH  - China
OTO - NOTNLM
OT  - Adverse health effect
OT  - Body burden
OT  - Chlorinated paraffin
OT  - Combined effect
OT  - Management regulations
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/05/11 00:41
MHDA- 2023/06/12 06:42
CRDT- 2023/05/10 19:23
PHST- 2022/12/21 00:00 [received]
PHST- 2023/04/28 00:00 [revised]
PHST- 2023/05/01 00:00 [accepted]
PHST- 2023/06/12 06:42 [medline]
PHST- 2023/05/11 00:41 [pubmed]
PHST- 2023/05/10 19:23 [entrez]
AID - S0048-9697(23)02574-3 [pii]
AID - 10.1016/j.scitotenv.2023.163953 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Aug 15;886:163953. doi: 10.1016/j.scitotenv.2023.163953. 
      Epub 2023 May 8.