PMID- 37169170
OWN - NLM
STAT- MEDLINE
DCOM- 20230703
LR  - 20230703
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 42
DP  - 2023 Jun
TI  - Short-term effect of macular edema on the peripapillary retinal nerve fiber layer 
      in patients with wet age-related macular degeneration and diabetic macular edema: 
      A comparative study.
PG  - 103602
LID - S1572-1000(23)00329-0 [pii]
LID - 10.1016/j.pdpdt.2023.103602 [doi]
AB  - BACKGROUND: The combined presence of glaucoma and age-related macular 
      degeneration (ARMD), or glaucoma and diabetes mellitus (DM), occur fairly 
      frequently, especially in elderly patients. This study was intended to compare 
      the effect of resolving macular edema due to DM and wet ARMD on peripapillary 
      retinal nerve fiber layer (RNFL) thickness. METHODS: This cross-sectional study 
      included 76 patients with macular edema secondary to DM (n = 40, 52.6%) or wet 
      ARMD (n = 36, 47.4%). The control group was comprised of 34 age and sex-matched 
      healthy subjects. All study participants underwent evaluation of central macular 
      thickness (CMT) and the peripapillary RNFL using spectral domain-optical 
      coherence tomography (SD-OCT). Data from eyes that received an anti-VEGF 
      injection were obtained one month after the procedure and were compared with 
      pre-injection data. RESULTS: The average initial thickness of the global 
      peripapillary RNFL was 98.9 +/- 16.7 (61-163) microm in the macular edema group and 
      92.0 +/- 16.0 (84-115) microm in the control group (p = 0.045). The post-injection 
      global peripapillary RNFL thickness was 97.3 +/- 19.0 (61-163) microm in the macular 
      edema group and 92.2 +/- 18.0 (81-126) microm in the control group (p = 0.187). In the 
      DM group, the changes in global RNFL thickness, as well as central and temporal 
      quadrant thicknesses, were found to correlate significantly with the change in 
      CMT (r = 0.356, p = 0.024; r = 0.545, p < 0.001, respectively). CONCLUSIONS: 
      Macular edema in wet ARMD appeared not to affect RNFL thickness. Differences in 
      the etiology of macular edema can have varied effects on peripapillary RNFL. It 
      is recommended that peripapillary RNFL thickness be evaluated cautiously in DM 
      patients receiving intravitreal anti-VEGF therapy.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Dikmetas, Ozlem
AU  - Dikmetas O
AD  - Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, 
      Turkey. Electronic address: ozlemdikmetas@gmail.com.
FAU - Gungor, Gulce
AU  - Gungor G
AD  - Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, 
      Turkey.
FAU - Kapucu, Yasemin
AU  - Kapucu Y
AD  - Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, 
      Turkey.
FAU - Kocabeyoglu, Sibel
AU  - Kocabeyoglu S
AD  - Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, 
      Turkey.
FAU - Kadayifcilar, Sibel
AU  - Kadayifcilar S
AD  - Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, 
      Turkey.
FAU - Eldem, Bora
AU  - Eldem B
AD  - Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, 
      Turkey.
FAU - Karahan, Sevilay
AU  - Karahan S
AD  - Department of Biostatistics, Hacettepe University School of Medicine, Ankara, 
      Turkey.
FAU - Cankaya, Ali Bulent
AU  - Cankaya AB
AD  - Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230509
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Macular Edema/drug therapy
MH  - *Diabetic Retinopathy/complications/drug therapy
MH  - Cross-Sectional Studies
MH  - Retinal Ganglion Cells
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents
MH  - *Glaucoma/complications
MH  - Tomography, Optical Coherence/methods
MH  - Nerve Fibers
MH  - *Diabetes Mellitus
OTO - NOTNLM
OT  - Age-related macular degeneration
OT  - Diabetic macular edema
OT  - Macular edema
OT  - OCT
OT  - Peripapillary retinal nerve fiber layer
EDAT- 2023/05/12 01:07
MHDA- 2023/07/03 06:41
CRDT- 2023/05/11 19:34
PHST- 2023/01/15 00:00 [received]
PHST- 2023/04/19 00:00 [revised]
PHST- 2023/05/08 00:00 [accepted]
PHST- 2023/07/03 06:41 [medline]
PHST- 2023/05/12 01:07 [pubmed]
PHST- 2023/05/11 19:34 [entrez]
AID - S1572-1000(23)00329-0 [pii]
AID - 10.1016/j.pdpdt.2023.103602 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2023 Jun;42:103602. doi: 
      10.1016/j.pdpdt.2023.103602. Epub 2023 May 9.