PMID- 37169479
OWN - NLM
STAT- MEDLINE
DCOM- 20230515
LR  - 20230515
IS  - 1347-8648 (Electronic)
IS  - 1347-8613 (Linking)
VI  - 152
IP  - 2
DP  - 2023 Jun
TI  - Comparison of the effects of two anesthetics, isoflurane and urethane, on bladder 
      function in rats.
PG  - 144-150
LID - S1347-8613(23)00026-9 [pii]
LID - 10.1016/j.jphs.2023.04.005 [doi]
AB  - We compared the effects of two anesthetics, isoflurane and urethane on bladder 
      function in rats. Arterial pressure, cystometry (CMG), and rhythmic bladder 
      contractions (RBCs) under isovolumetric conditions, mechanosensitive single-unit 
      afferent activities (SAAs), bladder compliance and bladder myogenic 
      microcontractions (bladder microcontractions), and bladder blood flow, and blood 
      and urine biochemical tests were investigated in isoflurane- or 
      urethane-anesthetized female rats. In results of the CMG, 3/8 rats in the 
      isoflurane group and 7/7 rats in the urethane group showed constant bladder 
      neurogenic contractions for micturition, whereas 5/8 rats in the isoflurane group 
      showed unstable contractions or overflow incontinence. The RBCs appeared in the 
      urethane group but not in the isoflurane group, and SAAs in both the Adelta- and 
      C-fibers, bladder compliance, and bladder microcontractions in the isoflurane 
      group were higher than those in the urethane group during bladder distension. The 
      blood biochemical test showed that the serum calcium level was higher in the 
      isoflurane group. The mean arterial pressure and bladder blood flow were not 
      different between the groups. The results showed that urethane anesthesia more 
      retains bladder neurogenic contractions for micturition compared to isoflurane. 
      In contrast, isoflurane anesthesia more retains bladder function during the 
      storage phase compared to urethane.
CI  - Copyright (c) 2023 The Authors. Production and hosting by Elsevier B.V. All rights 
      reserved.
FAU - Aizawa, Naoki
AU  - Aizawa N
AD  - Department of Pharmacology and Toxicology, Dokkyo Medical University School of 
      Medicine, Tochigi, Japan. Electronic address: naoki-aizawa@hotmail.co.jp.
FAU - Fujita, Tomoe
AU  - Fujita T
AD  - Department of Pharmacology and Toxicology, Dokkyo Medical University School of 
      Medicine, Tochigi, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230413
PL  - Japan
TA  - J Pharmacol Sci
JT  - Journal of pharmacological sciences
JID - 101167001
RN  - 3IN71E75Z5 (Urethane)
RN  - CYS9AKD70P (Isoflurane)
RN  - 0 (Carbamates)
RN  - 0 (Amides)
RN  - 0 (Anesthetics)
RN  - 0 (Anesthetics, Intravenous)
SB  - IM
MH  - Rats
MH  - Female
MH  - Animals
MH  - Urethane/pharmacology
MH  - Urinary Bladder
MH  - *Isoflurane/pharmacology
MH  - Rats, Sprague-Dawley
MH  - Muscle Contraction
MH  - Carbamates/pharmacology
MH  - *Urinary Bladder, Neurogenic
MH  - Amides/pharmacology
MH  - *Anesthetics/pharmacology
MH  - Urination
MH  - Anesthetics, Intravenous/pharmacology
OTO - NOTNLM
OT  - Afferent
OT  - Isoflurane
OT  - Rats
OT  - Sprague-Dawley
OT  - Urethane
OT  - Urinary bladder
COIS- Declaration of competing interests All authors report no conflict of interest.
EDAT- 2023/05/12 01:07
MHDA- 2023/05/15 06:42
CRDT- 2023/05/11 20:58
PHST- 2023/01/08 00:00 [received]
PHST- 2023/04/03 00:00 [revised]
PHST- 2023/04/11 00:00 [accepted]
PHST- 2023/05/15 06:42 [medline]
PHST- 2023/05/12 01:07 [pubmed]
PHST- 2023/05/11 20:58 [entrez]
AID - S1347-8613(23)00026-9 [pii]
AID - 10.1016/j.jphs.2023.04.005 [doi]
PST - ppublish
SO  - J Pharmacol Sci. 2023 Jun;152(2):144-150. doi: 10.1016/j.jphs.2023.04.005. Epub 
      2023 Apr 13.