PMID- 37164808
OWN - NLM
STAT- MEDLINE
DCOM- 20230703
LR  - 20231122
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 78
IP  - 8
DP  - 2023 Aug
TI  - Image findings of anti-neutrophil cytoplasmic antibody-associated vasculitis 
      involving the skull base.
PG  - e568-e573
LID - S0009-9260(23)00145-9 [pii]
LID - 10.1016/j.crad.2023.04.004 [doi]
AB  - AIM: To investigate computed tomography (CT) and magnetic resonance imaging (MRI) 
      features of skull bases involving anti-neutrophil cytoplasmic antibody 
      (ANCA)-associated vasculitides (AAV). MATERIALS AND METHODS: A retrospective 
      review was undertaken to identify an institutional historical cohort of 17 
      patients with confirmed AAV who underwent CT or MRI and had skull base 
      involvement between 2002 and 2021. Two radiologists reviewed the extent and 
      features of the lesions, bone changes, and other MRI findings. RESULTS: A total 
      of 17 patients (12 men; mean age +/- standard deviation, 46.5 +/- 17.1 years) were 
      selected. AAV presented as infiltrative lesions with involvement at various 
      sites. Most cases involved the paranasal sinuses (PNS; 88%, 15/17), nasopharynx 
      (88%, 15/17), pterygopalatine fossa (82%, 14/17), and parapharyngeal space (82%, 
      14/17), frequently accompanied by mucosal irregularity of the PNS and nasopharynx 
      (71%, 12/17). Central skull base and temporal bone involvement were seen in 53% 
      (9/17) and 38% (6/16) of cases, respectively. On T1-weighted imaging (WI) and 
      T2WI MRI, all lesions (15/15) showed predominant signal iso-intensity to grey 
      matter. CONCLUSIONS: Although radiological findings of AAV are non-specific and 
      skull base involvement is less common, AAV may be considered if infiltrative 
      lesions predominantly involving the PNS, nasopharynx, pterygopalatine fossa, and 
      parapharyngeal space with combined bone changes of skull base are seen.
CI  - Copyright (c) 2023. Published by Elsevier Ltd.
FAU - Yun, S Y
AU  - Yun SY
AD  - Department of Radiology and Research Institute of Radiology, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea; Department of 
      Radiology, Inje University Busan Paik Hospital, Busan, Republic of Korea.
FAU - Choi, Y J
AU  - Choi YJ
AD  - Department of Radiology and Research Institute of Radiology, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic 
      address: jehee23@gmail.com.
FAU - Chung, S R
AU  - Chung SR
AD  - Department of Radiology and Research Institute of Radiology, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Suh, C H
AU  - Suh CH
AD  - Department of Radiology and Research Institute of Radiology, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Kim, S C
AU  - Kim SC
AD  - Department of Radiology and Research Institute of Radiology, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Lee, J H
AU  - Lee JH
AD  - Department of Radiology and Research Institute of Radiology, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Baek, J H
AU  - Baek JH
AD  - Department of Radiology and Research Institute of Radiology, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20230423
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
SB  - IM
MH  - Male
MH  - Humans
MH  - Skull Base
MH  - Tomography, X-Ray Computed/methods
MH  - *Paranasal Sinuses/pathology
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnostic 
      imaging/pathology
MH  - Magnetic Resonance Imaging/methods
MH  - Retrospective Studies
EDAT- 2023/05/11 00:41
MHDA- 2023/07/03 06:41
CRDT- 2023/05/10 21:59
PHST- 2022/07/28 00:00 [received]
PHST- 2023/02/02 00:00 [revised]
PHST- 2023/04/05 00:00 [accepted]
PHST- 2023/07/03 06:41 [medline]
PHST- 2023/05/11 00:41 [pubmed]
PHST- 2023/05/10 21:59 [entrez]
AID - S0009-9260(23)00145-9 [pii]
AID - 10.1016/j.crad.2023.04.004 [doi]
PST - ppublish
SO  - Clin Radiol. 2023 Aug;78(8):e568-e573. doi: 10.1016/j.crad.2023.04.004. Epub 2023 
      Apr 23.