PMID- 37166093
OWN - NLM
STAT- MEDLINE
DCOM- 20230512
LR  - 20230512
IS  - 1670-4959 (Electronic)
IS  - 0023-7213 (Linking)
VI  - 109
IP  - 5
DP  - 2023 May
TI  - [The incidence of postoperative and persistent usage of proton pump inhibitors 
      following surgery].
PG  - 243-249
LID - 10.17992/lbl.2023.05.744 [doi]
AB  - INTRODUCTION: The use of proton pump inhibitors (PPI) has increased over the past 
      decades. Some patients use the medication without an indication. It is possible 
      that new use will start following surgery. The study aimed to examine the 
      incidence of postoperative use of PPI following surgeries and the ratio of new 
      persistent users over three months postoperatively as well as patient- and 
      procedural variables associated with new use and new persistent use. METHODS: 
      Data of surgeries among adults that had undergone surgeries at the National 
      University Hospital of Iceland from 2006 to 2018. The data were from the 
      Icelandic perioperative database, containing information regarding medication 
      usage preceding and following surgeries. The ratio of those who started using PPI 
      within three months of surgery was assessed, and the ratio of persistent users. 
      RESULTS: Altogether, 2886 out of 42.530 patients filled PPI prescription within 
      three months after their first surgery. Annual incidence was 67 per 1.000 
      surgeries, and the ratio of persistent users was 54%, although both the varied 
      between years. The use was more common among women, highest in age group 56-65 
      years old, patients with polypharmacy (5-9 medicines) and who underwent abdominal 
      surgeries. CONCLUSIONS: New postoperative PPI use is common following surgery and 
      half of the patients with new use develop new persistent use. The usage increased 
      similar to the increased number of prescriptions and sales of PPI in other 
      patient groups during the period. The results indicate the need for further 
      monitoring of patients with PPI prescriptions following surgeries in Iceland.
FAU - Kristjansdottir, Thelma Ros
AU  - Kristjansdottir TR
AD  - University of Iceland.
FAU - Sigurdsson, Martin Ingi
AU  - Sigurdsson MI
AD  - Landspitali, University hospital, Faculty of Medicine, University of Iceland.
FAU - Jonsdottir, Freyja
AU  - Jonsdottir F
AD  - Landspitali, University hospital, Faculty of Pharmaceutical Sciences, University 
      of Iceland.
LA  - ice
PT  - English Abstract
PT  - Journal Article
PL  - Iceland
TA  - Laeknabladid
JT  - Laeknabladid
JID - 7901326
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Aged
MH  - *Proton Pump Inhibitors/adverse effects
MH  - Incidence
MH  - *Inappropriate Prescribing
MH  - Hospitals, University
MH  - Polypharmacy
OTO - NOTNLM
OT  - inappropriate prescribing
OT  - persistent use
OT  - polypharmacy
OT  - proton pump inhibitors
OT  - surgery
EDAT- 2023/05/11 13:18
MHDA- 2023/05/12 07:06
CRDT- 2023/05/11 07:43
PHST- 2023/05/12 07:06 [medline]
PHST- 2023/05/11 13:18 [pubmed]
PHST- 2023/05/11 07:43 [entrez]
AID - 10.17992/lbl.2023.05.744 [doi]
PST - ppublish
SO  - Laeknabladid. 2023 May;109(5):243-249. doi: 10.17992/lbl.2023.05.744.